ID   R7BPA_DANRE             Reviewed;         248 AA.
AC   Q08BU8; B0S6X3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Regulator of G-protein signaling 7-binding protein A;
DE   AltName: Full=R7 family-binding protein A;
GN   Name=rgs7bpa; ORFNames=si:dkey-250l23.3, zgc:154140;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling.
CC       Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling
CC       the subcellular location of the R7-Gbeta5 complexes. When
CC       palmitoylated, it targets the R7-Gbeta5 complexes to the plasma
CC       membrane, leading to inhibit G protein alpha subunits. When it is
CC       unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic
CC       shuttling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC   -!- PTM: Palmitoylated. Undergoes rapid palmitoylation turnover.
CC       Palmitoylation regulates the cell membrane and nuclear shuttling and
CC       the regulation of GPCR signaling. Upon depalmitoylation, it is targeted
CC       from the plasma membrane into the nucleus. GPCR signaling inhibits
CC       depalmitoylation and promotes localization to the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SIMILARITY: Belongs to the RGS7BP/RGS9BP family. {ECO:0000305}.
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DR   EMBL; BX571721; CAQ14270.1; -; Genomic_DNA.
DR   EMBL; BC124550; AAI24551.1; -; mRNA.
DR   RefSeq; NP_001070076.1; NM_001076608.1.
DR   AlphaFoldDB; Q08BU8; -.
DR   SMR; Q08BU8; -.
DR   STRING; 7955.ENSDARP00000080008; -.
DR   PaxDb; Q08BU8; -.
DR   Ensembl; ENSDART00000085573; ENSDARP00000080008; ENSDARG00000060601.
DR   GeneID; 767669; -.
DR   KEGG; dre:767669; -.
DR   CTD; 767669; -.
DR   ZFIN; ZDB-GENE-060929-380; rgs7bpa.
DR   eggNOG; ENOG502QPUF; Eukaryota.
DR   GeneTree; ENSGT00940000153725; -.
DR   HOGENOM; CLU_112711_0_0_1; -.
DR   InParanoid; Q08BU8; -.
DR   OMA; MRDMKNL; -.
DR   OrthoDB; 1068921at2759; -.
DR   PhylomeDB; Q08BU8; -.
DR   TreeFam; TF330985; -.
DR   PRO; PR:Q08BU8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000060601; Expressed in brain and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR026512; RGS7BP/RGS9BP.
DR   PANTHER; PTHR21029; PTHR21029; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Lipoprotein; Membrane; Nucleus; Palmitate;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..248
FT                   /note="Regulator of G-protein signaling 7-binding protein
FT                   A"
FT                   /id="PRO_0000287598"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           243
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           244
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        40
FT                   /note="L -> R (in Ref. 2; AAI24551)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   248 AA;  27877 MW;  BC685EECB08AA667 CRC64;
     MSSAPNGRKN RPRTAGTIFQ IGGKAPSRES ERRESSEALL AVSDCRMVVQ EFNTLVALYR
     ELVISIGEIS ADCPSLRAEM HKTRTKGCEM ARTAHQNLSA ISGPEDGEIH PEICRLFIQL
     QCCLEMYLTE MLKSVCLLGS LQLHRKGKHY LGATKLDSRK EDSSDIPILE DTSSTPPDCP
     HTYFLVATDI ENIERDMTEM KNLLSKLRET MPLPLKNQDD SSLLNLAPYP MVRQRKRRFF
     GLCCLVSS