R1A6_SOLDE
ID R1A6_SOLDE Reviewed; 1306 AA.
AC Q6L438;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Putative late blight resistance protein homolog R1A-6;
GN Name=R1A-6; ORFNames=PGEC668E02.12;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype A genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AC144791; AAT39944.2; -; Genomic_DNA.
DR AlphaFoldDB; Q6L438; -.
DR SMR; Q6L438; -.
DR PRIDE; Q6L438; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1306
FT /note="Putative late blight resistance protein homolog R1A-
FT 6"
FT /id="PRO_0000233962"
FT DOMAIN 521..808
FT /note="NB-ARC"
FT REPEAT 858..881
FT /note="LRR 1"
FT REPEAT 921..935
FT /note="LRR 2"
FT REPEAT 936..961
FT /note="LRR 3"
FT REPEAT 979..1007
FT /note="LRR 4"
FT REPEAT 1010..1035
FT /note="LRR 5"
FT REPEAT 1057..1081
FT /note="LRR 6"
FT REPEAT 1082..1106
FT /note="LRR 7"
FT REPEAT 1110..1129
FT /note="LRR 8"
FT REPEAT 1130..1153
FT /note="LRR 9"
FT REPEAT 1156..1181
FT /note="LRR 10"
FT REPEAT 1216..1240
FT /note="LRR 11"
FT DOMAIN 1240..1306
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT COILED 407..428
FT /evidence="ECO:0000255"
FT COILED 520..542
FT /evidence="ECO:0000255"
FT BINDING 554..561
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1306 AA; 151161 MW; 3ED7B58BE93EE3F8 CRC64;
MYFNNELSDL KDHLLRKLQY YTYSDVVRDR INFILWEFKF LDCFLYLKSF PFASECGMLH
VSQKMIEIWK SQWNKLIYIC MYDEEGSPWD AVVYWKELIS QTKQEFRAQY SFPKSPLAAN
EVIDDDDDDN THSPEFVMEV IGFFVGNINV LVKINDPCSC FFVPGLKEQI EQILKELKLL
RFLVCFVSNK CIVPQYRCTT FYTRALIEAS YIAMVAWLYL PIYGNGNQDL APSEVSRLLS
DFMEMKIKSI EPGISRNSIY IDVLQALKST IPQAQKKHVE IPTHSLTVGL SDQMANLQEM
LCLLRDNLIH LPILDLEFHL QDMDSVIVDA GLLIYSLYDI KGQMEDTSLD VINWALGFDL
PRNIEPIKVM AYLVMQKAFH CNLPRIHGLG YVDFLLKNLN DFQDCYSDSL AFLKNQLQVI
QTEFESLQPF LKVVAEEPHN KLKTLNEDCA TQIIRKAYEV EYVVDACINK EALHWCLERW
LLDIIEEITC IKAKIQEKNT VEDTMKTVIA RTSSKLARTP RMKEEIVGFE DVIENLRKKL
LSRTKGQDVI SIHGMPGLGK TTLANRLYSD RSVVSQFDFC AQCCVSQVYS CKDLLLSLLR
DAIGEESERR ELPDNELADM LRKTLLPRRY LILVDDVWDN SAWDDLRGCF PDVNNRSRII
LTTRHHEVAK YASVRSDPLH LRMFDEVESW KLLEKKVFGE QSCPPLLKNI GLRIAKMCGQ
LPLSIVLVAG ILSEMEKDVE CWEQVANNLG SHIHNDSRAI VDQSYHVLPC HLKSCFLYFG
AFLEDRVIDI SRLIRLWISE AFIKSSEGRS LEDIAEGYLE NLIGRNLVMV TQRAISDGKV
KACRLHDVLL DFCKERAAEE NFLLWINRDQ ITKPSSCVYS HKQHAHLAFT EMHNLVEWSA
SCSFVGSVVL SNKYEPYFHD LSSLHDFSIS RILPNFKFLK VLDLEHRVFI DFIPTELPYL
RYFSALIDQN SIPSSISNLW NLETLILNRR SADSHNRVLL PSTVWDMVKL RHLHIPNFSP
ENKKALLKNS PNLDDLETLS YPYFARVKDA ELMLRKTPNL RKLTCKVKCL EYLHQYHALN
FPIRLEILKL YRSNAFKAIP FCISAPNLKY LKLSGFYLDS QYLSKTADHL KNLEVLKLYY
VEFGDHREWK VSNGMFPQLK ILKLEDVSLM KWIVADDAFP NLEQLVLRGC QDLMEIPSCF
MDILSLQYIE VEDCNESVVK SAMNIQETQV EDYQNTNFKL VLIEKWPKFY KLFSQLSLPR
GLVLHLGIES VSSDEKEKKL TVTGDVDADE VQLVVEKLRK CGMPGL
