RA51D_ARATH
ID RA51D_ARATH Reviewed; 322 AA.
AC Q9LQQ2; Q5K4Q1;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=DNA repair protein RAD51 homolog 4;
DE Short=AtRAD51D;
GN Name=RAD51D; OrderedLocusNames=At1g07745; ORFNames=F24B9.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Siaud N.;
RT "A study of RAD51 homologues from Arabidopsis.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia; TISSUE=Flower bud;
RX PubMed=15952068; DOI=10.1007/s11103-005-2187-1;
RA Osakabe K., Abe K., Yamanouchi H., Takyuu T., Yoshioka T., Ito Y., Kato T.,
RA Tabata S., Kurei S., Yoshioka Y., Machida Y., Seki M., Kobayashi M.,
RA Shinozaki K., Ichikawa H., Toki S.;
RT "Arabidopsis Rad51B is important for double-strand DNA breaks repair in
RT somatic cells.";
RL Plant Mol. Biol. 57:819-833(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA breaks arising during DNA replication or induced
CC by DNA-damaging agents. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9LQQ2-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF75078.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ549434; CAD70703.1; -; mRNA.
DR EMBL; AB194811; BAD89165.1; -; mRNA.
DR EMBL; AC007583; AAF75078.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28173.1; -; Genomic_DNA.
DR PIR; H86212; H86212.
DR RefSeq; NP_172254.2; NM_100649.3. [Q9LQQ2-1]
DR AlphaFoldDB; Q9LQQ2; -.
DR SMR; Q9LQQ2; -.
DR STRING; 3702.AT1G07745.1; -.
DR PaxDb; Q9LQQ2; -.
DR PRIDE; Q9LQQ2; -.
DR EnsemblPlants; AT1G07745.1; AT1G07745.1; AT1G07745. [Q9LQQ2-1]
DR GeneID; 837289; -.
DR Gramene; AT1G07745.1; AT1G07745.1; AT1G07745. [Q9LQQ2-1]
DR KEGG; ath:AT1G07745; -.
DR Araport; AT1G07745; -.
DR TAIR; locus:2825233; AT1G07745.
DR eggNOG; KOG1433; Eukaryota.
DR HOGENOM; CLU_058452_1_0_1; -.
DR InParanoid; Q9LQQ2; -.
DR OMA; QRIHTFR; -.
DR PhylomeDB; Q9LQQ2; -.
DR PRO; PR:Q9LQQ2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQQ2; baseline and differential.
DR Genevisible; Q9LQQ2; AT.
DR GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; IBA:GO_Central.
DR GO; GO:0005657; C:replication fork; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IMP:TAIR.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:1900426; P:positive regulation of defense response to bacterium; IMP:TAIR.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR GO; GO:0016444; P:somatic cell DNA recombination; IMP:TAIR.
DR GO; GO:0042148; P:strand invasion; IBA:GO_Central.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR Pfam; PF08423; Rad51; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; DNA damage; DNA recombination;
KW DNA repair; DNA-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..322
FT /note="DNA repair protein RAD51 homolog 4"
FT /id="PRO_0000122946"
FT BINDING 114..121
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 35384 MW; A4B522F24CC4BF14 CRC64;
MAPLKHLEKE NPIIDACFQD FCASHGILTI EDFLLHDLYE LTAFSQRQTN ADRLKEGITL
ILSLIERQCR PLVNGLKLLE DLHRNKHTLS TGDKETDSLL QGGFREGQLT ELVGPSSSGK
TQFCMQAAAS VAENHLGRVL YLDTGNSFSA RRIAQFICSS SDATLGQKVM SRILCHTVYD
IYTLFDTLQD LEITLRLQMN VNESRLRLLV VDSISSLITP ILGGSGSQGR ALMVAIGYLL
KKLAHEHSIA ILVTNHTVGA GGEGGKTKPA LGETWKSIPH VRLSLSRDHK NSNCTISILK
HTSLPSGQAA KTLTRKENQQ CP
