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R3HC1_MOUSE
ID   R3HC1_MOUSE             Reviewed;         488 AA.
AC   Q8BSI6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 3.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=R3H and coiled-coil domain-containing protein 1 {ECO:0000312|MGI:MGI:1919093};
GN   Name=R3hcc1 {ECO:0000312|MGI:MGI:1919093};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Wolffian duct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- CAUTION: Ribosome profiling data indicate that translation initiates
CC       from the non-AUG (CUG) codon used here. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC28055.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE33872.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK032854; BAC28055.1; ALT_INIT; mRNA.
DR   EMBL; AK156843; BAE33872.1; ALT_INIT; mRNA.
DR   EMBL; AC160639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS49533.2; -.
DR   RefSeq; NP_001139484.2; NM_001146012.2.
DR   RefSeq; NP_001288581.1; NM_001301652.1.
DR   AlphaFoldDB; Q8BSI6; -.
DR   SMR; Q8BSI6; -.
DR   STRING; 10090.ENSMUSP00000113450; -.
DR   iPTMnet; Q8BSI6; -.
DR   PhosphoSitePlus; Q8BSI6; -.
DR   EPD; Q8BSI6; -.
DR   jPOST; Q8BSI6; -.
DR   PaxDb; Q8BSI6; -.
DR   PRIDE; Q8BSI6; -.
DR   ProteomicsDB; 301909; -.
DR   Antibodypedia; 5331; 32 antibodies from 11 providers.
DR   Ensembl; ENSMUST00000118374; ENSMUSP00000113450; ENSMUSG00000034194.
DR   Ensembl; ENSMUST00000121142; ENSMUSP00000113898; ENSMUSG00000034194.
DR   GeneID; 71843; -.
DR   KEGG; mmu:71843; -.
DR   UCSC; uc007ump.3; mouse.
DR   CTD; 203069; -.
DR   MGI; MGI:1919093; R3hcc1.
DR   eggNOG; KOG4483; Eukaryota.
DR   GeneTree; ENSGT00530000063711; -.
DR   InParanoid; Q8BSI6; -.
DR   OMA; HPGKYRG; -.
DR   OrthoDB; 844916at2759; -.
DR   BioGRID-ORCS; 71843; 5 hits in 69 CRISPR screens.
DR   PRO; PR:Q8BSI6; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q8BSI6; protein.
DR   Bgee; ENSMUSG00000034194; Expressed in undifferentiated genital tubercle and 245 other tissues.
DR   ExpressionAtlas; Q8BSI6; baseline and differential.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.30.1370.50; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR039884; R3HC1/R3HCL.
DR   PANTHER; PTHR21678; PTHR21678; 1.
DR   Pfam; PF01424; R3H; 1.
DR   SMART; SM00393; R3H; 1.
DR   SUPFAM; SSF82708; SSF82708; 1.
DR   PROSITE; PS51061; R3H; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..488
FT                   /note="R3H and coiled-coil domain-containing protein 1"
FT                   /id="PRO_0000307390"
FT   DOMAIN          16..81
FT                   /note="R3H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT   REGION          87..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          244..321
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        163..177
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..268
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..322
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         232
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3T6"
SQ   SEQUENCE   488 AA;  54163 MW;  1BBBFFC42980601D CRC64;
     MALLCLDGVF LSSAENDFVH RVQEELDRFL LQKQLSKVLL FPPVSSRLRY LIHRTAENFD
     LLSSFSVGEG WKRRTVICHL DIRVPSSDGP SGPCRPPASH PSKYRGPRYT SHQGAAAGPR
     GAPAGRWHRG RKPDQPLYVP RVLRRQGGPV AASIPGIKGE DPAGAVSEEE PREAGAGDAE
     ADQGIAMLVT QELLKSPDPG HANEPQMGLG DTEPSENPEK EQGAETAVQQ GSGAQLAMEE
     ENRSHGMRSL VDQEEEEIEG EEEEKVDEKE EDTGKQKERV DEEEEKTDAQ EGKVDSEGER
     MDEGEDKVDA EEEDEDEADA DHGDFSELLQ EITANLTEKE IKIEKIHLDT SAFTEELPGE
     RDLTHLVEIY DFKPTLKTED LLATFSEFQE KGFRIQWVDD THAIGIFPCP ASALEALAKD
     FSVLKIRPLT QGTKQSKLKA LQRPKFLRLS KERPQTDSAV ARRLVARALG LQHNRKKELP
     TPPSVLPS
 
 
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