R3HD1_HUMAN
ID R3HD1_HUMAN Reviewed; 1099 AA.
AC Q15032; A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; Q8IW32;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=R3H domain-containing protein 1;
GN Name=R3HDM1; Synonyms=KIAA0029, R3HDM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Bone marrow;
RX PubMed=7584026; DOI=10.1093/dnares/1.1.27;
RA Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S.,
RA Nagase T., Seki N., Ishikawa K., Tabata S.;
RT "Prediction of the coding sequences of unidentified human genes. I. The
RT coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of
RT randomly sampled cDNA clones from human immature myeloid cell line KG-1.";
RL DNA Res. 1:27-35(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), AND VARIANT
RP PRO-632.
RC TISSUE=Brain, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT VAL-270.
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=15144186; DOI=10.1021/ac035352d;
RA Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,
RA Peters E.C.;
RT "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from
RT human T cells using immobilized metal affinity chromatography and tandem
RT mass spectrometry.";
RL Anal. Chem. 76:2763-2772(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187 AND SER-381, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187; SER-262; SER-302;
RP SER-381; SER-393 AND SER-973, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-929, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- INTERACTION:
CC Q15032-2; P54253: ATXN1; NbExp=3; IntAct=EBI-10966812, EBI-930964;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q15032-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15032-2; Sequence=VSP_017344, VSP_017345, VSP_054310;
CC Name=3;
CC IsoId=Q15032-3; Sequence=VSP_054310;
CC Name=4;
CC IsoId=Q15032-4; Sequence=VSP_054308, VSP_054309, VSP_054310;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA04878.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; D21852; BAA04878.2; ALT_INIT; mRNA.
DR EMBL; AK127793; BAG54571.1; -; mRNA.
DR EMBL; AK290015; BAF82704.1; -; mRNA.
DR EMBL; AC011893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471058; EAX11627.1; -; Genomic_DNA.
DR EMBL; BC041093; AAH41093.1; -; mRNA.
DR CCDS; CCDS2177.1; -. [Q15032-1]
DR CCDS; CCDS63024.1; -. [Q15032-4]
DR CCDS; CCDS63025.1; -. [Q15032-3]
DR CCDS; CCDS63026.1; -. [Q15032-2]
DR RefSeq; NP_001269727.1; NM_001282798.1. [Q15032-3]
DR RefSeq; NP_001269728.1; NM_001282799.1. [Q15032-2]
DR RefSeq; NP_001269729.1; NM_001282800.1. [Q15032-4]
DR RefSeq; NP_056176.2; NM_015361.3. [Q15032-1]
DR RefSeq; XP_006712452.1; XM_006712389.2.
DR RefSeq; XP_016859207.1; XM_017003718.1.
DR AlphaFoldDB; Q15032; -.
DR SMR; Q15032; -.
DR BioGRID; 117065; 76.
DR IntAct; Q15032; 19.
DR MINT; Q15032; -.
DR STRING; 9606.ENSP00000387010; -.
DR GlyGen; Q15032; 1 site, 2 O-linked glycans (1 site).
DR iPTMnet; Q15032; -.
DR PhosphoSitePlus; Q15032; -.
DR BioMuta; R3HDM1; -.
DR DMDM; 92086999; -.
DR EPD; Q15032; -.
DR jPOST; Q15032; -.
DR MassIVE; Q15032; -.
DR MaxQB; Q15032; -.
DR PaxDb; Q15032; -.
DR PeptideAtlas; Q15032; -.
DR PRIDE; Q15032; -.
DR ProteomicsDB; 19186; -.
DR ProteomicsDB; 20240; -.
DR ProteomicsDB; 33934; -.
DR ProteomicsDB; 60381; -. [Q15032-1]
DR ProteomicsDB; 60382; -. [Q15032-2]
DR Antibodypedia; 51003; 14 antibodies from 9 providers.
DR DNASU; 23518; -.
