R3HD2_HUMAN
ID R3HD2_HUMAN Reviewed; 976 AA.
AC Q9Y2K5; B7ZL65; Q2M1T9; Q3ZCT5;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=R3H domain-containing protein 2;
GN Name=R3HDM2; Synonyms=KIAA1002;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 321-976 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-853, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; SER-330; SER-349 AND
RP SER-855, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [10]
RP STRUCTURE BY NMR OF 147-257.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the R3H domain from human.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q9Y2K5; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-948428, EBI-10173507;
CC Q9Y2K5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-948428, EBI-3867333;
CC Q9Y2K5; Q0VD86: INCA1; NbExp=3; IntAct=EBI-948428, EBI-6509505;
CC Q9Y2K5; Q15323: KRT31; NbExp=3; IntAct=EBI-948428, EBI-948001;
CC Q9Y2K5; O76011: KRT34; NbExp=3; IntAct=EBI-948428, EBI-1047093;
CC Q9Y2K5; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-948428, EBI-11959885;
CC Q9Y2K5; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-948428, EBI-11749135;
CC Q9Y2K5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-948428, EBI-10172290;
CC Q9Y2K5; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-948428, EBI-10171774;
CC Q9Y2K5; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-948428, EBI-11953334;
CC Q9Y2K5; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-948428, EBI-10241252;
CC Q9Y2K5; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-948428, EBI-739863;
CC Q9Y2K5; A8MW99: MEI4; NbExp=3; IntAct=EBI-948428, EBI-19944212;
CC Q9Y2K5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-948428, EBI-22310682;
CC Q9Y2K5; O43610: SPRY3; NbExp=3; IntAct=EBI-948428, EBI-12290641;
CC Q9Y2K5; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-948428, EBI-5235829;
CC Q9Y2K5-2; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-10326419, EBI-946029;
CC Q9Y2K5-2; Q92567: FAM168A; NbExp=3; IntAct=EBI-10326419, EBI-7957930;
CC Q9Y2K5-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10326419, EBI-10171774;
CC Q9Y2K5-2; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10326419, EBI-751260;
CC Q9Y2K5-2; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10326419, EBI-945833;
CC Q9Y2K5-2; Q93062: RBPMS; NbExp=3; IntAct=EBI-10326419, EBI-740322;
CC Q9Y2K5-2; Q04864: REL; NbExp=3; IntAct=EBI-10326419, EBI-307352;
CC Q9Y2K5-2; O43609: SPRY1; NbExp=3; IntAct=EBI-10326419, EBI-3866665;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9Y2K5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y2K5-2; Sequence=VSP_026087, VSP_026088;
CC Name=3;
CC IsoId=Q9Y2K5-3; Sequence=VSP_057391, VSP_057392;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI04996.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI12227.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA76846.2; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB023219; BAA76846.2; ALT_FRAME; mRNA.
DR EMBL; AC126614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC137834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC041857; AAH41857.1; -; mRNA.
DR EMBL; BC104995; AAI04996.2; ALT_INIT; mRNA.
DR EMBL; BC112226; AAI12227.2; ALT_INIT; mRNA.
DR EMBL; BC143605; AAI43606.1; -; mRNA.
DR CCDS; CCDS8937.2; -. [Q9Y2K5-1]
DR RefSeq; NP_001317050.1; NM_001330121.1.
DR RefSeq; NP_001317051.1; NM_001330122.1.
DR RefSeq; NP_001317052.1; NM_001330123.1.
DR RefSeq; NP_055740.3; NM_014925.4. [Q9Y2K5-1]
DR RefSeq; XP_016874520.1; XM_017019031.1. [Q9Y2K5-3]
DR RefSeq; XP_016874521.1; XM_017019032.1.
DR RefSeq; XP_016874522.1; XM_017019033.1.
DR PDB; 1WHR; NMR; -; A=147-257.
DR PDBsum; 1WHR; -.
DR AlphaFoldDB; Q9Y2K5; -.
DR BMRB; Q9Y2K5; -.
DR SMR; Q9Y2K5; -.
DR BioGRID; 116532; 124.
DR IntAct; Q9Y2K5; 33.
DR STRING; 9606.ENSP00000317903; -.
DR GlyGen; Q9Y2K5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Y2K5; -.
DR PhosphoSitePlus; Q9Y2K5; -.
DR BioMuta; R3HDM2; -.
DR DMDM; 148887413; -.
DR EPD; Q9Y2K5; -.
DR jPOST; Q9Y2K5; -.
DR MassIVE; Q9Y2K5; -.
DR MaxQB; Q9Y2K5; -.
DR PaxDb; Q9Y2K5; -.
DR PeptideAtlas; Q9Y2K5; -.
DR PRIDE; Q9Y2K5; -.
DR ProteomicsDB; 7212; -.
DR ProteomicsDB; 85824; -. [Q9Y2K5-1]
DR ProteomicsDB; 85825; -. [Q9Y2K5-2]
DR Antibodypedia; 28556; 50 antibodies from 16 providers.
DR DNASU; 22864; -.
DR Ensembl; ENST00000347140.7; ENSP00000317903.6; ENSG00000179912.21. [Q9Y2K5-1]
DR Ensembl; ENST00000358907.6; ENSP00000351784.2; ENSG00000179912.21. [Q9Y2K5-1]
DR Ensembl; ENST00000441731.6; ENSP00000408536.2; ENSG00000179912.21. [Q9Y2K5-3]
DR GeneID; 22864; -.
DR KEGG; hsa:22864; -.
DR UCSC; uc001sns.3; human. [Q9Y2K5-1]
DR UCSC; uc001snu.3; human.
DR CTD; 22864; -.
