ID   R1B8_SOLDE              Reviewed;        1202 AA.
AC   Q6L3X3;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Putative late blight resistance protein homolog R1B-8;
GN   Name=R1B-8; ORFNames=PGEC747E24.10;
OS   Solanum demissum (Wild potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=50514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA   Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA   Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA   Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA   Buell C.R., Baker B.;
RT   "The R1 resistance gene cluster contains three groups of independently
RT   evolving, type I R1 homologues and shows substantial structural variation
RT   among haplotypes of Solanum demissum.";
RL   Plant J. 44:37-51(2005).
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is encoded by the haplotype B genome of the
CC       allohexaploid Solanum demissum.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC149267; AAT38800.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6L3X3; -.
DR   SMR; Q6L3X3; -.
DR   PRIDE; Q6L3X3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR021929; Late_blight_resistance_R1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF12061; NB-LRR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   5: Uncertain;
KW   ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW   Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT   CHAIN           1..1202
FT                   /note="Putative late blight resistance protein homolog R1B-
FT                   8"
FT                   /id="PRO_0000233964"
FT   DOMAIN          426..741
FT                   /note="NB-ARC"
FT   REPEAT          865..889
FT                   /note="LRR 1"
FT   REPEAT          908..936
FT                   /note="LRR 2"
FT   REPEAT          1011..1036
FT                   /note="LRR 3"
FT   REPEAT          1040..1059
FT                   /note="LRR 4"
FT   REPEAT          1060..1084
FT                   /note="LRR 5"
FT   REPEAT          1086..1111
FT                   /note="LRR 6"
FT   REPEAT          1128..1151
FT                   /note="LRR 7"
FT   COILED          345..368
FT                   /evidence="ECO:0000255"
FT   COILED          437..459
FT                   /evidence="ECO:0000255"
FT   BINDING         471..478
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1202 AA;  139403 MW;  E8725ECA779AD387 CRC64;
     MIEFWRSEYT RILSICPDPG KKYRNKNVRM WSLYLERVRE VIWKTKQEFK AEYSFPKTSL
     AANKVDDVSP KFVMEVMDVF VENLNVLMKI NDPCLWLFVP GHMKEQIEQV LKELKLLRFF
     VCFVSSKCIE PQYRRTTFYT HALIEASHNA MVVWLHLPVY GNKNQDLAPT EVSRLLSDFM
     EMKIKSIQPG NSIYIDVLQA LKSTIPQAQQ KHAAESGIVE IPIHSLTVGL SDQMANLQEM
     ICLLRDNLIH LPILDLEFHL QDMDSVILDA GLLIYSFYDI KGEKEDTMLE DINRALGFDL
     PRNIEPIKAM VYLVMQKAFQ CNLPRVHGLG YVDFLLKNLK DFQGRYSDSL AFLKNQLQVI
     QTEFESLQPF LKVVAEEPHN KLKTLNEDCA TQIIRKSYED IIEEITCIKA KIQEKNTVED
     TMKTVIARTS SQLARTLRMN EEIVGFEDVI EKLRNRLLNR TKGQDVISIH GMPGLGKTTL
     ANRLYSDMSV VSQFDICARC CVSQVYSYKD LLLSLIRDAI GENSDQHREL IRDAIGENSD
     QHRELCANEL ADKLRKTLLR RRYLILVDDV WENSVWDDLR GWFPDANNRS RIILMTRHHE
     VAKYASVHGD PLHLRMLDED ESWKLLEKKV FGEQSCSSPL LKNVGLRIAK MCGQLPLSIV
     LVAGILSEME KEVECWEQVA NNLGSHIHND SRAIVDQSYH VLPCHLKSCF LYFGAFLEDR
     VIDISRLIGL WISESFIKSC EGRRLEYIAE GYLENLIGRN LVMVTQRAIS DGKVKACRLH
     DVLLDFCKKR AAEENFLLWI NRDQSTKAVY SHKQHAHLAF TEMDNLVEWS ASCSLVGSVL
     FKSYDPYFRP LSSHAFAISH ILLNFKFLKV LDLEHQVIID FIPTELFYLR YLSAHIDQNS
     IPSSISNLWN LETLILKSRS ASKHNRVLLP STVWDMVKLR HLHIPYFSTE DEEALLENSA
     KLYDLETLSS PYFSRVEDAE LMLRRTPNLR KLICEVQCLE SPHQYHVLNF PIRLEILKLY
     NRSKAFKTIP FCISAPNLKY LKLSRFYLDS QYLSETADHL KHLEVLKLSC VEFGDHGEWE
     VSNGMFPQLK ILKLEYVSLM KWIVADDVFP NLEQLVLRGC RHLMEIPSCF MDILSLKYIK
     VDEYSESVVQ SARKIQETQI EEYQNNNFKL VIIKVHYREK LNELFSLLSL TVLGLVLHPI
     FL