R1B16_SOLDE
ID R1B16_SOLDE Reviewed; 1284 AA.
AC Q6L400;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Putative late blight resistance protein homolog R1B-16;
GN Name=R1B-16; ORFNames=PGEC858M02.12;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AC149265; AAT38773.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6L400; -.
DR SMR; Q6L400; -.
DR PRIDE; Q6L400; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1284
FT /note="Putative late blight resistance protein homolog R1B-
FT 16"
FT /id="PRO_0000233969"
FT DOMAIN 534..821
FT /note="NB-ARC"
FT REPEAT 942..966
FT /note="LRR 1"
FT REPEAT 985..1010
FT /note="LRR 2"
FT REPEAT 1013..1036
FT /note="LRR 3"
FT REPEAT 1085..1107
FT /note="LRR 4"
FT REPEAT 1108..1135
FT /note="LRR 5"
FT REPEAT 1159..1181
FT /note="LRR 6"
FT REPEAT 1182..1206
FT /note="LRR 7"
FT DOMAIN 1217..1284
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REPEAT 1219..1243
FT /note="LRR 8"
FT COILED 533..555
FT /evidence="ECO:0000255"
FT BINDING 567..574
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1284 AA; 148446 MW; CE7C87B2AD8AA886 CRC64;
MNFNNELSDL EKSFLFWTLR VQEYSYDTMH RIDFFLWELQ VLNCFLHLQS FTFASECGML
DISQKMLEIC KRFNTPPPHN AFAYWKELIC KRLCAISIRP DDGFAYWKKV IWKTKQEFRA
KYSFPKTLLA DNKVDDDDTN PEFVMEFIDA VVGNLNVLVK INDPSSLLFV PGPKEQIEQV
LKELKLLRFF VCFVSNKCIE PQYQHTTFYT HALIEASHIA MVVWLNLPIY GNRNQDLASS
EVSCLLSNFM EMKIKSIQPG ISRNNIYIDV LQALKSTIPQ AQKKHAAESG IVEIPTHSLM
VGLSDQMANL QEMLCLLKDN LIHLPILDLE FQPQDMDSVI IDAGLLIYSF YDMKGEKEDT
TLEDINRELG FDLSRNIEPI KVMIYLVMQK AFQCNLPRIH GLGYVDFLLK NLKDFQGRYS
DSFALHKTQI QVIQKEFESL QPFLKVVVEE PHNTFKRLSE DCAIQIIRKA HEVEYVVDAC
INKGIPHWRL KGWLQIIIED ITCIKEKIQE KNTVDDTMKT VIARTSSKLA RTPRMNEEIV
GFKDVIENLR NQLLNGTKGQ DAISIHGMPG LGKTTLANTL YSDRSVVSQF DICAQCCVSQ
VYSYKDLLLA LLCDAVGEDS DRRELPDNEL ADMLRKTLLP RRYLILVDDV WDNSAWDDLR
GCFPDVNNRS RIILTTRHHE VAKYASVHSD PLHLRMFDKD ESWKLLEKKV FGEQSCSPLL
KDVGLRIAKM CGQLPLSIVL VAGILSEMEK EVECWEQVAN NLGTHIHNDS RAIVNQSYHV
LPCHLKSCFL YFGAFLEDEV IDISRLIRLW ISESFIKSSE GRRLEDIAEG YLENLIGRNL
VMVTQRADSD GKVKACRLHD VLLDFCKERA AEENFLLWIN RDQSTNAVYS HKRHAHLAFT
EMDSLVEWSA SCSLVGSVLL KNYARRPLSS PAFSISHILL NFKFLKVLDL EHQVVIDSIP
TELFYLRYLS ARIEQNSIPS SISNLWNLET LILKHVSRCT VLLPSTVWDM VKLRHLHIPN
FRPENEEALL ENSAKLYDLE TLSTPYFSRV EDAELMLRKT PNLRKLVCEV ECLEYPPQYH
VLNFPIRLEI LKLYRSKAFN TIPFCISAPN LKYLKLSRSY MDSQYLSETA DHLKNLEVLK
LYFVKFADHR EWKVSNGMFP QLKILKLEYL ALMKWIVADD AFPNLEQLVL HECRHLMEIP
SCFMDIPSLK YIEVENCNES VVKSAMNIQE TQVEDYQNTN FKLVLIGIES ISTDTKEKKL
TVTRDVDADE VQLVVEKQRK RGML
