R1B12_SOLDE
ID R1B12_SOLDE Reviewed; 1348 AA.
AC Q6L3Z4;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Putative late blight resistance protein homolog R1B-12;
GN Name=R1B-12; ORFNames=PGEC872C13.3;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC149266; AAT38782.2; -; Genomic_DNA.
DR AlphaFoldDB; Q6L3Z4; -.
DR SMR; Q6L3Z4; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1348
FT /note="Putative late blight resistance protein homolog R1B-
FT 12"
FT /id="PRO_0000233966"
FT DOMAIN 552..848
FT /note="NB-ARC"
FT REPEAT 977..1001
FT /note="LRR 1"
FT REPEAT 1051..1074
FT /note="LRR 2"
FT REPEAT 1123..1147
FT /note="LRR 3"
FT REPEAT 1151..1170
FT /note="LRR 4"
FT REPEAT 1171..1194
FT /note="LRR 5"
FT REPEAT 1197..1219
FT /note="LRR 6"
FT REPEAT 1220..1244
FT /note="LRR 7"
FT DOMAIN 1284..1348
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REPEAT 1309..1332
FT /note="LRR 8"
FT COILED 446..469
FT /evidence="ECO:0000255"
FT COILED 561..583
FT /evidence="ECO:0000255"
FT BINDING 595..602
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1348 AA; 154887 MW; 374EFB2A06D22C3A CRC64;
MAQHGDGKQY MELDQSKGTE MRNKALMDNN MLLETFIQMS EKGRLSSNYM TVTAIVRDVE
QESFAFASEC GILDVSQKML KNFKSLCAIL RSIRPDASSN NAFAYWKEVI CKWLCATLLS
TRPDAGSDDG FAYWKEVIWK TKQEFRAKYP FPETPFAANK VDDVNTHSPK FVMEFIDAVV
GNLNVLVKIN DPSSLLFVPG PNEQTEQVLK ELKLLRFFVC FVSNKCIEPQ YRRTTFYTHA
LIEASHITMV VWLHFPIYGN GNQDLNPGDV SRLLSDFMEM KIKSIQLGIS RNNIYIDVLK
ALKSTIPQAQ NKHAAESGIE ETPTHNLMVG LSDQMANLRE MICLLRDNLI HLPILDLEFH
VQDMDSVIVD AGLLFYSLYD IKGEKEDKTL EDINQALGFD IPRNIEPIKA MVYLVMQKAF
QSNLPRIHGL GYVDFLLKNL KDFQGRYSDS LAFLKNQLQV IQTEFESLQP FLKVVVEEPH
NRLKTLNEDC ATQIIRKAYE VEYVVDACIN KEVPQWCIER WLLDIIEEIT CIKANIQEKN
TVEDTMKTVI GRTSSQLTRT PRMNEEIVGF EDVIENLRKK LLNGTKGQDV ISIHGMPGLG
KTTLANRLYS DRSVVSQFDI CAQCCVSQVY SYKELLLALL CDAVGEDSAR RELPDNELAD
MFRKTLLPRR YLILVDDVWE NSAWDDLRGC FPDVNNRSRI ILTTRHHEVA KYASVHSDPL
HLRMFGEDES WKLLEKKVFG EERCSPLLKN VGLRIAKMCG RLPLSIVLVA GILSEMEKEV
ECWEQVANNL GSHIHNDSRA IVDQSYHVLP FHLKSCFLYF GAFLEDRVIN VSRLIRLWIS
ESFIKSCEGR RLEDIAEGYL ENLIGRNLVM VTQRANSDGK VKACRLHDVL LDFCKERAAE
ENFLLRIKWD QSTKPSSCVY SHKQHAHLAF TGMDNLLEWS TSGSLVGSVL FKNYDPNFAY
NSCSSHAFAI SRILPNFKFL KVLDLEHQFF IDFIPTELLY LRYLSARIGQ NSIPSSISNL
WNLETLILKD VRYMRRCRLL QPNTVWDMVK LRHLHIPYFS TEKEEALLEN SAKLYDLETL
STPYFFRVEN AELMLRKTPN LRKLICAIEC LEYPPQYHVL NFPITLEILK LYRSSDFKVI
PFCISAQNLK YLKLSGFYLN SQYLSETADH LKHLEVLKLH NIEFGGHSEW EVSNAKFPQL
KILKLEYVSL MKLIVADDAF PNLEQLVLHD CEDLMEIPSC FMDILSLKYI EVDNCSESVV
KSARNIQETQ VEDSQNNNFK LVIVKKMVLK FDTSNEKEIS KAFDRLLSLP GIQSIAVDSN
EKKFIVIGDM DADEVRLVVG KLINRGML
