ID   R2PLG_LITPA             Reviewed;          41 AA.
AC   D3UA80;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Ranatuerin-2PLg {ECO:0000312|EMBL:ACZ44727.1};
DE   Flags: Precursor; Fragment;
OS   Lithobates palustris (Pickerel frog) (Rana palustris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=298395;
RN   [1] {ECO:0000312|EMBL:ACZ44727.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20179920; DOI=10.1007/s00251-010-0430-7;
RA   Tennessen J.A., Blouin M.S.;
RT   "A revised leopard frog phylogeny allows a more detailed examination of
RT   adaptive evolution at ranatuerin-2 antimicrobial peptide loci.";
RL   Immunogenetics 62:333-343(2010).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:Q8QFQ4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8QFQ4}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ845479; ACZ44727.1; -; Genomic_DNA.
DR   AlphaFoldDB; D3UA80; -.
DR   SMR; D3UA80; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   3: Inferred from homology;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted.
FT   PROPEP          <1..11
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000413848"
FT   PEPTIDE         14..41
FT                   /note="Ranatuerin-2PLg"
FT                   /evidence="ECO:0000250|UniProtKB:Q8QFQ4"
FT                   /id="PRO_5000578146"
FT   DISULFID        36..41
FT                   /evidence="ECO:0000250|UniProtKB:Q1JS92"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:ACZ44727.1"
SQ   SEQUENCE   41 AA;  4481 MW;  4362D5AB73CA87AC CRC64;
     DDGVEMTEEE VKRGIMDTVK NAAKDLAGQL LDKLKCKITA C