ID   QVR_DROPS               Reviewed;         159 AA.
AC   B5E022;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Protein quiver {ECO:0000250|UniProtKB:B5A5T4};
DE   AltName: Full=Protein sleepless;
DE   Flags: Precursor;
GN   Name=qvr {ECO:0000250|UniProtKB:B5A5T4}; Synonyms=sss; ORFNames=GA24714;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EDY68906.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for homeostatic regulation of sleep under normal
CC       conditions and after sleep deprivation. Important regulator of the Sh
CC       K(+) channel, acting as a signaling molecule that connects sleep drive
CC       to lowered membrane excitability, possibly by enhancing K(+) channel
CC       activity and thus reducing neuronal excitability (By similarity).
CC       {ECO:0000250|UniProtKB:B5A5T4}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B5A5T4};
CC       Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:B5A5T4}.
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:B5A5T4}.
CC   -!- SIMILARITY: Belongs to the quiver family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDY68906.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000071; EDY68906.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; B5E022; -.
DR   STRING; 46245.B5E022; -.
DR   eggNOG; ENOG502TCD1; Eukaryota.
DR   InParanoid; B5E022; -.
DR   ChiTaRS; qvr; fly.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0034235; F:GPI anchor binding; ISS:UniProtKB.
DR   GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISS:UniProtKB.
DR   GO; GO:0032222; P:regulation of synaptic transmission, cholinergic; IEA:InterPro.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0030431; P:sleep; IEA:InterPro.
DR   InterPro; IPR031424; QVR.
DR   Pfam; PF17064; QVR; 1.
PE   3: Inferred from homology;
KW   Biological rhythms; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..127
FT                   /note="Protein quiver"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000365466"
FT   PROPEP          128..159
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250|UniProtKB:B5A5T4"
FT                   /id="PRO_0000365467"
FT   LIPID           127
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:B5A5T4"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  18261 MW;  7B29118704980C54 CRC64;
     MWKEKGNAIG NWLLAITAIF GFITLIWIPQ ASAECQTRSI YCYECDSWTD ARCKDPFNYT
     ALPRDQPPLM TCNGCCVKMV RHQRSREVVR RMCTSQLQIN LFMVDHVCMM ESSGNGHMCF
     CEEDMCNSSK DLYSHGHQLH LIITIAVAVS WLMGQLLNR