RAB18_CAEEL
ID RAB18_CAEEL Reviewed; 203 AA.
AC Q8MXS1; Q9BL22;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Ras-related protein Rab-18;
GN Name=rab-18; ORFNames=Y92C3B.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24843160; DOI=10.1073/pnas.1400696111;
RA Szumowski S.C., Botts M.R., Popovich J.J., Smelkinson M.G., Troemel E.R.;
RT "The small GTPase RAB-11 directs polarized exocytosis of the intracellular
RT pathogen N. parisii for fecal-oral transmission from C. elegans.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:8215-8220(2014).
CC -!- FUNCTION: Plays a role in apical endocytosis/recycling
CC (PubMed:24843160). May be implicated in transport between the plasma
CC membrane and early endosomes (By similarity). Plays a role in the
CC shedding of pathogen spores from intestinal cells (PubMed:24843160).
CC {ECO:0000250|UniProtKB:Q9NP72, ECO:0000269|PubMed:24843160}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=Q8MXS1-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q8MXS1-2; Sequence=VSP_020784, VSP_020785;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in disrupted
CC clearance of intracellular pathogen N.parisii from intestinal cells.
CC {ECO:0000269|PubMed:24843160}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080242; CCD62282.1; -; Genomic_DNA.
DR EMBL; FO080242; CCD62283.1; -; Genomic_DNA.
DR RefSeq; NP_741092.1; NM_171081.4. [Q8MXS1-1]
DR RefSeq; NP_741093.2; NM_171861.4. [Q8MXS1-2]
DR AlphaFoldDB; Q8MXS1; -.
DR SMR; Q8MXS1; -.
DR BioGRID; 40535; 2.
DR STRING; 6239.Y92C3B.3b; -.
DR EPD; Q8MXS1; -.
DR PaxDb; Q8MXS1; -.
DR PeptideAtlas; Q8MXS1; -.
DR PRIDE; Q8MXS1; -.
DR EnsemblMetazoa; Y92C3B.3a.1; Y92C3B.3a.1; WBGene00004277. [Q8MXS1-2]
DR EnsemblMetazoa; Y92C3B.3a.2; Y92C3B.3a.2; WBGene00004277. [Q8MXS1-2]
DR EnsemblMetazoa; Y92C3B.3b.1; Y92C3B.3b.1; WBGene00004277. [Q8MXS1-1]
DR EnsemblMetazoa; Y92C3B.3b.2; Y92C3B.3b.2; WBGene00004277. [Q8MXS1-1]
DR GeneID; 175272; -.
DR KEGG; cel:CELE_Y92C3B.3; -.
DR UCSC; Y92C3B.3b; c. elegans. [Q8MXS1-1]
DR CTD; 175272; -.
DR WormBase; Y92C3B.3a; CE34438; WBGene00004277; rab-18. [Q8MXS1-2]
DR WormBase; Y92C3B.3b; CE27340; WBGene00004277; rab-18. [Q8MXS1-1]
DR eggNOG; KOG0080; Eukaryota.
DR GeneTree; ENSGT00940000169006; -.
DR HOGENOM; CLU_041217_10_7_1; -.
DR InParanoid; Q8MXS1; -.
DR OMA; HRTLFIE; -.
DR OrthoDB; 1247169at2759; -.
DR PhylomeDB; Q8MXS1; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR Reactome; R-CEL-8873719; RAB geranylgeranylation.
DR Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q8MXS1; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004277; Expressed in embryo and 3 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0034389; P:lipid droplet organization; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 3: Inferred from homology;
KW Alternative splicing; GTP-binding; Lipoprotein; Methylation;
KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..203
FT /note="Ras-related protein Rab-18"
FT /id="PRO_0000121200"
FT MOTIF 40..48
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 18..25
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 203
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 201
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 203
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..27
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_020784"
FT VAR_SEQ 129
FT /note="M -> MVRKSRFCSIFGLKNNFQ (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_020785"
SQ SEQUENCE 203 AA; 22620 MW; 3A5C72AE8FA16761 CRC64;
MSDDSSSPLT TLKILIIGES GVGKSSLMLR FVDDVFDPEQ AATIGVDFRV TSMAIDGNRV
KLAIWDTAGQ ERFRTLTPSY YRGAQGVICV YDVTSRSSFE KLNHWMQEVD TYCTNDNIIK
MMVANKIDMP NRVVTREEGL KFAKRHRTLF IEASAKTKEG VQCTFEELIE KIIQTPDLWD
NDRPSFRLGQ PTGSSGGGGM CGC
