R13L3_ARATH
ID R13L3_ARATH Reviewed; 847 AA.
AC Q9STE7;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Putative disease resistance RPP13-like protein 3;
GN Name=RPP13L3; OrderedLocusNames=At3g46730; ORFNames=T6H20.240;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Potential disease resistance protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family. RPP13
CC subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AL096859; CAB51192.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78198.1; -; Genomic_DNA.
DR PIR; T12977; T12977.
DR RefSeq; NP_190257.1; NM_114540.2.
DR AlphaFoldDB; Q9STE7; -.
DR SMR; Q9STE7; -.
DR BioGRID; 9146; 1.
DR STRING; 3702.AT3G46730.1; -.
DR PaxDb; Q9STE7; -.
DR PRIDE; Q9STE7; -.
DR ProteomicsDB; 236208; -.
DR EnsemblPlants; AT3G46730.1; AT3G46730.1; AT3G46730.
DR GeneID; 823826; -.
DR Gramene; AT3G46730.1; AT3G46730.1; AT3G46730.
DR KEGG; ath:AT3G46730; -.
DR Araport; AT3G46730; -.
DR TAIR; locus:504956483; AT3G46730.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_4_1; -.
DR InParanoid; Q9STE7; -.
DR OMA; KRRFDCR; -.
DR OrthoDB; 463722at2759; -.
DR PhylomeDB; Q9STE7; -.
DR PRO; PR:Q9STE7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9STE7; baseline and differential.
DR Genevisible; Q9STE7; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Nucleotide-binding; Plant defense;
KW Reference proteome; Repeat.
FT CHAIN 1..847
FT /note="Putative disease resistance RPP13-like protein 3"
FT /id="PRO_0000212728"
FT DOMAIN 143..453
FT /note="NB-ARC"
FT COILED 24..41
FT /evidence="ECO:0000255"
FT BINDING 192..199
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 847 AA; 98142 MW; 3663C129C8E57D93 CRC64;
MVDAVTGFVL NKIGGYLINE VLALMGVKDD LEELKTELTC IHGYLKDVEA REREDEVSKE
WTKLVLDIAY DIEDVLDTYF LKLEERSLRR GLLRLTNKIG KKRDAYNIVE DIRTLKRRIL
DITRKRETFG IGSFNEPRGE NITNVRVRQL RRAPPVDQEE LVVGLEDDVK ILLVKLLSDN
EKDKSYIISI FGMGGLGKTA LARKLYNSGD VKRRFDCRAW TYVSQEYKTR DILIRIIRSL
GIVSAEEMEK IKMFEEDEEL EVYLYGLLEG KNYMVVVDDV WDPDAWESLK RALPCDHRGS
KVIITTRIRA IAEGVEGTVY AHKLRFLTFE ESWTLFERKA FSNIEKVDED LQRTGKEMVK
KCGGLPLAIV VLSGLLSRKR TNEWHEVCAS LWRRLKDNSI HISTVFDLSF KEMRHELKLC
FLYFSVFPED YEIKVEKLIH LLVAEGFIQE DEEMMMEDVA RCYIDELVDR SLVKAERIER
GKVMSCRIHD LLRDLAIKKA KELNFVNVYN EKQHSSDICR REVVHHLMND YYLCDRRVNK
RMRSFLFIGE RRGFGYVNTT NLKLKLLRVL NMEGLLFVSK NISNTLPDVI GELIHLRYLG
IADTYVSILP ASISNLRFLQ TLDASGNDPF QYTTDLSKLT SLRHVIGKFV GECLIGEGVN
LQTLRSISSY SWSKLNHELL RNLQDLEIYD HSKWVDQRRV PLNFVSFSKP KNLRVLKLEM
RNFKLSSESR TTIGLVDVNF PSLESLTLVG TTLEENSMPA LQKLPRLEDL VLKDCNYSGV
KIMSISAQGF GRLKNLEMSM ERRGHGLDEL RIEEEAMPSL IKLTVKGRLE LTKLMIPDRL
KAFVRRN
