R1A_SOLDE
ID R1A_SOLDE Reviewed; 1293 AA.
AC Q8W1E0; Q60CZ9;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Late blight resistance protein R1-A;
DE Short=Protein R1;
GN Name=R1A; ORFNames=PGEC472P22.10;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=12000683; DOI=10.1046/j.1365-313x.2001.01292.x;
RA Ballvora A., Ercolano M.R., Weiss J., Meksem K., Bormann C.A.,
RA Oberhagemann P., Salamini F., Gebhardt C.;
RT "The R1 gene for potato resistance to late blight (Phytophthora infestans)
RT belongs to the leucine zipper/NBS/LRR class of plant resistance genes.";
RL Plant J. 30:361-371(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype A genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAU93588.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF447489; AAL39063.1; -; Genomic_DNA.
DR EMBL; AC151815; AAU93588.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q8W1E0; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1293
FT /note="Late blight resistance protein R1-A"
FT /id="PRO_0000233959"
FT DOMAIN 539..826
FT /note="NB-ARC"
FT REPEAT 876..899
FT /note="LRR 1"
FT REPEAT 956..981
FT /note="LRR 2"
FT REPEAT 1027..1049
FT /note="LRR 3"
FT REPEAT 1056..1079
FT /note="LRR 4"
FT REPEAT 1102..1125
FT /note="LRR 5"
FT REPEAT 1149..1172
FT /note="LRR 6"
FT REPEAT 1175..1197
FT /note="LRR 7"
FT REPEAT 1198..1222
FT /note="LRR 8"
FT REPEAT 1235..1259
FT /note="LRR 9"
FT COILED 423..446
FT /evidence="ECO:0000255"
FT COILED 538..560
FT /evidence="ECO:0000255"
FT BINDING 572..579
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1293 AA; 149363 MW; 343D90A411FF3BE9 CRC64;
MNFNNELSDL KNRFLFRTLR AQKCSDVARD RIDFFIWELK FLNCFLHLQS FAFASECGML
DISQKMIEIC KRFNTPPPHN SFAYWKEVIC KRLCAISIQP DASSDDGFAC WKKVIWKTKQ
EFRAKYSFPK TLLADNKVYD DDDTNPKFVM EFIDAVVGNL NVLVKINDPS SLLFVPGPKE
QIEQVLKELK LLRFFVCFVS NKCIEPQYQH TTFYTHALIE ASHIAMVVWL NLPIYGNRNQ
DLASSEVSCL LSDFMEMKIK SIQPDISRNN IYIDVLRALK STIPQAQDKH AAESGIVETP
THNLMVGLSD QMANLQEMLC LLRDNLIHLP ILDLEFHLQD MDSVIVDAGL LIYSLYDIKG
QKEDTTLEDI NQALGFDLPR NIEPIKAMIN LVMQKAFQCN LPRIHGLGYV DFLLKNLKDF
QGRYSDSLDF LKNQLQVIQT EFESLQPFLK VVVEEPHNKL KTLNEDCATQ IIRKAYEVEY
VVDACINKEV PQWCIERWLL DIIEEITCIK AKIQEKNTVE DTMKTVIART SSKLARTPRM
NEEIVGFEDV IENLRKKLLN GTKGQDVISI HGMPGLGKTT LANSLYSDRS VFSQFDICAQ
CCVSQVYSYK DLILALLRDA IGEGSVRREL HANELADMLR KTLLPRRYLI LVDDVWENSV
WDDLRGCFPD VNNRSRIILT TRHHEVAKYA SVHSDPLHLR MFDEVESWKL LEKKVFGEES
CSPLLKNVGL RIAKMCGQLP LSIVLVAGIL SEMEKEVECW EQVANNLGSY IHNDSRAIVD
KSYHVLPCHL KSCFLYFGAF LEDRVIDISR LIRLWISEAF IKSSEGRRLE DIAEGYLENL
IGRNLVMVTQ RSISDGKAKE CRLHDVLLDF CKERAAEENF LLWINRDQIT KPSSCVYSHK
QHAHLAFTEM HNLVEWSASC SFVGSVVLSN KYDSYFSTRD ISSLHDFSIS RILPNFKFLK
VLDLEHRVFI DFIPTELVYL KYFSAHIEQN SIPSSISNLW NLETLILKSP IYALRCTLLL
PSTVWDMVKL RHLYIPDFST RIEAALLENS AKLYNLETLS TLYFSRVEDA ELMLRKTPNL
RKLICEVECL EYPPQYHVLN FPIRLEILKL YRSKFKTIPF CISAPNLKYL KLCGFSLDSQ
YLSETADHLK HLEVLILYKV EFGDHREWKV SNGKFPQLKI LKLEYLSLVK WIVADDAFPN
LEQLVLRGCQ DLMEIPSCFM DILSLKYIGV EYCNESVVKS ALNIQETQVE DYQNTNFKLV
LIEFSLQKKA WKLNLTDAED MHNAVKNILA EIR
