R1B19_SOLDE
ID R1B19_SOLDE Reviewed; 1326 AA.
AC Q6L406; Q0KIS9; Q0KIT0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Putative late blight resistance protein homolog R1B-19;
GN Name=R1B-19; ORFNames=PGEC858M02.6, SDM1_44t00002, SDM1_44t00018;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABI34343.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABI34350.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC149265; ABI34350.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC149265; ABI34343.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q6L406; -.
DR PRIDE; Q6L406; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 5: Uncertain;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1326
FT /note="Putative late blight resistance protein homolog R1B-
FT 19"
FT /id="PRO_0000233971"
FT DOMAIN 611..864
FT /note="NB-ARC"
FT REPEAT 953..978
FT /note="LRR 1"
FT REPEAT 980..996
FT /note="LRR 2"
FT REPEAT 1027..1050
FT /note="LRR 3"
FT REPEAT 1053..1070
FT /note="LRR 4"
FT REPEAT 1071..1094
FT /note="LRR 5"
FT REPEAT 1098..1118
FT /note="LRR 6"
FT REPEAT 1119..1146
FT /note="LRR 7"
FT REPEAT 1167..1191
FT /note="LRR 8"
FT REPEAT 1208..1230
FT /note="LRR 9"
FT DOMAIN 1209..1278
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT COILED 421..444
FT /evidence="ECO:0000255"
FT COILED 536..558
FT /evidence="ECO:0000255"
FT COILED 749..770
FT /evidence="ECO:0000255"
FT BINDING 570..577
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1326 AA; 153813 MW; 6B9898E5B0F49DBA CRC64;
MNFNNELSDL KNRFLFRTLR VQEYSDVARD RIDFFIWELK FLNCVLHLQS FTFASECGML
DISQKMLEIC KRFNTPPPHN AFAYWKEVIC KRLCAISIRP DASSDDGFAC WKKVIWKTKQ
EFRAKYSFPK TLLADNKVYD DTNPKFVMEF IDAVVGNLNV LVKINDPSSL HFVPGPKEQI
EQVLKELKLL RFFVCFVSNK CTEPQYQYTT FYTHALIEAS HIAMVVWLNL PIYGNRNQDL
ASNEVSCLFS DFMEMKIKSI QPGISRNNIY INVLRALKST IPHAQDKHAA ESGIVETPTH
NLMVGLSDQM ANLQEMLCLL RDNLIHLPIL DLEFHLQDMD SVILDVGLLI YSFYDMKGEK
EDTTLEDINR ELGFDLPRNI EPIKAMVYLV MQKAFHCNLP RVHGLGYADF LLKNLKDFQG
RYSDSLAFLK NQLQVIQTEF ESLQPFLKVV VEEPHNKFKR LNEDCAIQII RKAHEVEYVV
DACINKGIPH WCLERWLQDI IEEITCIKAK IQEKNTVDDT MKTVIVRTSS KLARTPRMKE
EIVGFEDIIE NLRKKLLNGT KGQDVISIHG MPGLGKTTLA NRLYSDRSVV SQFDICAQCC
VSQVYSYKDL LLSLLCDTIG EESERRELPD NELADMLRKT LLPRRYLILV DDVWENSVWD
DLRGCFPDTN NRSRIILTTR HHEVAKYASV HIDPLHLRMF DENESWKFLE KNVFGEESCS
PLLRDVGQRI AKMCGQLPFS IVLVAGIPSE MEKEVECWEQ VANNLGTRIH NDSRAIVDQS
YHVLPCHLKS CFLYFAAFLE DVVIYISRLL RLWISEAFIK SSEGRSLEDI AEGYLENLIG
RNLVMVTQRA DSDGKVKTCR LHDVLLDFCK KRAAEENFLL WINRDLITKP FSCVYSHKQH
AHLAFTEMHN LVEWSASCSF VGSVVLSKKY EPYFSIDLYS FYDFAISRNL PNFKFLKVLD
LEHQVFIDFI PTELVYLKYF SAHIKQNSIP SSIYNLWNPE TLKLKRPRHV RRCTLLLPST
VWDMVKLRHL YIPDFSTENE EALLENSAKL YDLETLSTPY FSRYHVLNFP IRLEILKLYR
SKAFKTIPFC ISAPNLKYLK LSGFYLDSQY LSETADHLKN LEVLKLYYVE FGDHREWKVS
NGMFPQLKIL KLEYLSLMKW IVADDAFPNL EQLYIKVENC NELVVKSAMN IQETQVEDNQ
NTNFKLVLIE KKTLKLNLSH DEDIPKAFKR LFLCPGIESV STDRKEKKLT VTGDVDAGSS
ISCGETEKAW HARVVVPTCQ HKCGIVILLT SNELGLGREE RKKRRKRRKR RAIKEIIVDI
VGGDPY
