ID   R7BPB_DANRE             Reviewed;         251 AA.
AC   Q4V9P3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Regulator of G-protein signaling 7-binding protein B;
DE   AltName: Full=R7 family-binding protein B;
GN   Name=rgs7bpb; ORFNames=wu:fj83a05, zgc:110002;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larval eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling.
CC       Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling
CC       the subcellular location of the R7-Gbeta5 complexes. When
CC       palmitoylated, it targets the R7-Gbeta5 complexes to the plasma
CC       membrane, leading to inhibit G protein alpha subunits. When it is
CC       unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic
CC       shuttling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC   -!- PTM: Palmitoylated. Undergoes rapid palmitoylation turnover.
CC       Palmitoylation regulates the cell membrane and nuclear shuttling and
CC       the regulation of GPCR signaling. Upon depalmitoylation, it is targeted
CC       from the plasma membrane into the nucleus. GPCR signaling inhibits
CC       depalmitoylation and promotes localization to the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SIMILARITY: Belongs to the RGS7BP/RGS9BP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC096790; AAH96790.1; -; mRNA.
DR   RefSeq; NP_001025240.1; NM_001030069.1.
DR   AlphaFoldDB; Q4V9P3; -.
DR   SMR; Q4V9P3; -.
DR   PaxDb; Q4V9P3; -.
DR   GeneID; 337556; -.
DR   KEGG; dre:337556; -.
DR   CTD; 337556; -.
DR   ZFIN; ZDB-GENE-030131-9502; rgs7bpb.
DR   eggNOG; ENOG502SKZ4; Eukaryota.
DR   InParanoid; Q4V9P3; -.
DR   OrthoDB; 1068921at2759; -.
DR   PhylomeDB; Q4V9P3; -.
DR   PRO; PR:Q4V9P3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR026512; RGS7BP/RGS9BP.
DR   PANTHER; PTHR21029; PTHR21029; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Lipoprotein; Membrane; Nucleus; Palmitate;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..251
FT                   /note="Regulator of G-protein signaling 7-binding protein
FT                   B"
FT                   /id="PRO_0000287599"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           246
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           247
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  28455 MW;  B9154C81BD10A750 CRC64;
     MCSAPNGRKN RPRSAANIFQ IGKSSVRDPE RRESTESARR AQRAMDDCRT TVQEFNTLVA
     LHREQVISIG ENTTDCPSLR AQMHKTRVKG CAVAQAAYQN LIAISGPEDG EIHPEICRLF
     IQLQCCLEMY ITEMLKSMCL LGVLQLHRKG NDMCPELNMD CRVDESSDVP MLEDRSSSPM
     DFPQDSWVVC ADIENIESDM REMRNLLSKL RETMPLPLKN QDDSSLLNLT PYPLVRQRKR
     RFSGLCCLVS G