R10B2_HUMAN
ID R10B2_HUMAN Reviewed; 870 AA.
AC B2RC85; A6NMW7; B2RXI4; B2RXJ0; Q86ST9; Q8NE68;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Radial spoke head 10 homolog B2;
GN Name=RSPH10B2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP LYS-836.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with RSPH6A. {ECO:0000250|UniProtKB:E9PYQ0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B2RC85-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B2RC85-2; Sequence=VSP_035277, VSP_035278, VSP_035279;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG37482.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK314983; BAG37482.1; ALT_INIT; mRNA.
DR EMBL; AC073343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034495; AAH34495.2; -; mRNA.
DR EMBL; BC044242; AAH44242.1; -; mRNA.
DR EMBL; BC157864; AAI57865.1; -; mRNA.
DR EMBL; BC157871; AAI57872.1; -; mRNA.
DR CCDS; CCDS43552.1; -. [B2RC85-1]
DR RefSeq; NP_001093167.1; NM_001099697.1. [B2RC85-1]
DR RefSeq; NP_775836.3; NM_173565.3.
DR AlphaFoldDB; B2RC85; -.
DR SMR; B2RC85; -.
DR BioGRID; 128823; 1.
DR BioGRID; 608628; 8.
DR IntAct; B2RC85; 2.
DR STRING; 9606.ENSP00000384766; -.
DR iPTMnet; B2RC85; -.
DR PhosphoSitePlus; B2RC85; -.
DR BioMuta; RSPH10B2; -.
DR MassIVE; B2RC85; -.
DR PaxDb; B2RC85; -.
DR PeptideAtlas; B2RC85; -.
DR PRIDE; B2RC85; -.
DR ProteomicsDB; 3422; -. [B2RC85-1]
DR Antibodypedia; 76939; 3 antibodies from 2 providers.
DR DNASU; 222967; -.
DR DNASU; 728194; -.
DR Ensembl; ENST00000297186.7; ENSP00000297186.3; ENSG00000169402.15. [B2RC85-1]
DR Ensembl; ENST00000403107.5; ENSP00000384766.1; ENSG00000169402.15. [B2RC85-1]
DR Ensembl; ENST00000404077.5; ENSP00000386102.1; ENSG00000169402.15. [B2RC85-1]
DR GeneID; 222967; -.
DR GeneID; 728194; -.
DR KEGG; hsa:222967; -.
DR KEGG; hsa:728194; -.
DR MANE-Select; ENST00000404077.6; ENSP00000386102.1; NM_001099697.2; NP_001093167.1.
DR UCSC; uc003sqw.1; human. [B2RC85-1]
DR CTD; 222967; -.
DR CTD; 728194; -.
DR GeneCards; RSPH10B2; -.
DR HGNC; HGNC:34385; RSPH10B2.
DR HPA; ENSG00000169402; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_B2RC85; -.
DR OpenTargets; ENSG00000155026; -.
DR OpenTargets; ENSG00000169402; -.
DR PharmGKB; PA162402247; -.
DR VEuPathDB; HostDB:ENSG00000169402; -.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000159899; -.
DR HOGENOM; CLU_012108_1_0_1; -.
DR InParanoid; B2RC85; -.
DR OMA; IHPNACH; -.
DR OrthoDB; 1309439at2759; -.
DR PhylomeDB; B2RC85; -.
DR TreeFam; TF328649; -.
DR PathwayCommons; B2RC85; -.
DR SignaLink; B2RC85; -.
DR BioGRID-ORCS; 222967; 20 hits in 946 CRISPR screens.
DR BioGRID-ORCS; 728194; 57 hits in 977 CRISPR screens.
DR ChiTaRS; RSPH10B2; human.
DR GeneWiki; RSPH10B; -.
DR Pharos; B2RC85; Tdark.
DR PRO; PR:B2RC85; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; B2RC85; protein.
DR Bgee; ENSG00000169402; Expressed in right uterine tube and 95 other tissues.
DR ExpressionAtlas; B2RC85; baseline and differential.
DR Genevisible; B2RC85; HS.
DR InterPro; IPR003409; MORN.
DR Pfam; PF02493; MORN; 10.
DR SMART; SM00698; MORN; 9.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..870
FT /note="Radial spoke head 10 homolog B2"
FT /id="PRO_0000349254"
FT REPEAT 86..108
FT /note="MORN 1"
FT REPEAT 109..131
FT /note="MORN 2"
FT REPEAT 132..154
FT /note="MORN 3"
FT REPEAT 155..177
FT /note="MORN 4"
FT REPEAT 179..201
FT /note="MORN 5"
FT REPEAT 204..226
FT /note="MORN 6"
FT REPEAT 227..249
FT /note="MORN 7"
FT REPEAT 251..273
FT /note="MORN 8"
FT REPEAT 284..306
FT /note="MORN 9"
FT REPEAT 307..329
FT /note="MORN 10"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 784..811
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..234
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035277"
FT VAR_SEQ 511..514
FT /note="KRSP -> QFIP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035278"
FT VAR_SEQ 515..870
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035279"
FT VARIANT 836
FT /note="E -> K (in dbSNP:rs17855578)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037357"
FT CONFLICT 148
FT /note="T -> M (in Ref. 3; AAI57865)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="M -> I (in Ref. 3; AAH34495)"
FT /evidence="ECO:0000305"
FT CONFLICT 619
FT /note="F -> L (in Ref. 1; BAG37482)"
FT /evidence="ECO:0000305"
FT CONFLICT 765
FT /note="T -> M (in Ref. 1; BAG37482 and 3; AAH34495/
FT AAI57865/AAI57872)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 870 AA; 100547 MW; 7608F2CC07A70628 CRC64;
MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD
RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG
QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI
GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG
RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY
YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA
PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL
RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE
IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF
REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF
MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK
HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV
SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNTYVFFV NTLFHAYKRE
EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV
SSSHLILDPP KEDVTVSPSS KTITSKKKKK
