R1B17_SOLDE
ID R1B17_SOLDE Reviewed; 1312 AA.
AC Q6L403;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Putative late blight resistance protein homolog R1B-17;
GN Name=R1B-17; ORFNames=PGEC858M02.9;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AC149265; AAT38770.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6L403; -.
DR SMR; Q6L403; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1312
FT /note="Putative late blight resistance protein homolog R1B-
FT 17"
FT /id="PRO_0000233970"
FT DOMAIN 521..823
FT /note="NB-ARC"
FT REPEAT 944..968
FT /note="LRR 1"
FT REPEAT 990..1012
FT /note="LRR 2"
FT REPEAT 1087..1111
FT /note="LRR 3"
FT REPEAT 1115..1134
FT /note="LRR 4"
FT REPEAT 1135..1158
FT /note="LRR 5"
FT REPEAT 1161..1183
FT /note="LRR 6"
FT REPEAT 1184..1208
FT /note="LRR 7"
FT DOMAIN 1248..1312
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REPEAT 1273..1296
FT /note="LRR 8"
FT COILED 419..442
FT /evidence="ECO:0000255"
FT COILED 535..556
FT /evidence="ECO:0000255"
FT BINDING 568..575
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1312 AA; 150765 MW; 7AB02312D350E36D CRC64;
MYFNNELSGL KDRFLKSLLA QKYPDRINFF LWELKFLDCF LHLQNFAFAS ECGMLDVSQK
MLKNFKRMCA TFRSIRPNAG SDNAFAYLKE VICKRLCATL LNTRPDACSD DGFAYWNEVI
WKTKQEFRAK YSFPKTPLAS NKVDDDDINI HSPKFVMEFI DAVVGNLNVL VKINDPCSLL
FVPGPKEQID QVSKELKLLR FFVCFVSNKC IEPQYGHTTF YIHALIEASH IAMVVWLHLP
VYGNGNQDLA PSEVSRLLSD FISRNSNYID VLKALKSTIP QAQNKHAAES GIVETPTHNL
MVGLSDQMVN LQEMLCLLRD NLIHLPILDL EFHLQDMDSV ILDAGLLIYS LYDIEGEKED
TVLDDMNRAL GFDLPRNIEP IKVMVYLVMQ KAFQCNLPRV HGLGYVDFLL KNLNDFQGRY
SDSLAFLKNQ LQVIQTEFES LQPFLKVVIE EPHNKLKTLN EDCATQIIRK AYEVEYVVDA
CINKVAPHWC LERWLLDIIE EITCIKAKIQ EKNTVEDTMK TVITHTSSQL ARTPRMNEEI
VGFKDVIENL RNRLLNGTKG QDVISIHGMP GLGKTTLANR LYSDRSVVSH FDICAQCCVS
QVYSYKELLL ALLCDAVGDD SARRKHNENK LADKLRKTLL SRRYLILVDD VWDNSAWDDL
RGCFPDANNR SRIILTTRHH EVAKYASVHS DPLHLRMFDE DESWKLLEKK VFGEKRCSSL
LLKDVGLRIA KMCEQLPLSI VLVAGILSEM EKEVECWEQV ANNLGTHIHN DSRAIVNQSY
HVLPCHLKSC FLYFGAFLED EVIDISRLIR LWISESFIKS SEGRRLEDIA EGYLENLIGR
NLVMVTQRAD SDGKVKACRL HDVLLDFCKE RAAEENFLLW INRDQISTKA VYSHKQHAHL
AFTEMDNLVE WSASCSLVGS VLFKNPDSYL YSPAFSISLI LLNFKFLKVL DLERQVVIDF
IPTELFYLRY LSASIEQNSI PSSISNLWNL ETLILKGISA KTLLLPSTIW DMVKLRHLHI
PKFSPENDEA LLENSARLYD LETISTPYFS SVEHAELILR KTPNLRELIC EVECLEYPPQ
YHVLNFPIRL EILKLYRSKA FKTIPFCISA PNLKYLKLSG FYLDSQYLSE TADHLKHLEV
LKLCDLEFGD HREWKVSNGM FPQLKILKLE YLSLMKWIVA DDAFPNLEQL VLHGCQDLME
IPSCFMDILS LKYIEVDMSN KSVVKSAKNI EETQVEDNQN TNFKLVVIKK MMWKVDVGVN
KGRLETFKRL APLPGIKSVA FDFNKKKLTV TGDMDANEVQ LVVSKLRKRG ML
