ID   R1A4_SOLDE              Reviewed;        1244 AA.
AC   Q6L439;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Putative late blight resistance protein homolog R1A-4;
GN   Name=R1A-4; ORFNames=PGEC668E02.11;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype A genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC144791; AAT39943.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L439; -.
DR   SMR; Q6L439; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR021929; Late_blight_resistance_R1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   5: Uncertain;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT   CHAIN           1..1244
FT                   /note="Putative late blight resistance protein homolog R1A-
FT                   4"
FT                   /id="PRO_0000233961"
FT   DOMAIN          527..755
FT                   /note="NB-ARC"
FT   REPEAT          978..1004
FT                   /note="LRR 1"
FT   REPEAT          1079..1103
FT                   /note="LRR 2"
FT   REPEAT          1127..1150
FT                   /note="LRR 3"
FT   REPEAT          1153..1178
FT                   /note="LRR 4"
FT   REPEAT          1213..1237
FT                   /note="LRR 5"
FT   COILED          411..434
FT                   /evidence="ECO:0000255"
FT   COILED          526..548
FT                   /evidence="ECO:0000255"
FT   BINDING         560..567
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1244 AA;  143909 MW;  17EC5AF911ABE974 CRC64;
     MYFNNELSDQ KVCLLRELKN LKYSDDARDR INFFLWELKF LDCFLHLKSF PFASECGMLH
     VSQKMIDIWK SHCSKTINGT ILYYGKVPLN LFVNWKKVIW KTKQEFRAQY SFPKTPLAAN
     KVIDDDDNTH SPKFVMEVID VFVENLNVLM KINDPCSWFF VPGHMKEQIE QVLKELKLLR
     FFVCFVSNKC SIQPQYRCTT FYTHALIEAS HIAMVVWLHL PIYGNVNQDL APSEVSRLFS
     DFMEMKIKSI QPVISRNNIY IDVLQALKST IPQAQKKHAA ESSTVEIPTH SLTVGLSDQM
     ANLQEMLCLL RDNLIHLPIL DLEFHLQDMD SVIIDAGLLI YSLYDIKREK EDTVLDDMNR
     ALGLDLPRNI EPIKVMVYLV MQKAIQCNLP KVHGLGYVDF LLKNLKDFQG RYSDSLAFLK
     NQLQVIQTEF ESLQPFLKVV VEEPQNKLKT LNEDCAIQII RKAHEVEYVV DACINKGIPH
     WCLERWLQDI IEEITCIKAK IQEKNTVDDT MKTVIARTSS KLARTPRMNE EIVGFKDVIE
     NLRNQLLNGT KGQDVISIHG MPGLGKTTLA NRLYSDRSVV SHFDICAQCC VSQVYSYKDL
     LLALLCDAIG EGSVRRELHA NELADMLRKT LLPRRYLILV DDVWENSVWD DLRGCFPDAN
     NRSRIILTTR HHEVAKYASV HSDPLHLRMF DEDESWKLLE KKVFGEQSCS PLLKKVGLRI
     AKMCGQLPLS IVLVAGILSE MEKEVECWEQ VANDLGTHIR SNSRAIVDQS YHVLPCHLKS
     CFLYFGAFLG VREIRISRLI RLWISESFIK SCEGRRLEDI AEGYLENLIG RNLVMVTQRA
     NSNGKVKACR LHDVLLNFCK ERAAEENLLL WINRDQSTKA VYSHKQHAHL AFTKMDNLVE
     WSASSSLVGS VLIMRYNPYF ARCPLYAVSH ILLNFKFLKV LDLKHQVVID FIPTELPYLR
     YLTADIGQNS IPSSISNLWN LETLILNRRS VVHKILLPST VWDMVKLRFL FIPNFSPENK
     KALLKNSPNL DDLETLSYPY FARVKDAELM LRKTPNLRKL TCKVKCLEYL HQYHALNFPI
     RLEILKLYRS NAFKAIPFCI SAPNLKYLKL SGFYLDSQYL SKTADHLKNL EVLKLYYVEF
     GDHREWKVSN GMFPQLKILK LEDVSLMKWI VADDAFPNLE QLVLRGCQDL MEIPSCFMDI
     LSLQYIEVED CNESVVKSAM NIQETQVEDY QNTNFKLVLI EVHY