ID   R7BP_XENLA              Reviewed;         254 AA.
AC   Q6GPM0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Regulator of G-protein signaling 7-binding protein;
DE   AltName: Full=R7 family-binding protein;
GN   Name=rgs7bp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling.
CC       Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling
CC       the subcellular location of the R7-Gbeta5 complexes. When
CC       palmitoylated, it targets the R7-Gbeta5 complexes to the plasma
CC       membrane, leading to inhibit G protein alpha subunits. When it is
CC       unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic
CC       shuttling. May also act by controlling the proteolytic stability of R7
CC       proteins, probably by protecting them from degradation.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SUBUNIT: Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and
CC       RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein
CC       (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BQP9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8BQP9}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q8BQP9}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- PTM: Palmitoylated. Undergoes rapid palmitoylation turnover.
CC       Palmitoylation regulates the cell membrane and nuclear shuttling and
CC       the regulation of GPCR signaling. Upon depalmitoylation, it is targeted
CC       from the plasma membrane into the nucleus. GPCR signaling inhibits
CC       depalmitoylation and promotes localization to the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q8BQP9}.
CC   -!- SIMILARITY: Belongs to the RGS7BP/RGS9BP family. {ECO:0000305}.
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DR   EMBL; BC073094; AAH73094.1; -; mRNA.
DR   RefSeq; NP_001085650.1; NM_001092181.1.
DR   AlphaFoldDB; Q6GPM0; -.
DR   SMR; Q6GPM0; -.
DR   GeneID; 444076; -.
DR   KEGG; xla:444076; -.
DR   CTD; 444076; -.
DR   Xenbase; XB-GENE-1001521; rgs7bp.S.
DR   OrthoDB; 1068921at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 444076; Expressed in internal ear and 10 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR026512; RGS7BP/RGS9BP.
DR   PANTHER; PTHR21029; PTHR21029; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Lipoprotein; Membrane; Nucleus; Palmitate;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..254
FT                   /note="Regulator of G-protein signaling 7-binding protein"
FT                   /id="PRO_0000287600"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           249
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           250
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   254 AA;  28909 MW;  59DDD431D15B4701 CRC64;
     MSSALNGRKN RPRDSQGSRF QISHKALPRD CERKGSADSA LTPQRTLEHC KMLVQDFNTQ
     VALFRELVIS IGDVSVNCPS LRAEMHKIRT KGCEMALHAH QKLSAISGPE DGEIHPEICR
     LYIQLQCCLE MYTTEMLKSM CLLGSLQHQQ KGKEPCVGPR IIDYKPEESS DIPILDDTSS
     SPTDMQQQCW QVSTDIENTE RDMREMKNLL SKLRETMPLP LKNQDDSSLL NLTPYPLVRR
     RKKRFFGLCC LISS