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R1B14_SOLDE
ID   R1B14_SOLDE             Reviewed;        1317 AA.
AC   Q6L3Z7;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Putative late blight resistance protein homolog R1B-14;
GN   Name=R1B-14; ORFNames=PGEC858M02.15;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
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DR   EMBL; AC149265; AAT38776.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L3Z7; -.
DR   SMR; Q6L3Z7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR021929; Late_blight_resistance_R1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT   CHAIN           1..1317
FT                   /note="Putative late blight resistance protein homolog R1B-
FT                   14"
FT                   /id="PRO_0000233968"
FT   DOMAIN          521..823
FT                   /note="NB-ARC"
FT   REPEAT          944..968
FT                   /note="LRR 1"
FT   REPEAT          987..1015
FT                   /note="LRR 2"
FT   REPEAT          1090..1114
FT                   /note="LRR 3"
FT   REPEAT          1138..1161
FT                   /note="LRR 4"
FT   REPEAT          1164..1186
FT                   /note="LRR 5"
FT   REPEAT          1187..1211
FT                   /note="LRR 6"
FT   DOMAIN          1251..1317
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   COILED          419..442
FT                   /evidence="ECO:0000255"
FT   COILED          535..556
FT                   /evidence="ECO:0000255"
FT   BINDING         568..575
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1317 AA;  151458 MW;  5928CAB34CC33005 CRC64;
     MYFNNELSGL KDRFLKSLLA QKYPDRINFF LWELKFLDCF LHLQNFAFAS ECGMLDVSQK
     MLKNFKRMCA TFRSIRPNAG SDNAFAYLKE VICKRLCATL LNTRPDACSD DGFAYWNEVI
     WKTKQEFRAK YSFPKTPLAS NKVDDDDINI HSPKFVMEFI DAVVGNLNVL VKINDPCSLL
     FVPGPKEQID QVSKELKLLR FFVCFVSNKC IEPQYGHTTF YIHALIEASH IAMVVWLHLP
     VYGNGNQDLA PSEVSRLLSD FISRNSNYID VLKALKSTIP QAQNKHAAES GIVETPTHNL
     MVGLSDQMVN LQEMLCLLRD NLIHLPILDL EFHLQDMDSV ILDAGLLIYS LYDIEGEKED
     TVLDDMNRAL GFDLPRNIEP IKVMVYLVMQ KAFQCNLPRV HGLGYVDFLL KNLNDFQGRY
     SDSLAFLKNQ LQVIQTEFES LQPFLKVVIE EPHNKLKTLN EDCATQIIRK AYEVEYVVDA
     CINKVAPHWC LERWLLDIIE EITCIKAKIQ EKNTVEDTMK TVITHTSSQL ARTPRMNEEI
     VGFKDVIENL RNRLLNGTKG QDVISIHGMP GLGKTTLANR LYSDRSVVSH FDICAQCCVS
     QVYSYKELLL ALLCDAVGDD SARRKHNENK LADKLRKTLL SRRYLILVDD VWDNSAWDDL
     RGCFPDANNR SRIILTTRHH EVAKYASVHS DPLHLRMFDE DESWKLLEKK VFGEKRCSSL
     LLKDVGLRIA KMCGQLPLSI VLVAGILSEM EKEVECWEQV ANNLGTHIHN DSRAIVNQSY
     HVLPCHLKSC FLYFGAFLED EVIDISRLIR LWISESFIKS SEGRRLEDIA EGYLENLIGR
     NLVMVTQRAD SDGKVKACRL HDVLLDFCKE RAAEENFLLW INRDQISTKA VYSHKQHAHL
     AFTEMDNLVE WSASCSLVGS VLFKNPDSYL YSPAFSTSLI LLNFKFLKVL DLEHQVVIDF
     IPTELFYLRY LSASIEQNSI PSSISNLWNL ETLILKSTPV GRHNTLLLPS TIWDMVKLRH
     LHIPKFSPEN EEALLENSAR LYDLETISTP YFSSVEDAEL ILRKTPNLRK LICEVECLEY
     PPQYHVLNFP IRLEILKLYR SKAFKTIPFC ISAPNLKYLK LSGFYLDSQY LSETVDHLKH
     LEVLKLCDLE FGDHREWKVS NGMFPQLKIL KLEYLSLMKW IVADDAFPNL EQLVLHGCQD
     LMEIPSCFMD ILSLKYIEVD MSNKSVVKSA KNIEETQVED NQNTNFKLVI IKKMVLKFDI
     YQNHDKGRLE TFKKLVPLPG VKSVRFDMDE KKVTVTGVMD ANEVQLVVSK LRKRGML
 
 
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