RA51D_DICDI
ID RA51D_DICDI Reviewed; 354 AA.
AC Q1ZXF0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Probable DNA repair protein RAD51 homolog 4;
GN Name=rad51d; ORFNames=DDB_G0285287;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA breaks arising during DNA replication or induced
CC by DNA-damaging agents. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000077; EAS66855.1; -; Genomic_DNA.
DR RefSeq; XP_001134538.1; XM_001134538.1.
DR AlphaFoldDB; Q1ZXF0; -.
DR SMR; Q1ZXF0; -.
DR STRING; 44689.DDB0232317; -.
DR PaxDb; Q1ZXF0; -.
DR EnsemblProtists; EAS66855; EAS66855; DDB_G0285287.
DR GeneID; 8625032; -.
DR KEGG; ddi:DDB_G0285287; -.
DR dictyBase; DDB_G0285287; -.
DR eggNOG; KOG1433; Eukaryota.
DR HOGENOM; CLU_783966_0_0_1; -.
DR InParanoid; Q1ZXF0; -.
DR OMA; ILISIDW; -.
DR PhylomeDB; Q1ZXF0; -.
DR PRO; PR:Q1ZXF0; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; IBA:GO_Central.
DR GO; GO:0005657; C:replication fork; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; ISS:dictyBase.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; ISS:dictyBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR GO; GO:0042148; P:strand invasion; IBA:GO_Central.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR Pfam; PF08423; Rad51; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..354
FT /note="Probable DNA repair protein RAD51 homolog 4"
FT /id="PRO_0000327777"
FT BINDING 115..122
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 354 AA; 40822 MW; AF2143B0A140AE6A CRC64;
MEEESISGLE VRFYQTQCLS EDNVIKFENN GYPMIDLILF SDAYQIQRNT SIPIETVTLI
QRNLQRLFSS VPINGYQHYL DVKEFKTHYS SGIKLLDQLL GGNGFTSGEI YELVGNTSCG
KTQISMCCSL NLSQQYNSNI IYIDSSNSFS PPRLIEIFKS NYLIKQRQKQ QQKQQQKQHQ
KQQENNDKIE QDKILKILDR IKVFNCFDSI TLLELLSTID STLSIISDEI PTFENQFYKG
LKMVVIDSIG TLLAPIIGGK QTQGHYTMMM ISRLIKYIAD TYQIIFLITN NTVGGNSFDN
KAALGEAWSM VPNHQLMINH QYNDDENEER SIYIEKSTRL PVSIIFIINL YWLF
