R1B11_SOLDE
ID R1B11_SOLDE Reviewed; 1252 AA.
AC Q6L3Y2; Q6L3Z6;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Putative late blight resistance protein homolog R1B-11;
GN Name=R1B-11; ORFNames=PGEC747E24.1, PGEC872C13.1;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT38780.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC149267; AAT38806.1; -; Genomic_DNA.
DR EMBL; AC149266; AAT38780.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q6L3Y2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 5: Uncertain;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1252
FT /note="Putative late blight resistance protein homolog R1B-
FT 11"
FT /id="PRO_0000233965"
FT DOMAIN 684..736
FT /note="NB-ARC 1"
FT DOMAIN 786..830
FT /note="NB-ARC 2"
FT REPEAT 955..980
FT /note="LRR 1"
FT REPEAT 998..1026
FT /note="LRR 2"
FT REPEAT 1077..1100
FT /note="LRR 3"
FT REPEAT 1103..1125
FT /note="LRR 4"
FT REPEAT 1126..1149
FT /note="LRR 5"
FT REPEAT 1187..1212
FT /note="LRR 6"
FT DOMAIN 1188..1252
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REPEAT 1213..1236
FT /note="LRR 7"
FT COILED 543..566
FT /evidence="ECO:0000255"
SQ SEQUENCE 1252 AA; 144135 MW; FAE144AF7EE7B638 CRC64;
MIEIWKSQCT RILSISPDSG IQYWKKTESM KSQYLEEVGV ALDSFVYWKE VIWKTKQEFR
AEYSFPKTSL AANKVIDDDD INIDSLKFVK EVINVFVGNI NVLVKINDPR SWFFVPGLKE
QIEQVLKEFK LLRFFVCFVS NKCIEPQYRC STFYSHVLIE ASHIAMVVCL HLPIYGNGNQ
DLAPSEKMID IWKSHCPDSF PYMKVISKTN VIIKTLYVDE LRSCPSCNSY DSFDNWKEVI
WKTKQEFRAE YSFPKTSLAV NKVDDVNTHS PKFVMEVIDV FVGNLNVLVE INDPSSWLFV
PGHMKEQIEQ VLKELKLLRF FVCFVSSKCI EPQYRCTTFY TLVLIEASHN AMVVWLHLPV
YGNGNQDLAP SEVSRLFSDF MEMKIKSIEP GISRNSIYID VLQALKSTIP QAQKKQLDIP
THSLTVGFSG QMANLQEMLC LLRDNLIHLP ILDLEFHLQD MDSVIVDAGL LIYSLYDIKG
EKEDTVLDDM NQALGFDLPR NIEPIKAMVY LVMQKAFHCN LPRIHGLGYV DFLLKNLNDF
QGRYSDSLAF LKNQLQVIQT EFESLQPFLK VVAEEPHNKL KTLNEDCATQ IIRKAYEVEY
VVDACINKET PHWCLKCWLL DIIEENTCIK AKIQEKNTVE DTMKSVIART SSQLARTPRM
NEEIVGFEDD LLLALLRDAI GEGSVRRELH ANELSDMLRK TLLPRRYLIL VDDVWENSVW
DDLRGCFPDA NNRSRIFGPS HPMLGPPKSK LPTHQMLSTG REVGEQVANN LGTHIHNDSR
AIVDQSYHVL PCHLKSCFLY FGAFLEDRVI DISRLIRLWI SEAFIKSSEG RSLEDIAEGY
LENLIGRNLV MVTQRAISDG KVKACRLHDV LLDFCKERAA EENFLLWIKR DQTTKAVYSH
KQHAHLAFTE MDNLVEWSAS CSLVGSVLFK SYDPYFACRP LSSHAFAVSH ILLNFKFLKV
LDLEHQIVID FIPTELPYLR YFSALIDQNS IPSSKSNLWN LETLILKRRS AATYKTLLLP
STVWDMVKLI YLYIPNFSPE NKKALFKNSP KLDDLETLSN PYFARVEDYL SETVDHLKHL
EVLELYRVEF GDHGEWKVSS GKFPKLKILK LDYVSLMKWI VADDAFPNLE QLVSLGCQNL
MEIPSCFTDI LSLKYIEVDI CNKSVVKSAK YIQETQVEYN QNTNFKLVII KKLVLKFDRF
HGDEEIRKRL SSLPGIKSIS INRGEKKLTV GGDVDADEVR LVVGKLNKRD ML
