R3HD4_MOUSE
ID R3HD4_MOUSE Reviewed; 262 AA.
AC Q4VBF2; Q8BJN1; Q8CGD7; Q8JZZ8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=R3H domain-containing protein 4;
GN Name=R3hdm4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, Czech II, and FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34653.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH40686.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK081288; BAC38183.1; -; mRNA.
DR EMBL; AK165610; BAE38292.1; -; mRNA.
DR EMBL; BC034653; AAH34653.1; ALT_INIT; mRNA.
DR EMBL; BC040686; AAH40686.1; ALT_INIT; mRNA.
DR EMBL; BC095970; AAH95970.1; -; mRNA.
DR EMBL; BC132463; AAI32464.1; -; mRNA.
DR CCDS; CCDS23997.1; -.
DR RefSeq; NP_818775.2; NM_177994.4.
DR AlphaFoldDB; Q4VBF2; -.
DR SMR; Q4VBF2; -.
DR BioGRID; 224634; 1.
DR STRING; 10090.ENSMUSP00000044570; -.
DR PhosphoSitePlus; Q4VBF2; -.
DR EPD; Q4VBF2; -.
DR MaxQB; Q4VBF2; -.
DR PaxDb; Q4VBF2; -.
DR PRIDE; Q4VBF2; -.
DR ProteomicsDB; 300283; -.
DR Antibodypedia; 53521; 40 antibodies from 12 providers.
DR Ensembl; ENSMUST00000045628; ENSMUSP00000044570; ENSMUSG00000035781.
DR Ensembl; ENSMUST00000171416; ENSMUSP00000132266; ENSMUSG00000035781.
DR GeneID; 109284; -.
DR KEGG; mmu:109284; -.
DR UCSC; uc007gan.1; mouse.
DR CTD; 91300; -.
DR MGI; MGI:1924814; R3hdm4.
DR VEuPathDB; HostDB:ENSMUSG00000035781; -.
DR eggNOG; KOG1478; Eukaryota.
DR GeneTree; ENSGT00390000015467; -.
DR HOGENOM; CLU_081608_0_0_1; -.
DR InParanoid; Q4VBF2; -.
DR OMA; PLEFMAV; -.
DR OrthoDB; 1173983at2759; -.
DR PhylomeDB; Q4VBF2; -.
DR TreeFam; TF331754; -.
DR BioGRID-ORCS; 109284; 3 hits in 72 CRISPR screens.
DR ChiTaRS; R3hdm4; mouse.
DR PRO; PR:Q4VBF2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q4VBF2; protein.
DR Bgee; ENSMUSG00000035781; Expressed in granulocyte and 216 other tissues.
DR ExpressionAtlas; Q4VBF2; baseline and differential.
DR Genevisible; Q4VBF2; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.1370.50; -; 1.
DR InterPro; IPR025952; R3H-assoc_dom.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR039629; R3HDM4.
DR PANTHER; PTHR32019; PTHR32019; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF13902; R3H-assoc; 1.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..262
FT /note="R3H domain-containing protein 4"
FT /id="PRO_0000281432"
FT DOMAIN 182..245
FT /note="R3H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 8
FT /note="E -> K (in Ref. 1; BAC38183)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 29660 MW; 4B0ECE9689829E06 CRC64;
MVALDNSEGG PEATPSGETR LSLPGCLPPL SGSQVKRVSA SRRKQHFINQ AVRNSDLVPR
AKGRKSLQRL ENTQYLLTLL ETAGGPPGVE DGDLTPAAPG IFAEACSNAT YVEVWNDFMN
RSGEEQERVL RYLEDESQGK RRRGPGRGED RRREDPVFTP HECFRRISRR LRSVLKRSRI
PMETLESWEE RLLAFFSVSP QAVYTAMLDN SYERLLLHAV CQYMDLISAS ADLEGRRQMK
VSNRHLDFLP PELLLSAYLD QQ