DR Ensembl; ENST00000264160.8; ENSP00000264160.4; ENSG00000048991.17. [Q15032-1]
DR Ensembl; ENST00000409478.5; ENSP00000386457.1; ENSG00000048991.17. [Q15032-2]
DR Ensembl; ENST00000409606.5; ENSP00000387010.1; ENSG00000048991.17. [Q15032-3]
DR Ensembl; ENST00000410054.5; ENSP00000386877.1; ENSG00000048991.17. [Q15032-4]
DR Ensembl; ENST00000628915.2; ENSP00000486837.1; ENSG00000048991.17. [Q15032-2]
DR GeneID; 23518; -.
DR KEGG; hsa:23518; -.
DR UCSC; uc002tuo.5; human. [Q15032-1]
DR CTD; 23518; -.
DR DisGeNET; 23518; -.
DR GeneCards; R3HDM1; -.
DR HGNC; HGNC:9757; R3HDM1.
DR HPA; ENSG00000048991; Low tissue specificity.
DR MIM; 619474; gene.
DR neXtProt; NX_Q15032; -.
DR OpenTargets; ENSG00000048991; -.
DR PharmGKB; PA34098; -.
DR VEuPathDB; HostDB:ENSG00000048991; -.
DR eggNOG; KOG2953; Eukaryota.
DR GeneTree; ENSGT00940000156095; -.
DR HOGENOM; CLU_007817_0_0_1; -.
DR InParanoid; Q15032; -.
DR OMA; ACYCAPS; -.
DR OrthoDB; 137913at2759; -.
DR PhylomeDB; Q15032; -.
DR TreeFam; TF315915; -.
DR PathwayCommons; Q15032; -.
DR SignaLink; Q15032; -.
DR BioGRID-ORCS; 23518; 15 hits in 1077 CRISPR screens.
DR ChiTaRS; R3HDM1; human.
DR GenomeRNAi; 23518; -.
DR Pharos; Q15032; Tdark.
DR PRO; PR:Q15032; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q15032; protein.
DR Bgee; ENSG00000048991; Expressed in middle temporal gyrus and 218 other tissues.
DR ExpressionAtlas; Q15032; baseline and differential.
DR Genevisible; Q15032; HS.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR Gene3D; 3.30.1370.50; -; 1.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR024771; SUZ.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF12752; SUZ; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51673; SUZ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..1099
FT /note="R3H domain-containing protein 1"
FT /id="PRO_0000097139"
FT DOMAIN 168..231
FT /note="R3H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT DOMAIN 232..302
FT /note="SUZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01009"
FT REGION 111..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..532
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..614
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 262
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 302
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 380
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 929
FT /note="Asymmetric dimethylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 929
FT /note="Omega-N-methylarginine; alternate"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 973
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..44
FT /note="MRMSDTVTVKDETATMKDLEAEVKDTTRVENLIKSENYGKILVE -> MGLL
FT LPDYRWFTTVDILADNCEKEPWIILFYFCGTPQSQIQRTH (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054308"
FT VAR_SEQ 45..100
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054309"
FT VAR_SEQ 57..100
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7584026"
FT /id="VSP_017344"
FT VAR_SEQ 406..490
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7584026"
FT /id="VSP_017345"
FT VAR_SEQ 541
FT /note="Q -> QQ (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:7584026"
FT /id="VSP_054310"
FT VARIANT 270
FT /note="M -> V (in dbSNP:rs961360)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025423"
FT VARIANT 632
FT /note="Q -> P (in dbSNP:rs2305165)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_025424"
FT CONFLICT 125
FT /note="K -> E (in Ref. 2; BAF82704)"
FT /evidence="ECO:0000305"
FT CONFLICT 902
FT /note="K -> R (in Ref. 2; BAF82704)"
FT /evidence="ECO:0000305"
FT CONFLICT 1075
FT /note="S -> L (in Ref. 2; BAF82704)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1099 AA; 120696 MW; 67782B9163702174 CRC64;
MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK
DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI
PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS
QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP
PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR
PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI
QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ
QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN
PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST
LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH
GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD
PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK
LRTSKKHYDF HILERASSQ
