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R1A6_SOLDE
ID   R1A6_SOLDE              Reviewed;        1306 AA.
AC   Q6L438;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Putative late blight resistance protein homolog R1A-6;
GN   Name=R1A-6; ORFNames=PGEC668E02.12;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype A genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
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DR   EMBL; AC144791; AAT39944.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L438; -.
DR   SMR; Q6L438; -.
DR   PRIDE; Q6L438; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR021929; Late_blight_resistance_R1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT   CHAIN           1..1306
FT                   /note="Putative late blight resistance protein homolog R1A-
FT                   6"
FT                   /id="PRO_0000233962"
FT   DOMAIN          521..808
FT                   /note="NB-ARC"
FT   REPEAT          858..881
FT                   /note="LRR 1"
FT   REPEAT          921..935
FT                   /note="LRR 2"
FT   REPEAT          936..961
FT                   /note="LRR 3"
FT   REPEAT          979..1007
FT                   /note="LRR 4"
FT   REPEAT          1010..1035
FT                   /note="LRR 5"
FT   REPEAT          1057..1081
FT                   /note="LRR 6"
FT   REPEAT          1082..1106
FT                   /note="LRR 7"
FT   REPEAT          1110..1129
FT                   /note="LRR 8"
FT   REPEAT          1130..1153
FT                   /note="LRR 9"
FT   REPEAT          1156..1181
FT                   /note="LRR 10"
FT   REPEAT          1216..1240
FT                   /note="LRR 11"
FT   DOMAIN          1240..1306
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   COILED          407..428
FT                   /evidence="ECO:0000255"
FT   COILED          520..542
FT                   /evidence="ECO:0000255"
FT   BINDING         554..561
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1306 AA;  151161 MW;  3ED7B58BE93EE3F8 CRC64;
     MYFNNELSDL KDHLLRKLQY YTYSDVVRDR INFILWEFKF LDCFLYLKSF PFASECGMLH
     VSQKMIEIWK SQWNKLIYIC MYDEEGSPWD AVVYWKELIS QTKQEFRAQY SFPKSPLAAN
     EVIDDDDDDN THSPEFVMEV IGFFVGNINV LVKINDPCSC FFVPGLKEQI EQILKELKLL
     RFLVCFVSNK CIVPQYRCTT FYTRALIEAS YIAMVAWLYL PIYGNGNQDL APSEVSRLLS
     DFMEMKIKSI EPGISRNSIY IDVLQALKST IPQAQKKHVE IPTHSLTVGL SDQMANLQEM
     LCLLRDNLIH LPILDLEFHL QDMDSVIVDA GLLIYSLYDI KGQMEDTSLD VINWALGFDL
     PRNIEPIKVM AYLVMQKAFH CNLPRIHGLG YVDFLLKNLN DFQDCYSDSL AFLKNQLQVI
     QTEFESLQPF LKVVAEEPHN KLKTLNEDCA TQIIRKAYEV EYVVDACINK EALHWCLERW
     LLDIIEEITC IKAKIQEKNT VEDTMKTVIA RTSSKLARTP RMKEEIVGFE DVIENLRKKL
     LSRTKGQDVI SIHGMPGLGK TTLANRLYSD RSVVSQFDFC AQCCVSQVYS CKDLLLSLLR
     DAIGEESERR ELPDNELADM LRKTLLPRRY LILVDDVWDN SAWDDLRGCF PDVNNRSRII
     LTTRHHEVAK YASVRSDPLH LRMFDEVESW KLLEKKVFGE QSCPPLLKNI GLRIAKMCGQ
     LPLSIVLVAG ILSEMEKDVE CWEQVANNLG SHIHNDSRAI VDQSYHVLPC HLKSCFLYFG
     AFLEDRVIDI SRLIRLWISE AFIKSSEGRS LEDIAEGYLE NLIGRNLVMV TQRAISDGKV
     KACRLHDVLL DFCKERAAEE NFLLWINRDQ ITKPSSCVYS HKQHAHLAFT EMHNLVEWSA
     SCSFVGSVVL SNKYEPYFHD LSSLHDFSIS RILPNFKFLK VLDLEHRVFI DFIPTELPYL
     RYFSALIDQN SIPSSISNLW NLETLILNRR SADSHNRVLL PSTVWDMVKL RHLHIPNFSP
     ENKKALLKNS PNLDDLETLS YPYFARVKDA ELMLRKTPNL RKLTCKVKCL EYLHQYHALN
     FPIRLEILKL YRSNAFKAIP FCISAPNLKY LKLSGFYLDS QYLSKTADHL KNLEVLKLYY
     VEFGDHREWK VSNGMFPQLK ILKLEDVSLM KWIVADDAFP NLEQLVLRGC QDLMEIPSCF
     MDILSLQYIE VEDCNESVVK SAMNIQETQV EDYQNTNFKL VLIEKWPKFY KLFSQLSLPR
     GLVLHLGIES VSSDEKEKKL TVTGDVDADE VQLVVEKLRK CGMPGL
 
 
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