ID   R1A3_SOLDE              Reviewed;         775 AA.
AC   Q6L440;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Putative late blight resistance protein homolog R1A-3;
GN   Name=R1A-3; ORFNames=PGEC668E02.10;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype A genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC144791; AAT39942.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L440; -.
DR   SMR; Q6L440; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   5: Uncertain;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response; Membrane;
KW   Nucleotide-binding; Plant defense.
FT   CHAIN           1..775
FT                   /note="Putative late blight resistance protein homolog R1A-
FT                   3"
FT                   /id="PRO_0000233960"
FT   DOMAIN          17..237
FT                   /note="NB-ARC"
FT   DOMAIN          711..775
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   COILED          16..39
FT                   /evidence="ECO:0000255"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   775 AA;  88790 MW;  DC9036EFE1F0E7CB CRC64;
     MKTVIARTSS KLARTPRMNE EIVGFEDVIE NLRKKLLSET KGQDVISIHG MPGLGKTTLA
     NRLYSDRSVV SQFDICAQCC VSQVYSYKDL LLSLLRDAIG DESGSRELPD NELADMLRKT
     LLPRRYLILV DDVWDNSAWD DLRGCFPDVN NRSRIILTTR HHEVAKYASV HSDPLHLRMF
     YEDESWKLLE KKVFGEQSCS PLLKDVGLRI AKLCGKLPLS IVFVAGTLSE MEKEVECWEQ
     MANNLGGPKL SSFLEDRVID ISRLIRLWIS ESFIKSSEGR SLEDIAEGYL ENLIGRNLVM
     VTQRADSDGM VKACRLHDVL LDFCKKRAAE ENFLLCIKRD QSTKAVISHK QQAHLAFSKM
     DNLVEWSASS SLVGSVIFKS YDPYFARCPL SSHAFALSHI LINFKFLKVL DLEHQVVIDF
     NPTEHFYLRY LSAHIDQNSI PSSISNLWNL ETLILKRTPA GRLNTLLLPS TIWDMVKLRH
     LHIPNFRAES EDALLENSAK LYDLETLSTT YFSSVEKAEL MLRKTPNLRK LICEVQFLEY
     PNQYHVLNFP VRLEMLKLYR FNNSKVIPFY ISAPNLKYLK LSGFYLDSHY LSETADHLKH
     LEVLKLYRVE FGDHGEWKVS NGMFPQLKIL KLNYVCLMKW IVADDAFPNL EQLVLRGCKD
     LMEIPFCFMD ILSLKYIELD NCNKSVVKSA KDIEEAQVED NQNTNFKLVI IKKMILQFDI
     SHDKEIDNAF KRLASLPGVD SISIDMIEKK LTVGGDMNAN EVRLVVGKLI DSGML