R10B1_HUMAN
ID R10B1_HUMAN Reviewed; 870 AA.
AC P0C881; A6NMW7; Q86ST9; Q8NE68;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Radial spoke head 10 homolog B;
GN Name=RSPH10B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-784.
RC TISSUE=Testis;
RA Kerlavage A.R.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 757-870.
RC TISSUE=Cervix adenocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with RSPH6A. {ECO:0000250|UniProtKB:E9PYQ0}.
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DR EMBL; AC005995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AA382672; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AW474289; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS34598.1; -.
DR RefSeq; XP_005249716.1; XM_005249659.3.
DR AlphaFoldDB; P0C881; -.
DR SMR; P0C881; -.
DR BioGRID; 128823; 1.
DR IntAct; P0C881; 2.
DR STRING; 9606.ENSP00000385443; -.
DR iPTMnet; P0C881; -.
DR PhosphoSitePlus; P0C881; -.
DR BioMuta; RSPH10B; -.
DR DMDM; 205829389; -.
DR MassIVE; P0C881; -.
DR PaxDb; P0C881; -.
DR PeptideAtlas; P0C881; -.
DR PRIDE; P0C881; -.
DR ProteomicsDB; 52415; -.
DR Antibodypedia; 57710; 48 antibodies from 13 providers.
DR DNASU; 222967; -.
DR Ensembl; ENST00000337579.4; ENSP00000338556.3; ENSG00000155026.16.
DR Ensembl; ENST00000404406.5; ENSP00000384097.1; ENSG00000155026.16.
DR Ensembl; ENST00000405415.5; ENSP00000385443.1; ENSG00000155026.16.
DR GeneID; 222967; -.
DR MANE-Select; ENST00000404406.6; ENSP00000384097.1; NM_173565.5; NP_775836.4.
DR UCSC; uc003sph.1; human.
DR CTD; 222967; -.
DR GeneCards; RSPH10B; -.
DR HGNC; HGNC:27362; RSPH10B.
DR HPA; ENSG00000155026; Group enriched (fallopian tube, testis).
DR neXtProt; NX_P0C881; -.
DR OpenTargets; ENSG00000155026; -.
DR VEuPathDB; HostDB:ENSG00000155026; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000159899; -.
DR HOGENOM; CLU_012108_1_0_1; -.
DR InParanoid; P0C881; -.
DR OMA; VIVAYHI; -.
DR OrthoDB; 1309439at2759; -.
DR PhylomeDB; P0C881; -.
DR TreeFam; TF328649; -.
DR PathwayCommons; P0C881; -.
DR SignaLink; P0C881; -.
DR BioGRID-ORCS; 222967; 20 hits in 946 CRISPR screens.
DR ChiTaRS; RSPH10B; human.
DR GenomeRNAi; 222967; -.
DR Pharos; P0C881; Tdark.
DR PRO; PR:P0C881; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0C881; protein.
DR Bgee; ENSG00000155026; Expressed in right uterine tube and 90 other tissues.
DR ExpressionAtlas; P0C881; baseline and differential.
DR Genevisible; P0C881; HS.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 10.
DR SMART; SM00698; MORN; 9.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..870
FT /note="Radial spoke head 10 homolog B"
FT /id="PRO_0000311943"
FT REPEAT 86..108
FT /note="MORN 1"
FT REPEAT 109..131
FT /note="MORN 2"
FT REPEAT 132..154
FT /note="MORN 3"
FT REPEAT 155..177
FT /note="MORN 4"
FT REPEAT 179..201
FT /note="MORN 5"
FT REPEAT 204..226
FT /note="MORN 6"
FT REPEAT 227..249
FT /note="MORN 7"
FT REPEAT 251..273
FT /note="MORN 8"
FT REPEAT 284..306
FT /note="MORN 9"
FT REPEAT 307..329
FT /note="MORN 10"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 784..811
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 100635 MW; E397C887499675C0 CRC64;
MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD
RQNVQQNEDA TQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG
QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI
GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG
RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY
YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA
PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL
RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE
IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NAFQIKGNLF
REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF
MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK
HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV
SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNMYVFFV NTLFHAYKRE
EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV
SSSHLILDPP KEDVTVSPSS KTITSKKKKK
