R51A2_HUMAN
ID R51A2_HUMAN Reviewed; 1159 AA.
AC Q09MP3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=RAD51-associated protein 2;
GN Name=RAD51AP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAD51, TISSUE SPECIFICITY, AND
RP MUTAGENESIS OF LEU-1134 AND 1143-LEU-HIS-1144.
RC TISSUE=Testis;
RX PubMed=16990250; DOI=10.1093/nar/gkl665;
RA Kovalenko O.V., Wiese C., Schild D.;
RT "RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a
RT conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.";
RL Nucleic Acids Res. 34:5081-5092(2006).
CC -!- SUBUNIT: Interacts with RAD51. {ECO:0000269|PubMed:16990250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in meiotic tissues. Highly
CC expressed in testis. {ECO:0000269|PubMed:16990250}.
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DR EMBL; DQ860102; ABI64147.1; -; mRNA.
DR CCDS; CCDS42656.1; -.
DR RefSeq; NP_001092688.1; NM_001099218.2.
DR AlphaFoldDB; Q09MP3; -.
DR BioGRID; 609874; 3.
DR IntAct; Q09MP3; 1.
DR STRING; 9606.ENSP00000382030; -.
DR iPTMnet; Q09MP3; -.
DR PhosphoSitePlus; Q09MP3; -.
DR BioMuta; RAD51AP2; -.
DR DMDM; 121940162; -.
DR EPD; Q09MP3; -.
DR MassIVE; Q09MP3; -.
DR PaxDb; Q09MP3; -.
DR PeptideAtlas; Q09MP3; -.
DR PRIDE; Q09MP3; -.
DR ProteomicsDB; 58732; -.
DR Antibodypedia; 64463; 5 antibodies from 1 providers.
DR DNASU; 729475; -.
DR Ensembl; ENST00000399080.3; ENSP00000382030.2; ENSG00000214842.6.
DR GeneID; 729475; -.
DR KEGG; hsa:729475; -.
DR MANE-Select; ENST00000399080.3; ENSP00000382030.2; NM_001099218.3; NP_001092688.1.
DR UCSC; uc002rcl.2; human.
DR CTD; 729475; -.
DR GeneCards; RAD51AP2; -.
DR HGNC; HGNC:34417; RAD51AP2.
DR HPA; ENSG00000214842; Tissue enriched (testis).
DR neXtProt; NX_Q09MP3; -.
DR OpenTargets; ENSG00000214842; -.
DR PharmGKB; PA164725260; -.
DR VEuPathDB; HostDB:ENSG00000214842; -.
DR eggNOG; ENOG502RZS1; Eukaryota.
DR GeneTree; ENSGT00470000042500; -.
DR HOGENOM; CLU_282233_0_0_1; -.
DR InParanoid; Q09MP3; -.
DR OMA; WSQNRPD; -.
DR OrthoDB; 105986at2759; -.
DR PhylomeDB; Q09MP3; -.
DR PathwayCommons; Q09MP3; -.
DR SignaLink; Q09MP3; -.
DR BioGRID-ORCS; 729475; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; RAD51AP2; human.
DR GenomeRNAi; 729475; -.
DR Pharos; Q09MP3; Tdark.
DR PRO; PR:Q09MP3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q09MP3; protein.
DR Bgee; ENSG00000214842; Expressed in right testis and 43 other tissues.
DR GO; GO:0032991; C:protein-containing complex; IMP:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0036297; P:interstrand cross-link repair; IBA:GO_Central.
DR InterPro; IPR031419; RAD51_interact.
DR Pfam; PF15696; RAD51_interact; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..1159
FT /note="RAD51-associated protein 2"
FT /id="PRO_0000336071"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1159
FT /note="Interaction with RAD51"
FT /evidence="ECO:0000269|PubMed:16990250"
FT VARIANT 876
FT /note="V -> L (in dbSNP:rs17380212)"
FT /id="VAR_043478"
FT VARIANT 976
FT /note="R -> H (in dbSNP:rs17314548)"
FT /id="VAR_043479"
FT VARIANT 1037
FT /note="G -> D (in dbSNP:rs834514)"
FT /id="VAR_043480"
FT MUTAGEN 1134
FT /note="L->A: Strongly decreases interaction with RAD51;
FT when associated with 1143-AA-1144."
FT /evidence="ECO:0000269|PubMed:16990250"
FT MUTAGEN 1143..1144
FT /note="LH->AA: Strongly decreases interaction with RAD51;
FT when associated with A-1134."
FT /evidence="ECO:0000269|PubMed:16990250"
SQ SEQUENCE 1159 AA; 133907 MW; 4AAD0710B86E5562 CRC64;
MSLPQPTPRM AELRKPTSSL TPPEDPDSQP PSSKRLCLEE PGGVFKAGWR LPLVPRLSEA
EKVWELSPRP FKGLLVSTNA IFDNSTDSCV EKSVSGKQIC NLKCSNLKFQ MSSCLQSPPS
QSPDSDLRAS GRSEAGLHDR EAFSVHRSNS SKAGVSQLLP STSIHDIHGI RNENRKQQFV
QGRDNVHKEN PFLDVTFYKE TKSPFHEIKN RCKANSVVPS NKRENNISSS VLKISKSQNQ
PSLEIAKPSY FRDSGTISVP QFPMDLNSKM SSVYLKEIAK KKNDKKEAYV RDFTNIYWSQ
NRPDVKKQKL QNDKKTVEAE NIFSKCYEND YPSLSSQNTC KRKDLISSNY CNCSSIQCNV
RDSRKNFAIL ENANWEEAEC LDSYVLTRLE KSQNWDCNVR HILRRNRGNC WIINNCKTKC
ENMKKTEEKW NWLLLLEIDL LSKEDYHCAK VINAYEEQSK LLVREILGSQ TALITTVWLN
GKGENDNTLQ LRYNTTQKVF HVNNPFESFI IEIFYFHKSI SGNKKDNSIL TCCNILKCKK
QIGIIGIQNL ITRNMNTNIK NGILSIYLQD SVSEPLDILL KTNIAFLLNN FDSLTRIEND
FELEEECIFK CMLYLKYPKN IVENHTAYLV KILTSSRLLE DNMKPMLKKR KLFRTEQVFE
KSKKKLINSF SMTTQNTGFP IFETYEKIPL LMDFDDMDEI SLIREITCQN MSCPQQVVNV
ENWAHYNSST VKAHGNSCPQ FIQNNRGYIN ENFYEVNMHS QDLNMERKQG HNKISNFDCE
HIFEDLCNVR QQAIPASHNI IHNEETHTTS ITQVLNFWNL LSEIEEKKYD LILKEEVKVT
AESLTNSCQV HKDTKIEKEE KDSFFPMDDM FSVQSVSLIS KEVNVEENKY VNQNYVTNTN
EYESILPERE IANSKDFHRK NDSALYINHQ FETGLSEGND ECFQDLAAKY LSTEALTIVK
DFEMKRKFDL VLEELRMFHE ISRENELLST VETNNGQENY FGENDAEKVK MEIEKDLKMV
VVNKIRASSS FHDTIAGPNM GKSHQSLFKW KTVPNNGEQE VPNESCYPSR SEEELLYSTS
EKDCETPLPK RPAFLPDECK EEFNYLLRGG SHFPHGISRV RPLKTCSRPI RIGLSRKARI
KQLHPYLKQM CYGNLKENF
