ID   R3GEF_BOVIN             Reviewed;         390 AA.
AC   Q2KJ58;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Guanine nucleotide exchange factor for Rab-3A;
DE   AltName: Full=Rab-3A-interacting-like protein 1;
DE            Short=Rab3A-interacting-like protein 1;
DE   AltName: Full=Rabin3-like 1;
GN   Name=RAB3IL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate
CC       RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes
CC       the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins
CC       into their active GTP-bound form. May also activate RAB8A and RAB8B (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RAB3A and IHPK1 through the coiled-coil domain.
CC       This interaction is competitive. IHPK1 kinase activity is not required
CC       for this interaction (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC2 family. {ECO:0000305}.
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DR   EMBL; BC105507; AAI05508.1; -; mRNA.
DR   RefSeq; NP_001039997.1; NM_001046532.1.
DR   AlphaFoldDB; Q2KJ58; -.
DR   SMR; Q2KJ58; -.
DR   STRING; 9913.ENSBTAP00000020909; -.
DR   PaxDb; Q2KJ58; -.
DR   PRIDE; Q2KJ58; -.
DR   Ensembl; ENSBTAT00000020909; ENSBTAP00000020909; ENSBTAG00000015745.
DR   GeneID; 614335; -.
DR   KEGG; bta:614335; -.
DR   CTD; 5866; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015745; -.
DR   VGNC; VGNC:33655; RAB3IL1.
DR   eggNOG; KOG4324; Eukaryota.
DR   GeneTree; ENSGT00940000159102; -.
DR   HOGENOM; CLU_038204_1_0_1; -.
DR   InParanoid; Q2KJ58; -.
DR   OrthoDB; 619794at2759; -.
DR   TreeFam; TF313748; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000015745; Expressed in ureter and 103 other tissues.
DR   ExpressionAtlas; Q2KJ58; baseline.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR040351; RAB3IL/RAB3IP/Sec2.
DR   InterPro; IPR009449; Sec2_N.
DR   PANTHER; PTHR14430; PTHR14430; 1.
DR   Pfam; PF06428; Sec2p; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..390
FT                   /note="Guanine nucleotide exchange factor for Rab-3A"
FT                   /id="PRO_0000305294"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          73..161
FT                   /evidence="ECO:0000255"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBN0"
FT   MOD_RES         179
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBN0"
SQ   SEQUENCE   390 AA;  43325 MW;  2FF74675A081CBF1 CRC64;
     MWSGQPHPDE GHPPPLEAVP VPWKSVGPCK SHRESLGGLP ETPAGEEAQG EEGPAATQLD
     VSRLRSSSME IREKGSEFLK EELHKAQKEL KLKDEECERL SKVREQLEQE LEELTASLFE
     EAHKMVREAN MKQAASEKQL KEARGKIDML QAEVTALKTL VITSTPASPN RELHPQLLSP
     TKAGPRKGHL RHKSTSSALC PAVCPVAGHI LTPDKEGKEV DTTLFAEFQA WRESPTLDKT
     SPFLERVYRE DVGPCLDFTM QELSALVRAA VEDNTLTIEP VASQTLPAVK VAAVDCGHTN
     GFRAPIDTTC ALSGLACACR HRIRLGDSES HYYISPSSRA RITAVCNFFT YIRYIQQGLV
     RQDAEPMFWE ITRLRKEMSL AKLGFFPHEA