R3HD2_MOUSE
ID R3HD2_MOUSE Reviewed; 1044 AA.
AC Q80TM6; Q80YB1; Q8BLS5; Q9CW50;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=R3H domain-containing protein 2;
GN Name=R3hdm2; Synonyms=Kiaa1002;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 289-1044 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-1044 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-1044 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-365; THR-924 AND
RP THR-928, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q80TM6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80TM6-2; Sequence=VSP_010553, VSP_010554;
CC Name=3;
CC IsoId=Q80TM6-3; Sequence=VSP_010553;
CC Name=4;
CC IsoId=Q80TM6-4; Sequence=VSP_010555, VSP_010556;
CC -!- SEQUENCE CAUTION:
CC Sequence=AK043545; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB23642.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC65698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK122416; BAC65698.1; ALT_INIT; mRNA.
DR EMBL; AK004884; BAB23642.2; ALT_INIT; mRNA.
DR EMBL; AK043545; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC043083; AAH43083.1; -; mRNA.
DR EMBL; BC064442; AAH64442.1; -; mRNA.
DR CCDS; CCDS24241.1; -. [Q80TM6-4]
DR CCDS; CCDS48717.1; -. [Q80TM6-1]
DR CCDS; CCDS88102.1; -. [Q80TM6-3]
DR RefSeq; NP_001161764.1; NM_001168292.1. [Q80TM6-1]
DR RefSeq; NP_082176.4; NM_027900.4. [Q80TM6-4]
DR RefSeq; XP_006514215.1; XM_006514152.2. [Q80TM6-1]
DR RefSeq; XP_006514216.1; XM_006514153.2. [Q80TM6-1]
DR RefSeq; XP_006514217.1; XM_006514154.3. [Q80TM6-1]
DR RefSeq; XP_006514218.1; XM_006514155.3.
DR RefSeq; XP_006514219.1; XM_006514156.3. [Q80TM6-1]
DR RefSeq; XP_006514220.1; XM_006514157.2. [Q80TM6-1]
DR RefSeq; XP_006514221.1; XM_006514158.2. [Q80TM6-3]
DR RefSeq; XP_006514225.1; XM_006514162.2. [Q80TM6-2]
DR RefSeq; XP_017169592.1; XM_017314103.1.
DR AlphaFoldDB; Q80TM6; -.
DR BMRB; Q80TM6; -.
DR SMR; Q80TM6; -.
DR BioGRID; 214898; 5.
DR STRING; 10090.ENSMUSP00000128659; -.
DR iPTMnet; Q80TM6; -.
DR PhosphoSitePlus; Q80TM6; -.
DR EPD; Q80TM6; -.
DR jPOST; Q80TM6; -.
DR MaxQB; Q80TM6; -.
DR PaxDb; Q80TM6; -.
DR PeptideAtlas; Q80TM6; -.
DR PRIDE; Q80TM6; -.
DR ProteomicsDB; 253136; -. [Q80TM6-1]
DR ProteomicsDB; 253137; -. [Q80TM6-2]
DR ProteomicsDB; 253138; -. [Q80TM6-3]
DR ProteomicsDB; 253139; -. [Q80TM6-4]
DR DNASU; 71750; -.
DR Ensembl; ENSMUST00000064793; ENSMUSP00000069724; ENSMUSG00000025404. [Q80TM6-4]
DR Ensembl; ENSMUST00000077046; ENSMUSP00000076303; ENSMUSG00000025404. [Q80TM6-1]
DR Ensembl; ENSMUST00000105249; ENSMUSP00000100884; ENSMUSG00000025404. [Q80TM6-2]
DR Ensembl; ENSMUST00000105250; ENSMUSP00000100885; ENSMUSG00000025404. [Q80TM6-3]
DR Ensembl; ENSMUST00000105251; ENSMUSP00000100886; ENSMUSG00000025404. [Q80TM6-3]
DR Ensembl; ENSMUST00000166820; ENSMUSP00000126608; ENSMUSG00000025404. [Q80TM6-1]
DR GeneID; 71750; -.
DR KEGG; mmu:71750; -.
DR UCSC; uc007hjl.2; mouse. [Q80TM6-1]
DR UCSC; uc007hjm.2; mouse. [Q80TM6-4]
DR UCSC; uc007hjo.2; mouse. [Q80TM6-3]
DR UCSC; uc007hjp.2; mouse. [Q80TM6-2]
DR CTD; 22864; -.
DR MGI; MGI:1919000; R3hdm2.
DR VEuPathDB; HostDB:ENSMUSG00000025404; -.
