R1C3_SOLDE
ID R1C3_SOLDE Reviewed; 1292 AA.
AC Q6L3N7;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Putative late blight resistance protein homolog R1C-3;
GN Name=R1C-3; ORFNames=PGEC568H16.16;
OS Solanum demissum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=50514;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16167894; DOI=10.1111/j.1365-313x.2005.02506.x;
RA Kuang H., Wei F., Marano M.R., Wirtz U., Wang X., Liu J., Shum W.P.,
RA Zaborsky J., Tallon L.J., Rensink W., Lobst S., Zhang P., Tornqvist C.-E.,
RA Tek A., Bamberg J., Helgeson J., Fry W., You F., Luo M.-C., Jiang J.,
RA Buell C.R., Baker B.;
RT "The R1 resistance gene cluster contains three groups of independently
RT evolving, type I R1 homologues and shows substantial structural variation
RT among haplotypes of Solanum demissum.";
RL Plant J. 44:37-51(2005).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: This protein is encoded by the haplotype C genome of the
CC allohexaploid Solanum demissum.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AC149291; AAT38759.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6L3N7; -.
DR SMR; Q6L3N7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR021929; Late_blight_resistance_R1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Hypersensitive response;
KW Leucine-rich repeat; Membrane; Nucleotide-binding; Plant defense; Repeat.
FT CHAIN 1..1292
FT /note="Putative late blight resistance protein homolog R1C-
FT 3"
FT /id="PRO_0000233973"
FT DOMAIN 505..792
FT /note="NB-ARC"
FT REPEAT 842..865
FT /note="LRR 1"
FT REPEAT 920..944
FT /note="LRR 2"
FT REPEAT 963..991
FT /note="LRR 3"
FT REPEAT 1066..1089
FT /note="LRR 4"
FT REPEAT 1094..1113
FT /note="LRR 5"
FT REPEAT 1114..1142
FT /note="LRR 6"
FT REPEAT 1163..1187
FT /note="LRR 7"
FT DOMAIN 1211..1278
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT COILED 394..414
FT /evidence="ECO:0000255"
FT COILED 505..526
FT /evidence="ECO:0000255"
FT BINDING 538..545
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1292 AA; 149778 MW; E20A54B549ADADAD CRC64;
MYFNNELSNL KDHLLVTLQN NSDVERDRIN FILWDLKFLD CFLHLKRLPF ASECGMLEFS
QKMIEIWKIQ SHREPYDCPY WKEVIWKTKQ EFRAEYSFPN TSLAANKVDD VSPKFVMEVI
DVFVENLNVV VKINDPYSWL FVPEHKEQIE QVLKELKLLR FFVCFVSNKC IEPQYRHTTF
YIHALIEASH IAMVVWLHLP VLNGIVNQYL APSEVSRLRS DFMEMKIKSI QPDISRNNIY
IDVLQALKST IPQAQNKHAV ESGIVETPTQ NLTVGLSDQM VNLQEMLCFL RDNLIHLPIL
DLEFHLQDMD SVIVDAGLLI YSLYDIKGEK EDTVLDNMNR ALGFDLPRNI EPIKAMVYLV
MQKAFQSNLP RVHGLGYVDF LLKNLKDFQG RYSDSLAFLK NQLQVIQTKF ESMQPFLKVV
VEEPHNKLKT LNEDYATQII RKAYEVEYVV DACINKEVPQ WCIERWLLDI IEEITCIKAK
IQEKNTVEDT MKSVIASSQL ARTPRMNEEI VGFEDVIETL RKKLLNGTKG QDVISMHGMP
GLGKTTLANR LYSDRSVVSQ FDICAQCCVS QVYSYKDLLL ALLRDAIGEG SVRTELHANE
LADMLRKTLL PRRYLILVDD VWENSVWDDL SGCFPDVNNR SRIILTTRHH EVAKYASVHS
DPLHLRMFDE VESWKLLEKK VFGEESCSPL LRDIGQRIAK MCGQLPLSIV LVAGILSEME
KEVEYWEQVA NNLGTHIHND SRAVVDQSYH VLPCHLKSCF LYFGAFLEDR VIDISRLIRL
WISESFVKSC EGRSLEDIAE GYLENLIGRN LVMVTQRDDS DGKVKACRLH DVLLDFCKER
AAEENFLLWI NRDQITKPSS CVYSHNQHAH LAFTDMKNLV EWSASCSRVG SVLFKNYDPY
FAGRPLSSHA FSISRILLNF KFLKVLDLEH QVVIDSIPTE LFYLRYISAH IEQNSIPSSI
SNLWNLETLI LNRTSAATGK TLLLPSTVWD MVKLRHLHIP KFSPENKKAL LKKSARLDDL
ETLFNPYFTR VEDAELMLRK TPNLRKLICE VQCLEYPHQY HVLNFPIRLE MLKLHQSNIF
NPISFCISAP NLKYLELSGF YLDSQYLSET ADHLKHLEVL KLYYVEFGDH REWKVSNGMF
PQLKILKLKC VSLLKWIVAD DAFPNLEQLV LRGCRHLMEI PSCFMDILSL QYIEVENCNE
SVVKSAMNIQ ETQVEDNQNT NFKLILIEIH LFYLFDMKGI ESISTDMKEK KLTVTRDVDA
DEVQLVVEKL RNVAYADEVQ LVVEKLRKRG ML
