ID   R7BP_BOVIN              Reviewed;         257 AA.
AC   Q08DH5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Regulator of G-protein signaling 7-binding protein;
DE   AltName: Full=R7 family-binding protein;
GN   Name=RGS7BP; Synonyms=R7BP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling.
CC       Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling
CC       the subcellular location of the R7-Gbeta5 complexes. When
CC       palmitoylated, it targets the R7-Gbeta5 complexes to the plasma
CC       membrane, leading to inhibit G protein alpha subunits. When it is
CC       unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic
CC       shuttling. May also act by controlling the proteolytic stability of R7
CC       proteins, probably by protecting them from degradation.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SUBUNIT: Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and
CC       RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein
CC       (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BQP9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8BQP9}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q8BQP9}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q8BQP9}. Note=Shuttling between the plasma
CC       membrane, the cytoplasm and the nucleus is regulated by palmitoylation.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- DOMAIN: The nuclear localization signal is both required for nuclear
CC       localization and palmitoylation. {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- PTM: Palmitoylated. Undergoes rapid palmitoylation turnover. De novo
CC       and turnover palmitoylation are both mediated by ZDHHC2. Palmitoylation
CC       regulates the cell membrane and nuclear shuttling and the regulation of
CC       GPCR signaling. Upon depalmitoylation, it is targeted from the plasma
CC       membrane into the nucleus. GPCR signaling inhibits depalmitoylation and
CC       promotes localization to the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SIMILARITY: Belongs to the RGS7BP/RGS9BP family. {ECO:0000305}.
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DR   EMBL; BC123745; AAI23746.1; -; mRNA.
DR   RefSeq; NP_001070398.1; NM_001076930.1.
DR   AlphaFoldDB; Q08DH5; -.
DR   SMR; Q08DH5; -.
DR   STRING; 9913.ENSBTAP00000006815; -.
DR   PaxDb; Q08DH5; -.
DR   Ensembl; ENSBTAT00000006815; ENSBTAP00000006815; ENSBTAG00000005169.
DR   GeneID; 613327; -.
DR   KEGG; bta:613327; -.
DR   CTD; 401190; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005169; -.
DR   VGNC; VGNC:33924; RGS7BP.
DR   eggNOG; ENOG502QPUF; Eukaryota.
DR   GeneTree; ENSGT00940000153725; -.
DR   HOGENOM; CLU_112711_0_0_1; -.
DR   InParanoid; Q08DH5; -.
DR   OMA; MRDMKNL; -.
DR   OrthoDB; 1068921at2759; -.
DR   TreeFam; TF330985; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000005169; Expressed in occipital lobe and 73 other tissues.
DR   ExpressionAtlas; Q08DH5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR026512; RGS7BP/RGS9BP.
DR   PANTHER; PTHR21029; PTHR21029; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Lipoprotein; Membrane; Nucleus; Palmitate;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..257
FT                   /note="Regulator of G-protein signaling 7-binding protein"
FT                   /id="PRO_0000287594"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           242..247
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   LIPID           252
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           253
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  29044 MW;  DCD8529763AD9BD1 CRC64;
     MSSAPNGRKK RPSRSTRSSI FQISKPPLQT GDWERRGSGS ESAHKSQRAL DDCKMLVQEF
     NTQVALYREL VISIGDVSVS CPSLREEMHK TRTKGCEMAR QAHQKLAAIS GPEDGEIHPE
     ICRLYIQLQC CLEMYTTEML KSICLLGSLQ FHRKGKEPGG GSKSLDCKIE ECAETPALED
     SSPSPVDIQQ HSWQVSTDIE NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPL
     VRRRKRRFFG LCCLVSS