DR eggNOG; KOG2953; Eukaryota.
DR GeneTree; ENSGT00940000155609; -.
DR HOGENOM; CLU_007817_0_0_1; -.
DR InParanoid; Q80TM6; -.
DR OMA; KRRQIFX; -.
DR OrthoDB; 137913at2759; -.
DR PhylomeDB; Q80TM6; -.
DR BioGRID-ORCS; 71750; 0 hits in 28 CRISPR screens.
DR ChiTaRS; R3hdm2; mouse.
DR PRO; PR:Q80TM6; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q80TM6; protein.
DR Bgee; ENSMUSG00000025404; Expressed in animal zygote and 223 other tissues.
DR ExpressionAtlas; Q80TM6; baseline and differential.
DR Genevisible; Q80TM6; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.1370.50; -; 1.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR024771; SUZ.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF12752; SUZ; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51673; SUZ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1044
FT /note="R3H domain-containing protein 2"
FT /id="PRO_0000050788"
FT DOMAIN 169..232
FT /note="R3H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT DOMAIN 233..303
FT /note="SUZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01009"
FT REGION 23..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2K5"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 362
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2K5"
FT MOD_RES 365
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 381
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2K5"
FT MOD_RES 921
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2K5"
FT MOD_RES 923
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2K5"
FT MOD_RES 924
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 928
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 271..302
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010555"
FT VAR_SEQ 313..330
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010553"
FT VAR_SEQ 469..502
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010554"
FT VAR_SEQ 490..502
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010556"
FT CONFLICT 28
FT /note="K -> R (in Ref. 2; AK043545)"
FT /evidence="ECO:0000305"
FT CONFLICT 964
FT /note="K -> T (in Ref. 2; AK043545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1015
FT /note="L -> I (in Ref. 2; AK043545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1029
FT /note="A -> D (in Ref. 2; AK043545)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1044 AA; 114583 MW; 529D97E3E3EBEFBE CRC64;
MSNSNTTQET LEIMKESEKK LVEESVNKNK FISKTPSKED VEKEGEENGL RQETQRRTSS
HGHARKRAKS NSKLKLVRSL AVCEESSTPF VDGPLDTQDI IQLHISCPSD KEEEKSTKDV
SEKEDKDKSK EKVPRKMLSR DSSQEYTDST GIDLHEFLVN TLKKNPRDRM MLLKLEQEIL
DFINDNNNQF KKFPQMTSYH RMLLHRVAAY FGMDHNVDQT GKAVIINKTS STRIPEQRFS
EHIKDEKNTE FQQRFILKRD DASMDRDDNQ MRVPLQDGRR SKSIEEREEE YQRVRERIFA
RETGQNGYLN DIRLSKEAFS SSSHKRRQIF RGNREGLSRT SSSRQSSTDS ELKSLEPRPW
SSTDSDGSVR SMRPPVTKAS SFSGISILTR GDSIGSSKGG SAGRLSRPGM ALGAPEVCNQ
VTSPQSVRGL LPCTAQQQQQ QQQQQQQLPA LPPTPQHQPP LNNHMISQPV PALQPSPQPV
QFSPSSCPQV LLPVSPPQQY NMAEDLSNPF GQMSLSRQGS TEAADPSSAL FQPPLISQHP
QQASFIMASA GQPLPTSNYS TSSHAPPTQQ VLPPQGYMQP PQQIQVSYYP PGQYPNSNQQ
YRPLSHPVAY SPQRGQQLPQ ASQQPGLQPM MSNQQQTAYQ GMLGVQQPQN QGLLSNQRSS
MGGQMQGLVV QYTPLPSYQV PVGSDSQNVV QPSFQQPMLV PASQSVQGGL PTGGVPVYYS
MIPPAQQNGT SPSVGFLQPP GSEQYQMPQS PSPCSPPQMS QQYSGVSPSG PGVVVMQLNV
PNGPQAPQNP SMVQWSHCKY YSVEQRGQKP GDLYSPDGSP QANAQMGSSP VTSPTQSPAP
SPVTSLSNVC TGLSPLPVLT PFPRPGGPAQ GDGRYSLLGQ PLQYNLSICP PLLHGQSTYT
VHQGQSGLKH GNRGKRQALK SASTDLGTAD VVLGRVLEVT DLPEGITRTE ADKLFTQLAM
SGAKIQWLKD AQGLPGAGGG DNSGTAENGR HPDLAALYTI VAVFPSPLAA QNASLRLNNS
VSRFKLRVAK KNYDLRILER ASSQ
