ID   R9BP_CHICK              Reviewed;         237 AA.
AC   Q6XK22;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Regulator of G-protein signaling 9-binding protein;
DE   AltName: Full=RGS9-anchor protein;
GN   Name=RGS9BP; Synonyms=R9AP;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Inner ear;
RX   PubMed=14664818; DOI=10.1016/s1044-7431(03)00231-8;
RA   Keresztes G., Mutai H., Hibino H., Hudspeth A.J., Heller S.;
RT   "Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken
RT   and mouse suggest multiple roles in the nervous system.";
RL   Mol. Cell. Neurosci. 24:687-695(2003).
CC   -!- FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling.
CC       Probably acts by regulating the activity of some 'R7' family protein
CC       (RGS6, RGS7, RGS9 and/or RGS11).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of neuronal tissues,
CC       particularly in sensory cells including inner ear hair cells,
CC       photoreceptors and dorsal root ganglion neurons.
CC       {ECO:0000269|PubMed:14664818}.
CC   -!- SIMILARITY: Belongs to the RGS7BP/RGS9BP family. {ECO:0000305}.
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DR   EMBL; AY229887; AAP55846.1; -; mRNA.
DR   RefSeq; NP_989836.1; NM_204505.1.
DR   AlphaFoldDB; Q6XK22; -.
DR   SMR; Q6XK22; -.
DR   STRING; 9031.ENSGALP00000007438; -.
DR   PaxDb; Q6XK22; -.
DR   Ensembl; ENSGALT00000007450; ENSGALP00000007438; ENSGALG00000004675.
DR   GeneID; 395170; -.
DR   KEGG; gga:395170; -.
DR   CTD; 388531; -.
DR   VEuPathDB; HostDB:geneid_395170; -.
DR   eggNOG; ENOG502QT8D; Eukaryota.
DR   GeneTree; ENSGT00940000153725; -.
DR   HOGENOM; CLU_093021_0_0_1; -.
DR   InParanoid; Q6XK22; -.
DR   OMA; VIFSTCM; -.
DR   OrthoDB; 1602757at2759; -.
DR   PhylomeDB; Q6XK22; -.
DR   TreeFam; TF331562; -.
DR   PRO; PR:Q6XK22; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000004675; Expressed in cerebellum and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR026512; RGS7BP/RGS9BP.
DR   InterPro; IPR026513; RGS9BP.
DR   PANTHER; PTHR21029; PTHR21029; 1.
DR   PANTHER; PTHR21029:SF1; PTHR21029:SF1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Reference proteome; Signal transduction inhibitor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..237
FT                   /note="Regulator of G-protein signaling 9-binding protein"
FT                   /id="PRO_0000287588"
FT   TOPO_DOM        1..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   COILED          29..58
FT                   /evidence="ECO:0000255"
FT   COILED          135..169
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   237 AA;  26317 MW;  51F53796CAE93CCB CRC64;
     MVKEECKALL DALSRVTACY RHMVLTIGGT SDSQNLREEL KKTRQKAQEL AVANRNKLTT
     VLRDKTVSKE DKAEFERLWV IFSTCLEILE IDMRRALELG HEFPLNVPKK HLIQTGMSGG
     TSGVAARAMS VQNMKYEAEH NIDVVDLKDL ENEINQVGEM MYEMEMKVNV PQWTVEAKQD
     PGAELKSTIS VGASSIGMIS VEENKSFCDI SKVLAGIIFS AVLIIAIVLA VCVVKLS