ID   R3HD4_HUMAN             Reviewed;         268 AA.
AC   Q96D70;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=R3H domain-containing protein 4;
GN   Name=R3HDM4; Synonyms=C19orf22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC012775; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS12048.1; -.
DR   RefSeq; NP_620129.2; NM_138774.3.
DR   AlphaFoldDB; Q96D70; -.
DR   BioGRID; 124813; 4.
DR   IntAct; Q96D70; 4.
DR   STRING; 9606.ENSP00000355385; -.
DR   iPTMnet; Q96D70; -.
DR   PhosphoSitePlus; Q96D70; -.
DR   BioMuta; R3HDM4; -.
DR   DMDM; 74731421; -.
DR   EPD; Q96D70; -.
DR   jPOST; Q96D70; -.
DR   MassIVE; Q96D70; -.
DR   MaxQB; Q96D70; -.
DR   PaxDb; Q96D70; -.
DR   PeptideAtlas; Q96D70; -.
DR   PRIDE; Q96D70; -.
DR   ProteomicsDB; 76255; -.
DR   Antibodypedia; 53521; 40 antibodies from 12 providers.
DR   DNASU; 91300; -.
DR   Ensembl; ENST00000361574.10; ENSP00000355385.4; ENSG00000198858.10.
DR   GeneID; 91300; -.
DR   KEGG; hsa:91300; -.
DR   MANE-Select; ENST00000361574.10; ENSP00000355385.4; NM_138774.4; NP_620129.2.
DR   UCSC; uc002lqg.3; human.
DR   CTD; 91300; -.
DR   DisGeNET; 91300; -.
DR   GeneCards; R3HDM4; -.
DR   HGNC; HGNC:28270; R3HDM4.
DR   HPA; ENSG00000198858; Low tissue specificity.
DR   neXtProt; NX_Q96D70; -.
DR   OpenTargets; ENSG00000198858; -.
DR   PharmGKB; PA134902004; -.
DR   VEuPathDB; HostDB:ENSG00000198858; -.
DR   eggNOG; KOG1478; Eukaryota.
DR   GeneTree; ENSGT00390000015467; -.
DR   InParanoid; Q96D70; -.
DR   OMA; PLEFMAV; -.
DR   OrthoDB; 1173983at2759; -.
DR   PhylomeDB; Q96D70; -.
DR   TreeFam; TF331754; -.
DR   PathwayCommons; Q96D70; -.
DR   SignaLink; Q96D70; -.
DR   BioGRID-ORCS; 91300; 11 hits in 1081 CRISPR screens.
DR   ChiTaRS; R3HDM4; human.
DR   GenomeRNAi; 91300; -.
DR   Pharos; Q96D70; Tdark.
DR   PRO; PR:Q96D70; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96D70; protein.
DR   Bgee; ENSG00000198858; Expressed in blood and 200 other tissues.
DR   ExpressionAtlas; Q96D70; baseline and differential.
DR   Genevisible; Q96D70; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   InterPro; IPR025952; R3H-assoc_dom.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR039629; R3HDM4.
DR   PANTHER; PTHR32019; PTHR32019; 1.
DR   Pfam; PF01424; R3H; 1.
DR   Pfam; PF13902; R3H-assoc; 1.
DR   SUPFAM; SSF82708; SSF82708; 1.
DR   PROSITE; PS51061; R3H; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..268
FT                   /note="R3H domain-containing protein 4"
FT                   /id="PRO_0000281431"
FT   DOMAIN          187..250
FT                   /note="R3H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30350 MW;  3F30748230911130 CRC64;
     MVALENPECG PEAAEGTPGG RRLLPLPSCL PALASSQVKR LSASRRKQHF INQAVRNSDL
     VPKAKGRKSL QRLENTQYLL TLLETDGGLP GLEDGDLAPP ASPGIFAEAC NNATYVEVWN
     DFMNRSGEEQ ERVLRYLEDE GRSKARRRGP GRGEDRRRED PAYTPRECFQ RISRRLRAVL
     KRSRIPMETL ETWEERLLRF FSVSPQAVYT AMLDNSFERL LLHAVCQYMD LISASADLEG
     KRQMKVSNRH LDFLPPGLLL SAYLEQHS