R113B_HUMAN
ID R113B_HUMAN Reviewed; 322 AA.
AC Q8IZP6; Q8WWF9; Q96QY9;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=RING finger protein 113B;
DE AltName: Full=Zinc finger protein 183-like 1;
GN Name=RNF113B; Synonyms=RNF161, ZNF183L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Bonner T.I., Ferraren D.O., Detera-Wadleigh S.;
RT "A testis cDNA for a zinc finger gene closely related to ZNF183.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 246-313.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the RING domain of the zinc finger protein 183-like
RT 1.";
RL Submitted (NOV-2005) to the PDB data bank.
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DR EMBL; AF539427; AAN33063.1; -; mRNA.
DR EMBL; AL136300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017585; AAH17585.1; -; mRNA.
DR EMBL; BC025388; AAH25388.1; -; mRNA.
DR CCDS; CCDS9486.1; -.
DR RefSeq; NP_849192.1; NM_178861.4.
DR PDB; 2CSY; NMR; -; A=246-313.
DR PDBsum; 2CSY; -.
DR AlphaFoldDB; Q8IZP6; -.
DR SMR; Q8IZP6; -.
DR BioGRID; 126603; 8.
DR IntAct; Q8IZP6; 4.
DR STRING; 9606.ENSP00000267291; -.
DR iPTMnet; Q8IZP6; -.
DR PhosphoSitePlus; Q8IZP6; -.
DR BioMuta; RNF113B; -.
DR DMDM; 51338806; -.
DR jPOST; Q8IZP6; -.
DR MassIVE; Q8IZP6; -.
DR MaxQB; Q8IZP6; -.
DR PaxDb; Q8IZP6; -.
DR PeptideAtlas; Q8IZP6; -.
DR PRIDE; Q8IZP6; -.
DR ProteomicsDB; 71393; -.
DR Antibodypedia; 10782; 235 antibodies from 24 providers.
DR DNASU; 140432; -.
DR Ensembl; ENST00000267291.7; ENSP00000267291.6; ENSG00000139797.8.
DR GeneID; 140432; -.
DR KEGG; hsa:140432; -.
DR MANE-Select; ENST00000267291.7; ENSP00000267291.6; NM_178861.5; NP_849192.1.
DR UCSC; uc001vnk.4; human.
DR CTD; 140432; -.
DR GeneCards; RNF113B; -.
DR HGNC; HGNC:17267; RNF113B.
DR HPA; ENSG00000139797; Tissue enriched (testis).
DR neXtProt; NX_Q8IZP6; -.
DR OpenTargets; ENSG00000139797; -.
DR PharmGKB; PA38217; -.
DR VEuPathDB; HostDB:ENSG00000139797; -.
DR eggNOG; KOG1813; Eukaryota.
DR GeneTree; ENSGT00390000016292; -.
DR HOGENOM; CLU_050460_1_0_1; -.
DR InParanoid; Q8IZP6; -.
DR OMA; ANFRKKP; -.
DR OrthoDB; 1420266at2759; -.
DR PhylomeDB; Q8IZP6; -.
DR TreeFam; TF313469; -.
DR PathwayCommons; Q8IZP6; -.
DR SignaLink; Q8IZP6; -.
DR BioGRID-ORCS; 140432; 5 hits in 1101 CRISPR screens.
DR EvolutionaryTrace; Q8IZP6; -.
DR GenomeRNAi; 140432; -.
DR Pharos; Q8IZP6; Tdark.
DR PRO; PR:Q8IZP6; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8IZP6; protein.
DR Bgee; ENSG00000139797; Expressed in left testis and 24 other tissues.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034247; P:snoRNA splicing; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR039971; CWC24-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12930; PTHR12930; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..322
FT /note="RING finger protein 113B"
FT /id="PRO_0000056088"
FT ZN_FING 190..218
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 256..294
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 24..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 92
FT /note="V -> M (in dbSNP:rs16955011)"
FT /id="VAR_052104"
FT CONFLICT 56
FT /note="V -> A (in Ref. 1; AAN33063)"
FT /evidence="ECO:0000305"
FT STRAND 257..259
FT /evidence="ECO:0007829|PDB:2CSY"
FT STRAND 265..268
FT /evidence="ECO:0007829|PDB:2CSY"
FT STRAND 274..276
FT /evidence="ECO:0007829|PDB:2CSY"
FT HELIX 277..286
FT /evidence="ECO:0007829|PDB:2CSY"
FT STRAND 291..293
FT /evidence="ECO:0007829|PDB:2CSY"
FT HELIX 305..311
FT /evidence="ECO:0007829|PDB:2CSY"
SQ SEQUENCE 322 AA; 36259 MW; 9D2E63F623150578 CRC64;
MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG DEGDTVAQPP
RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA KPVGPEDMGA TADFEQDTEK
EHHTPTILKC SQRVQEALRG REHDHIYRGI HSYLRYLKPK DTSMGNSSSG MARKGPIRAP
GHLRATVRWD YQPDICKDYK ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED
ENHEVGSEEE EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
FNPAKELMAK LQKLQAAEGK KR
