ID   R1B23_SOLDE             Reviewed;        1262 AA.
AC   Q6L3L0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Putative late blight resistance protein homolog R1B-23;
GN   Name=R1B-23; ORFNames=PGEC517A09.9;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
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DR   EMBL; AC149301; AAT39284.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L3L0; -.
DR   SMR; Q6L3L0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR021929; Late_blight_resistance_R1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT   CHAIN           1..1262
FT                   /note="Putative late blight resistance protein homolog R1B-
FT                   23"
FT                   /id="PRO_0000233972"
FT   DOMAIN          475..761
FT                   /note="NB-ARC"
FT   REPEAT          890..914
FT                   /note="LRR 1"
FT   REPEAT          933..961
FT                   /note="LRR 2"
FT   REPEAT          1036..1059
FT                   /note="LRR 3"
FT   REPEAT          1064..1083
FT                   /note="LRR 4"
FT   REPEAT          1084..1112
FT                   /note="LRR 5"
FT   REPEAT          1133..1157
FT                   /note="LRR 6"
FT   DOMAIN          1181..1248
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   COILED          364..384
FT                   /evidence="ECO:0000255"
FT   COILED          475..496
FT                   /evidence="ECO:0000255"
FT   BINDING         508..515
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1262 AA;  145960 MW;  3E3C91353E272403 CRC64;
     MIEFWKSEYT RILSICHDSG TQYRNKNVRM RSLYLEKVWV AFKSFAYWKE VIWKTKQEFR
     AQYSFPKTSL EANKVDDANT HSPKFVMEVI DVFVENLNDL MKINDPSSWL FVPGHMKEQI
     EKVLKELKLL RFFVCFVSNK CIQPQYQHTT FYTHALIEAS HNAMVVWLHL PVYGIGNQDL
     APSEVSRLLS DFMEMKIKSI QPGISRNSIY IDVLQALKST IPQAQQKHVA ESGIVEIPTH
     SLTVGLSDQM ANLQEMLCLL RDNLIHLPIL DLEFHLQDMD SVIVDAGLLI YSLYDIKGEK
     EDTILEDIKR ELGFDLPRNI EPIKVMVYLV MQKAFQCNLP RIHGLGYVDF LLKNLKDFQG
     RYSDSLAFLK NQLQVIQTKF ESMQPFLKVV VEEPHNKLKT LNEDCATQII RKAYEVEYVV
     DACINKEVPQ WCIERWLLDI IEEITCIKEK IQEKNTVEDT MKSVIASSQL ARTPRMNEEI
     VGFEDVIETL RKKLLNGTKG QDVISMHGMP GLGKTTLANR LYSDRSVVSQ FDICAQCCVS
     QVYSYKDLLL ALLRDAIGEG SVRTELHANE LADMLRKTLL PRRYLILVDD VWENSVWDDL
     SGCFPDVNNR SRIILTTRHH EVAKYASVHS DPLHLRMFDE VESWKLLEKK VFGEESCSPL
     LRDIGQRIAK MCGQLPLSIV LVAGILSEME KEVECWEQVA NNLGTHIHND SRAVVDQSYH
     VLPCHLKSCF LYFGAFLEDR VIDIPRLIRL WISESFIKSC EGRSLEDIAE GYLENLIGRN
     LVMVTQRDDS DGKVKACRLH DVLLDFCKER AAEENFLLWI NRDQITKPSS CVYSHNQHAH
     LAFTDMKNLV EWSASCSCVG SVLFKNYDPY FAGRPLSSHA FSISRILLNF KFLKVLDLEH
     QVVIDSIPTE LFYLRYISAH IEQNSIPSSI SNLWNLETLI LNRTSAATGK TLLLPSTVWD
     MVKLRHLHIP KFSPENKKAL LENSARLDDL ETLFNPYFTR VEDAELMLRK TPNLRKLICE
     VQCLEYPHQY HVLNFPIRLE MLKLHQSNIF KPISFCISAP NLKYLELSGF YLDSQYLSET
     ADHLKHLEVL KLYYVEFGDH REWKVSNGMF PQLKILKLKC VSLLKWIVAD DAFPNLEQLV
     LRRCRHLMEI PSCFMDILSL QYIEVENCNE SVVKSAMNIQ ETQVEDNQNT NFKLVLIEIH
     LFCLFDMKGI ESISTDMKEK KLTVTRDVDA DEVQLVVEKL RNVAYADEVQ LVVEKLRKRG
     ML