RAB15_RAT
ID RAB15_RAT Reviewed; 212 AA.
AC P35289; Q504L6;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Ras-related protein Rab-15;
GN Name=Rab15;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=1313420; DOI=10.1016/s0021-9258(18)42619-1;
RA Elferink L.A., Anzai K., Scheller R.H.;
RT "Rab15, a novel low molecular weight GTP-binding protein specifically
RT expressed in rat brain.";
RL J. Biol. Chem. 267:5768-5775(1992).
RN [2]
RP ERRATUM OF PUBMED:1313420.
RX PubMed=1429617; DOI=10.1016/s0021-9258(18)41727-9;
RA Elferink L.A., Anzai K., Scheller R.H.;
RL J. Biol. Chem. 267:22693-22693(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act in concert with RAB3A in regulating aspects of
CC synaptic vesicle membrane flow within the nerve terminal.
CC -!- SUBUNIT: The GTP bound form of RAB15 interacts with REP15. Interacts
CC (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in neural tissues.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; M83679; AAA41995.1; -; mRNA.
DR EMBL; BC094954; AAH94954.1; -; mRNA.
DR PIR; F42148; F42148.
DR RefSeq; NP_942044.1; NM_198749.2.
DR AlphaFoldDB; P35289; -.
DR SMR; P35289; -.
DR BioGRID; 256132; 1.
DR STRING; 10116.ENSRNOP00000010043; -.
DR iPTMnet; P35289; -.
DR PhosphoSitePlus; P35289; -.
DR jPOST; P35289; -.
DR PaxDb; P35289; -.
DR PRIDE; P35289; -.
DR Ensembl; ENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
DR GeneID; 299156; -.
DR KEGG; rno:299156; -.
DR UCSC; RGD:735172; rat.
DR CTD; 376267; -.
DR RGD; 735172; Rab15.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000157848; -.
DR HOGENOM; CLU_041217_23_1_1; -.
DR InParanoid; P35289; -.
DR OMA; ACTNFNI; -.
DR OrthoDB; 1149105at2759; -.
DR PhylomeDB; P35289; -.
DR TreeFam; TF314097; -.
DR Reactome; R-RNO-8873719; RAB geranylgeranylation.
DR PRO; PR:P35289; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000007364; Expressed in frontal cortex and 17 other tissues.
DR Genevisible; P35289; RN.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0032593; C:insulin-responsive compartment; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; TAS:RGD.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; TAS:RGD.
DR GO; GO:1903307; P:positive regulation of regulated secretory pathway; ISO:RGD.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR CDD; cd04117; Rab15; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041826; Rab15.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..212
FT /note="Ras-related protein Rab-15"
FT /id="PRO_0000121190"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 212
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 210
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 212
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 212 AA; 24283 MW; 04817DDA66CADE12 CRC64;
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ
IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG
NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELDGL
RTCASNELAL AELEEDEGKT EGPANSSKTC WC
