ID   QVR_DROPE               Reviewed;         160 AA.
AC   B4GAN3;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Protein quiver {ECO:0000250|UniProtKB:B5A5T4};
DE   AltName: Full=Protein sleepless;
DE   Flags: Precursor;
GN   Name=qvr {ECO:0000250|UniProtKB:B5A5T4}; Synonyms=sss; ORFNames=GL11411;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1] {ECO:0000312|EMBL:EDW31985.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for homeostatic regulation of sleep under normal
CC       conditions and after sleep deprivation. Important regulator of the Sh
CC       K(+) channel, acting as a signaling molecule that connects sleep drive
CC       to lowered membrane excitability, possibly by enhancing K(+) channel
CC       activity and thus reducing neuronal excitability (By similarity).
CC       {ECO:0000250|UniProtKB:B5A5T4}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B5A5T4};
CC       Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:B5A5T4}.
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:B5A5T4}.
CC   -!- SIMILARITY: Belongs to the quiver family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW31985.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH479181; EDW31985.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002016095.1; XM_002016059.1.
DR   AlphaFoldDB; B4GAN3; -.
DR   EnsemblMetazoa; FBtr0177026; FBpp0175518; FBgn0149020.
DR   ChiTaRS; qvr; fly.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0034235; F:GPI anchor binding; ISS:UniProtKB.
DR   GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISS:UniProtKB.
DR   GO; GO:0032222; P:regulation of synaptic transmission, cholinergic; IEA:InterPro.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0030431; P:sleep; IEA:InterPro.
DR   InterPro; IPR031424; QVR.
DR   Pfam; PF17064; QVR; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..128
FT                   /note="Protein quiver"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000365464"
FT   PROPEP          129..160
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250|UniProtKB:B5A5T4"
FT                   /id="PRO_0000365465"
FT   LIPID           128
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:B5A5T4"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  18452 MW;  5BF47E8A9E5459C3 CRC64;
     MWREKGNAIG NWLLAITAIF GFITLIWIPQ ASAECQTRSI YCYECDSWTD ARCKDPFNYT
     ALPRDQPPLM TCNGCCVKMV RHQRSRYEVV RRMCTSQLQI NLFMVDHVCM MESSGNGHMC
     FCEEDMCNSS KDLYSHGHQL HLIITIAVAV SWLMGQLLNR