ID   R1B13_SOLDE             Reviewed;        1141 AA.
AC   Q6L3Z0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Putative late blight resistance protein homolog R1B-13;
GN   Name=R1B-13; ORFNames=PGEC872C13.7;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
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DR   EMBL; AC149266; AAT38785.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L3Z0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR021929; Late_blight_resistance_R1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   PANTHER; PTHR23155; PTHR23155; 2.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT   CHAIN           1..1141
FT                   /note="Putative late blight resistance protein homolog R1B-
FT                   13"
FT                   /id="PRO_0000233967"
FT   DOMAIN          516..742
FT                   /note="NB-ARC"
FT   REPEAT          826..851
FT                   /note="LRR 1"
FT   REPEAT          869..894
FT                   /note="LRR 2"
FT   REPEAT          992..1016
FT                   /note="LRR 3"
FT   REPEAT          1017..1041
FT                   /note="LRR 4"
FT   REPEAT          1043..1068
FT                   /note="LRR 5"
FT   COILED          417..437
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1141 AA;  132370 MW;  47066EAA59873D80 CRC64;
     MTKRVITDRL RSTLQDSNYS DVGRDLINFI LWELKFLDCF LHLKSLPFAS ECCMLDVSQK
     MIEILKSRIL SICPDSGIQL WKGNLSMKTL YLEDVRVTLD SFGYWKEVIW KTKQEFSAEY
     SFPNTSLAAN KVDDVSPKFV MEVIDVFVEN LNVVVKINDP ISWLFVPEHK EQIEQVLKEL
     KLLRFFVWFV SNKYIEPQYQ HTTFYIHALI EASHISMAVW LHLPVCSKGN QNLAPSEVSR
     LLSDFVEMKI KATEPGISRN NIYIDVLQDL KLTIPQAQKK HAAESGIVEI LTHSMMVGLS
     DQMANLQEML CLLRDNLIHL PILDLEFHLQ DMDSIIVDAG LLIYSLYDIK GEKEDTTLED
     INRELGFDLP RNIEPIKVIV YLVMQKAFQC NLPRIHGLGY VDFLLKNLKD FQGRYSDSLA
     FLKNQIQVIQ MEFEILQPFL KVVVEEPHNK FKRLNEDCAI QIIRKAHEVE YVVDACINKG
     IPHWCLERWL QDIIEETTCI KAKIQEKNTV EDTMKTVITH TSSQLARTPR MNEEIVWFKD
     VIENLRNRLL NGTKGQDVIS IHSMPGLGKT TLANRLYSDR SIVSQFDICA QCCVSQVYSY
     KELLLALLCD AIGEGSDQHR EIHANELADM LRKTLLPRRY LILVDDVWEN SAWDDLRGCF
     PDVNNRSRII LTTRHHEVAK YASVHSEPLH LRMFEEDESW KLLEKRVFGE ESCSPLLKDV
     GLRIAKMCRQ LPLSIVLVAD VLLDFCKERA AEENFLLWIK RDQITKAAYS HKQHTHLALT
     EMDTLLEWST SGSLVGSVLF KNYDPYFVRS LLSSHAFEIS HILPHFKFLK VLDLEHQVVI
     DFIPTELPYL RYFSALIHQN SIPSSISNLW NLETLILKGT SAKTLLLPST VWDMVKLGYL
     YIPNFSPENK KALLENSPKL DDLETLSNPY FARVEDAELM LRKTPNLRKL ICEVECLEYP
     HQYHVLNFPV QLEILKFYRS KASKTIPFCI SAPNLKYLKL SGYYLDSQYL SETVDHLKHL
     EVLKLYNVEF GDYREWEVSN GKFPQLKILK LENLSLMKWI VADDAFPILE QLVLHDCRDL
     MEIPSCFMDI LSLKYIEVDM SNKSVVKSAK NIEETQVEDN QNTNFKLVII KVHYWEKLYS
     A