ID   RAB15_BOVIN             Reviewed;         212 AA.
AC   Q1RMR4;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Ras-related protein Rab-15;
GN   Name=RAB15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act in concert with RAB3A in regulating aspects of
CC       synaptic vesicle membrane flow within the nerve terminal. EHBP1L1.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The GTP bound form of RAB15 interacts with REP15. Interacts
CC       (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC114760; AAI14761.1; -; mRNA.
DR   RefSeq; NP_001040003.1; NM_001046538.1.
DR   AlphaFoldDB; Q1RMR4; -.
DR   SMR; Q1RMR4; -.
DR   STRING; 9913.ENSBTAP00000035638; -.
DR   PaxDb; Q1RMR4; -.
DR   PRIDE; Q1RMR4; -.
DR   Ensembl; ENSBTAT00000035769; ENSBTAP00000035638; ENSBTAG00000003474.
DR   GeneID; 614507; -.
DR   KEGG; bta:614507; -.
DR   CTD; 376267; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003474; -.
DR   VGNC; VGNC:33623; RAB15.
DR   eggNOG; KOG0078; Eukaryota.
DR   GeneTree; ENSGT00940000157848; -.
DR   HOGENOM; CLU_041217_23_1_1; -.
DR   InParanoid; Q1RMR4; -.
DR   OMA; ACTNFNI; -.
DR   OrthoDB; 1149105at2759; -.
DR   TreeFam; TF314097; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000003474; Expressed in corpus epididymis and 96 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0032593; C:insulin-responsive compartment; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IBA:GO_Central.
DR   GO; GO:1903307; P:positive regulation of regulated secretory pathway; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR   GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   CDD; cd04117; Rab15; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041826; Rab15.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..212
FT                   /note="Ras-related protein Rab-15"
FT                   /id="PRO_0000253741"
FT   REGION          192..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         15..22
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         63..67
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         121..124
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         212
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           210
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           212
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   212 AA;  24425 MW;  36BC652FF3B3CF04 CRC64;
     MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ
     IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG
     NKADEEQKRQ VGREQGQQLA REYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELEGL
     RTRANHELAL AELEEDEGKP EGPANSSKTC WC