DR DisGeNET; 22864; -.
DR GeneCards; R3HDM2; -.
DR HGNC; HGNC:29167; R3HDM2.
DR HPA; ENSG00000179912; Low tissue specificity.
DR neXtProt; NX_Q9Y2K5; -.
DR OpenTargets; ENSG00000179912; -.
DR PharmGKB; PA143485590; -.
DR VEuPathDB; HostDB:ENSG00000179912; -.
DR eggNOG; KOG2953; Eukaryota.
DR GeneTree; ENSGT00940000155609; -.
DR InParanoid; Q9Y2K5; -.
DR OrthoDB; 137913at2759; -.
DR PhylomeDB; Q9Y2K5; -.
DR TreeFam; TF315915; -.
DR PathwayCommons; Q9Y2K5; -.
DR SignaLink; Q9Y2K5; -.
DR BioGRID-ORCS; 22864; 15 hits in 1078 CRISPR screens.
DR ChiTaRS; R3HDM2; human.
DR EvolutionaryTrace; Q9Y2K5; -.
DR GenomeRNAi; 22864; -.
DR Pharos; Q9Y2K5; Tdark.
DR PRO; PR:Q9Y2K5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9Y2K5; protein.
DR Bgee; ENSG00000179912; Expressed in Brodmann (1909) area 10 and 207 other tissues.
DR ExpressionAtlas; Q9Y2K5; baseline and differential.
DR Genevisible; Q9Y2K5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR Gene3D; 3.30.1370.50; -; 1.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR024771; SUZ.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51673; SUZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..976
FT /note="R3H domain-containing protein 2"
FT /id="PRO_0000050787"
FT DOMAIN 169..232
FT /note="R3H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT DOMAIN 233..310
FT /note="SUZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01009"
FT REGION 32..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TM6"
FT MOD_RES 330
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 333
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TM6"
FT MOD_RES 349
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 853
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 855
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 856
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80TM6"
FT MOD_RES 860
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80TM6"
FT VAR_SEQ 1..339
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_057391"
FT VAR_SEQ 1..295
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026087"
FT VAR_SEQ 296..298
FT /note="QIF -> MIT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026088"
FT VAR_SEQ 434
FT /note="Q -> QPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNM (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_057392"
FT VARIANT 35
FT /note="T -> A (in dbSNP:rs11832661)"
FT /id="VAR_059713"
FT CONFLICT 359
FT /note="G -> S (in Ref. 3; AAH41857)"
FT /evidence="ECO:0000305"
FT HELIX 154..164
FT /evidence="ECO:0007829|PDB:1WHR"
FT TURN 166..168
FT /evidence="ECO:0007829|PDB:1WHR"
FT HELIX 169..184
FT /evidence="ECO:0007829|PDB:1WHR"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:1WHR"
FT HELIX 198..211
FT /evidence="ECO:0007829|PDB:1WHR"
FT STRAND 215..217
FT /evidence="ECO:0007829|PDB:1WHR"
FT STRAND 222..227
FT /evidence="ECO:0007829|PDB:1WHR"
FT HELIX 239..241
FT /evidence="ECO:0007829|PDB:1WHR"
SQ SEQUENCE 976 AA; 106999 MW; D626918F71E0F815 CRC64;
MSNSNTTQET LEIMKESEKK LVEESVNKNK FISKTPSKEE IEKECEDTSL RQETQRRTSN
HGHARKRAKS NSKLKLVRSL AVCEESSTPF ADGPLETQDI IQLHISCPSD KEEEKSTKDV
SEKEDKDKNK EKIPRKMLSR DSSQEYTDST GIDLHEFLVN TLKKNPRDRM MLLKLEQEIL
EFINDNNNQF KKFPQMTSYH RMLLHRVAAY FGMDHNVDQT GKAVIINKTS NTRIPEQRFS
EHIKDEKNTE FQQRFILKRD DASMDRDDNQ TGQNGYLNDI RLSKEAFSSS SHKRRQIFRG
NREGLSRTSS SRQSSTDSEL KSLEPRPWSS TDSDGSVRSM RPPVTKASSF SGISILTRGD
SIGSSKGGSA GRISRPGMAL GAPEVCNQVT SSQSVRGLLP CTAQQQQQQQ QQQLPALPPT
PQQQPPLNNH MISQADDLSN PFGQMSLSRQ GSTEAADPSA ALFQTPLISQ HPQQTSFIMA
STGQPLPTSN YSTSSHAPPT QQVLPPQGYM QPPQQIQVSY YPPGQYPNSN QQYRPLSHPV
AYSPQRGQQL PQPSQQPGLQ PMMPNQQQAA YQGMIGVQQP QNQGLLSSQR SSMGGQMQGL
VVQYTPLPSY QVPVGSDSQN VVQPPFQQPM LVPVSQSVQG GLPAAGVPVY YSMIPPAQQN
GTSPSVGFLQ PPGSEQYQMP QSPSPCSPPQ MPQQYSGVSP SGPGVVVMQL NVPNGPQPPQ
NPSMVQWSHC KYYSMDQRGQ KPGDLYSPDS SPQANTQMSS SPVTSPTQSP APSPVTSLSS
VCTGLSPLPV LTQFPRPGGP AQGDGRYSLL GQPLQYNLSI CPPLLHGQST YTVHQGQSGL
KHGNRGKRQA LKSASTDLGT ADVVLGRVLE VTDLPEGITR TEADKLFTQL AMSGAKIQWL
KDAQGLPGGG GGDNSGTAEN GRHSDLAALY TIVAVFPSPL AAQNASLRLN NSVSRFKLRM
AKKNYDLRIL ERASSQ
