ID   R13L2_ARATH             Reviewed;         847 AA.
AC   Q9STE5;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Putative disease resistance RPP13-like protein 2;
GN   Name=RPP13L2; OrderedLocusNames=At3g46710; ORFNames=T6H20.260;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Potential disease resistance protein.
CC   -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC       pathogen recognition. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP13
CC       subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC       of disease resistance gene homologs;
CC       URL="http://niblrrs.ucdavis.edu";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL096859; CAB51194.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE78196.1; -; Genomic_DNA.
DR   PIR; T12979; T12979.
DR   RefSeq; NP_190255.1; NM_114538.2.
DR   AlphaFoldDB; Q9STE5; -.
DR   SMR; Q9STE5; -.
DR   BioGRID; 9144; 2.
DR   IntAct; Q9STE5; 1.
DR   STRING; 3702.AT3G46710.1; -.
DR   iPTMnet; Q9STE5; -.
DR   PaxDb; Q9STE5; -.
DR   PRIDE; Q9STE5; -.
DR   EnsemblPlants; AT3G46710.1; AT3G46710.1; AT3G46710.
DR   GeneID; 823824; -.
DR   Gramene; AT3G46710.1; AT3G46710.1; AT3G46710.
DR   KEGG; ath:AT3G46710; -.
DR   Araport; AT3G46710; -.
DR   TAIR; locus:2102857; AT3G46710.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_000837_25_4_1; -.
DR   InParanoid; Q9STE5; -.
DR   OMA; WESEALE; -.
DR   OrthoDB; 463722at2759; -.
DR   PhylomeDB; Q9STE5; -.
DR   PRO; PR:Q9STE5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9STE5; baseline and differential.
DR   Genevisible; Q9STE5; AT.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..847
FT                   /note="Putative disease resistance RPP13-like protein 2"
FT                   /id="PRO_0000212727"
FT   DOMAIN          142..446
FT                   /note="NB-ARC"
FT   REPEAT          587..610
FT                   /note="LRR 1"
FT   REPEAT          612..634
FT                   /note="LRR 2"
FT   REPEAT          703..726
FT                   /note="LRR 3"
FT   REPEAT          749..774
FT                   /note="LRR 4"
FT   REPEAT          807..830
FT                   /note="LRR 5"
FT   COILED          26..42
FT                   /evidence="ECO:0000255"
FT   BINDING         191..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   847 AA;  98479 MW;  03C1F484A3C98696 CRC64;
     MVDAITEFVV GKIDNYLIEE APMLIGVKDD LEELKTELTC IQVYLKNVEV CDKEDEVSKE
     WTKLVLDIAY DVEDVLDTYF LKLEKRLHRL GLMRLTNIIS DKKDAYNILD DIKTLKRRTL
     DVTRKLEMYG IGNFNEHRVV ASTSRVREVR RARSDDQEER VVGLTDDAKV LLTKLLDDDG
     DNKIYMISIF GMEGLGKTSL ARKLFNSSDV KESFEYRVWT NVSGECNTRD ILMRIISSLE
     ETSEGELEKM AQQELEVYLH DILQEKRYLV VVDDIWESEA LESLKRALPC SYQGSRVIIT
     TSIRVVAEGR DKRVYTHNIR FLTFKESWNL FEKKAFRYIL KVDQELQKIG KEMVQKCGGL
     PRTTVVLAGL MSRKKPNEWN DVWSSLRVKD DNIHVSSLFD LSFKDMGHEL KLCFLYLSVF
     PEDYEVDVEK LIQLLVAEGF IQEDEEMTME DVARYYIEDL VYISLVEVVK RKKGKLMSFR
     IHDLVREFTI KKSKELNFVN VYDEQHSSTT SRREVVHHLM DDNYLCDRRV NTQMRSFLFF
     GKRRNDITYV ETITLKLKLL RVLNLGGLHF ICQGYSPWSL PDVIGGLVHL RYLGIADTVV
     NNLPDFISNL RFLQTLDASG NSFERMTDLS NLTSLRHLTG RFIGELLIGD AVNLQTLRSI
     SSYSWSKLKH ELLINLRDLE IYEFHILNDQ IKVPLDLVSL SKLKNLRVLK IEVVSFSLFS
     EETVRFELLV KLTLHCDVRR LPRDMDLIFP SLESLTLVTN LQEDPMPTLQ KLQRLENLVL
     YSCVYPGAKM FINAQGFGRL RKLKVIIKRL DELEIEEEAM PCLMKLNLDN KDGATKLMIP
     DRMRAFV