QVR_DROWI
ID QVR_DROWI Reviewed; 161 AA.
AC B4MQJ1;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Protein quiver {ECO:0000250|UniProtKB:B5A5T4};
DE AltName: Full=Protein sleepless;
DE Flags: Precursor;
GN Name=qvr {ECO:0000250|UniProtKB:B5A5T4}; Synonyms=sss; ORFNames=GK19387;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1] {ECO:0000312|EMBL:EDW74380.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW74380.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for homeostatic regulation of sleep under normal
CC conditions and after sleep deprivation. Important regulator of the Sh
CC K(+) channel, acting as a signaling molecule that connects sleep drive
CC to lowered membrane excitability, possibly by enhancing K(+) channel
CC activity and thus reducing neuronal excitability (By similarity).
CC {ECO:0000250|UniProtKB:B5A5T4}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B5A5T4};
CC Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:B5A5T4}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:B5A5T4}.
CC -!- SIMILARITY: Belongs to the quiver family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW74380.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH963849; EDW74380.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; B4MQJ1; -.
DR InParanoid; B4MQJ1; -.
DR ChiTaRS; qvr; fly.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0034235; F:GPI anchor binding; ISS:UniProtKB.
DR GO; GO:1903049; P:negative regulation of acetylcholine-gated cation channel activity; IEA:EnsemblMetazoa.
DR GO; GO:0045837; P:negative regulation of membrane potential; IEA:EnsemblMetazoa.
DR GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
DR GO; GO:1903818; P:positive regulation of voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISS:UniProtKB.
DR GO; GO:0032222; P:regulation of synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0030431; P:sleep; IEA:EnsemblMetazoa.
DR InterPro; IPR031424; QVR.
DR Pfam; PF17064; QVR; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..128
FT /note="Protein quiver"
FT /evidence="ECO:0000255"
FT /id="PRO_0000365474"
FT PROPEP 129..161
FT /note="Removed in mature form"
FT /evidence="ECO:0000250|UniProtKB:B5A5T4"
FT /id="PRO_0000365475"
FT LIPID 128
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000250|UniProtKB:B5A5T4"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 161 AA; 18520 MW; 6C8200146606DFE8 CRC64;
MSLPAGNAVG NWLLILTAIF GFLTLIWIPQ ASAECQTRSI YCYECDSWTD ARCKDPFNYT
ALPRDQPPLM TCNGCCVKMV RHQRSRYEVV RRMCTSQLQI NLFMVDHVCM MESSGNGHMC
FCEEDMCNSS KNLYTKNGYQ HLINIMIIWL IGILLNQLSN R
