ID   R9BP_BOVIN              Reviewed;         237 AA.
AC   Q8MJG0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Regulator of G-protein signaling 9-binding protein;
DE   AltName: Full=RGS9-anchoring protein;
GN   Name=RGS9BP; Synonyms=R9AP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-226, PARTIAL PROTEIN SEQUENCE, TISSUE
RP   SPECIFICITY, AND INTERACTION WITH RGS9.
RC   TISSUE=Retina;
RX   PubMed=12119397; DOI=10.1073/pnas.152094799;
RA   Hu G., Wensel T.G.;
RT   "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein,
RT   RGS9-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9755-9760(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=12560335; DOI=10.1074/jbc.m212046200;
RA   Hu G., Zhang Z., Wensel T.G.;
RT   "Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP.";
RL   J. Biol. Chem. 278:14550-14554(2003).
CC   -!- FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling in
CC       phototransduction. Participates in the recovery phase of visual
CC       transduction via its interaction with RGS9-1 isoform. Acts as a
CC       membrane-anchor that mediates the targeting of RGS9-1 to the
CC       photoreceptor outer segment, where phototransduction takes place.
CC       Enhances the ability of RGS9-1 to stimulate G protein GTPase activity,
CC       allowing the visual signal to be terminated on the physiologically time
CC       scale. It also controls the proteolytic stability of RGS9-1, probably
CC       by protecting it from degradation (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:12560335}.
CC   -!- SUBUNIT: Specifically interacts with isoform RGS9-1 of RGS9. Component
CC       of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and
CC       RGS9BP. {ECO:0000269|PubMed:12119397}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in the retina. Only present
CC       in photoreceptors (at protein level). {ECO:0000269|PubMed:12119397}.
CC   -!- SIMILARITY: Belongs to the RGS7BP/RGS9BP family. {ECO:0000305}.
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DR   EMBL; AF480475; AAM67417.1; -; mRNA.
DR   RefSeq; NP_001159988.1; NM_001166516.1.
DR   RefSeq; XP_005218961.1; XM_005218904.3.
DR   AlphaFoldDB; Q8MJG0; -.
DR   SMR; Q8MJG0; -.
DR   CORUM; Q8MJG0; -.
DR   STRING; 9913.ENSBTAP00000048052; -.
DR   PaxDb; Q8MJG0; -.
DR   Ensembl; ENSBTAT00000051951; ENSBTAP00000048052; ENSBTAG00000039441.
DR   GeneID; 282338; -.
DR   KEGG; bta:282338; -.
DR   CTD; 388531; -.
DR   VEuPathDB; HostDB:ENSBTAG00000039441; -.
DR   VGNC; VGNC:33927; RGS9BP.
DR   eggNOG; ENOG502QT8D; Eukaryota.
DR   GeneTree; ENSGT00940000153725; -.
DR   HOGENOM; CLU_093021_0_0_1; -.
DR   InParanoid; Q8MJG0; -.
DR   OMA; MINEMEM; -.
DR   OrthoDB; 1602757at2759; -.
DR   TreeFam; TF331562; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000039441; Expressed in retina and 18 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0097381; C:photoreceptor disc membrane; TAS:Reactome.
DR   GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR026512; RGS7BP/RGS9BP.
DR   InterPro; IPR026513; RGS9BP.
DR   PANTHER; PTHR21029; PTHR21029; 1.
DR   PANTHER; PTHR21029:SF1; PTHR21029:SF1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Membrane; Reference proteome;
KW   Sensory transduction; Signal transduction inhibitor; Transmembrane;
KW   Transmembrane helix; Vision.
FT   CHAIN           1..237
FT                   /note="Regulator of G-protein signaling 9-binding protein"
FT                   /id="PRO_0000287585"
FT   TOPO_DOM        1..214
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..234
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          153..202
FT                   /note="SNARE-like"
FT                   /evidence="ECO:0000250"
FT   COILED          29..58
FT                   /evidence="ECO:0000255"
FT   COILED          144..169
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   237 AA;  25709 MW;  E726E3D2070BCB4C CRC64;
     MAKEECKALL DALNKATACY HHLVLTIGGS ADSQNLREEL QKTRQKAQEL AVAIRLRLTA
     PLRDRSLGAE ERAEFERLWV AFSGCLDLLE ADMRRALALS TEFPLQEPRR PLVRTGVEGG
     ATGVAARALS VRSLRHEAHR DFDVEDLHQL EREILQVGEM IQDMEMKVNV PRWTVQARQA
     AGAELLSSAS AGVSSVGGVS VEQRTGPCDL SKAKAATIFS AVLLAAVALA VCVAKLS