R212B_HUMAN
ID R212B_HUMAN Reviewed; 300 AA.
AC A8MTL3;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=RING finger protein 212B;
GN Name=RNF212B; Synonyms=C14orf164;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-250.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SEQUENCE CAUTION:
CC Sequence=EB710205; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL117258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW66180.1; -; Genomic_DNA.
DR EMBL; EB710205; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS61401.1; -.
DR RefSeq; NP_001269251.1; NM_001282322.1.
DR RefSeq; XP_011534615.1; XM_011536313.2.
DR AlphaFoldDB; A8MTL3; -.
DR SMR; A8MTL3; -.
DR STRING; 9606.ENSP00000382794; -.
DR iPTMnet; A8MTL3; -.
DR PhosphoSitePlus; A8MTL3; -.
DR BioMuta; RNF212B; -.
DR MassIVE; A8MTL3; -.
DR PaxDb; A8MTL3; -.
DR PeptideAtlas; A8MTL3; -.
DR PRIDE; A8MTL3; -.
DR Antibodypedia; 64489; 5 antibodies from 5 providers.
DR DNASU; 100507650; -.
DR Ensembl; ENST00000399910.5; ENSP00000382794.1; ENSG00000215277.9.
DR Ensembl; ENST00000430154.7; ENSP00000397830.2; ENSG00000215277.9.
DR GeneID; 100507650; -.
DR KEGG; hsa:100507650; -.
DR MANE-Select; ENST00000430154.7; ENSP00000397830.2; NM_001282322.3; NP_001269251.1.
DR UCSC; uc058zpp.1; human.
DR CTD; 100507650; -.
DR GeneCards; RNF212B; -.
DR HGNC; HGNC:20438; RNF212B.
DR HPA; ENSG00000215277; Tissue enriched (kidney).
DR neXtProt; NX_A8MTL3; -.
DR OpenTargets; ENSG00000215277; -.
DR VEuPathDB; HostDB:ENSG00000215277; -.
DR eggNOG; KOG4739; Eukaryota.
DR GeneTree; ENSGT00740000115581; -.
DR HOGENOM; CLU_067832_0_0_1; -.
DR InParanoid; A8MTL3; -.
DR OMA; MQEAQQT; -.
DR OrthoDB; 1325661at2759; -.
DR PhylomeDB; A8MTL3; -.
DR TreeFam; TF319600; -.
DR PathwayCommons; A8MTL3; -.
DR SignaLink; A8MTL3; -.
DR BioGRID-ORCS; 100507650; 18 hits in 945 CRISPR screens.
DR ChiTaRS; RNF212B; human.
DR Pharos; A8MTL3; Tdark.
DR PRO; PR:A8MTL3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; A8MTL3; protein.
DR Bgee; ENSG00000215277; Expressed in kidney epithelium and 100 other tissues.
DR ExpressionAtlas; A8MTL3; baseline and differential.
DR Genevisible; A8MTL3; HS.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019789; F:SUMO transferase activity; IBA:GO_Central.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IBA:GO_Central.
DR GO; GO:0016925; P:protein sumoylation; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IEA:InterPro.
DR InterPro; IPR042123; Zip3/RNF212-like.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22663; PTHR22663; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..300
FT /note="RING finger protein 212B"
FT /id="PRO_0000349181"
FT ZN_FING 6..40
FT /note="RING-type"
FT REGION 141..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..124
FT /evidence="ECO:0000255"
FT COMPBIAS 141..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 227
FT /note="S -> T (in Ref. 3; EB710205)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="G -> E (in Ref. 3; EB710205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 33570 MW; A064DB5E3DCE0DFE CRC64;
MDWFHCNQCF RKDGAHFFVT SCGHIFCKKC VTLEKCAVCG TACKHLALSD NLKPQEKMFF
KSPVETALQY FSHISQVWSF QKKQTDLLIA FYKHRITKLE TAMQEAQQAL VSQDKELSVL
RKENGELKKF LAILKESPSR YQGSRSITPR PVGITSPSQS VTPRPSFQHS SQVVSRSSSA
ESIPYREAGF GSLGQGGRGL QGRRTPRDSY NETPSPASTH SLSYRTSSAS SGQGIFSFRP
SPNGHSGHTR VLTPNNFAQR ESTTTLESLP SFQLPVLQTL YQQRRHMGLP SGREAWTTSR
