R1B14_SOLDE
ID R1B14_SOLDE Reviewed; 1317 AA.
AC Q6L3Z7;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Putative late blight resistance protein homolog R1B-14;
GN Name=R1B-14; ORFNames=PGEC858M02.15;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AC149265; AAT38776.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6L3Z7; -.
DR SMR; Q6L3Z7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1317
FT /note="Putative late blight resistance protein homolog R1B-
FT 14"
FT /id="PRO_0000233968"
FT DOMAIN 521..823
FT /note="NB-ARC"
FT REPEAT 944..968
FT /note="LRR 1"
FT REPEAT 987..1015
FT /note="LRR 2"
FT REPEAT 1090..1114
FT /note="LRR 3"
FT REPEAT 1138..1161
FT /note="LRR 4"
FT REPEAT 1164..1186
FT /note="LRR 5"
FT REPEAT 1187..1211
FT /note="LRR 6"
FT DOMAIN 1251..1317
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT COILED 419..442
FT /evidence="ECO:0000255"
FT COILED 535..556
FT /evidence="ECO:0000255"
FT BINDING 568..575
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1317 AA; 151458 MW; 5928CAB34CC33005 CRC64;
MYFNNELSGL KDRFLKSLLA QKYPDRINFF LWELKFLDCF LHLQNFAFAS ECGMLDVSQK
MLKNFKRMCA TFRSIRPNAG SDNAFAYLKE VICKRLCATL LNTRPDACSD DGFAYWNEVI
WKTKQEFRAK YSFPKTPLAS NKVDDDDINI HSPKFVMEFI DAVVGNLNVL VKINDPCSLL
FVPGPKEQID QVSKELKLLR FFVCFVSNKC IEPQYGHTTF YIHALIEASH IAMVVWLHLP
VYGNGNQDLA PSEVSRLLSD FISRNSNYID VLKALKSTIP QAQNKHAAES GIVETPTHNL
MVGLSDQMVN LQEMLCLLRD NLIHLPILDL EFHLQDMDSV ILDAGLLIYS LYDIEGEKED
TVLDDMNRAL GFDLPRNIEP IKVMVYLVMQ KAFQCNLPRV HGLGYVDFLL KNLNDFQGRY
SDSLAFLKNQ LQVIQTEFES LQPFLKVVIE EPHNKLKTLN EDCATQIIRK AYEVEYVVDA
CINKVAPHWC LERWLLDIIE EITCIKAKIQ EKNTVEDTMK TVITHTSSQL ARTPRMNEEI
VGFKDVIENL RNRLLNGTKG QDVISIHGMP GLGKTTLANR LYSDRSVVSH FDICAQCCVS
QVYSYKELLL ALLCDAVGDD SARRKHNENK LADKLRKTLL SRRYLILVDD VWDNSAWDDL
RGCFPDANNR SRIILTTRHH EVAKYASVHS DPLHLRMFDE DESWKLLEKK VFGEKRCSSL
LLKDVGLRIA KMCGQLPLSI VLVAGILSEM EKEVECWEQV ANNLGTHIHN DSRAIVNQSY
HVLPCHLKSC FLYFGAFLED EVIDISRLIR LWISESFIKS SEGRRLEDIA EGYLENLIGR
NLVMVTQRAD SDGKVKACRL HDVLLDFCKE RAAEENFLLW INRDQISTKA VYSHKQHAHL
AFTEMDNLVE WSASCSLVGS VLFKNPDSYL YSPAFSTSLI LLNFKFLKVL DLEHQVVIDF
IPTELFYLRY LSASIEQNSI PSSISNLWNL ETLILKSTPV GRHNTLLLPS TIWDMVKLRH
LHIPKFSPEN EEALLENSAR LYDLETISTP YFSSVEDAEL ILRKTPNLRK LICEVECLEY
PPQYHVLNFP IRLEILKLYR SKAFKTIPFC ISAPNLKYLK LSGFYLDSQY LSETVDHLKH
LEVLKLCDLE FGDHREWKVS NGMFPQLKIL KLEYLSLMKW IVADDAFPNL EQLVLHGCQD
LMEIPSCFMD ILSLKYIEVD MSNKSVVKSA KNIEETQVED NQNTNFKLVI IKKMVLKFDI
YQNHDKGRLE TFKKLVPLPG VKSVRFDMDE KKVTVTGVMD ANEVQLVVSK LRKRGML