RAB18_CHICK
ID RAB18_CHICK Reviewed; 206 AA.
AC Q5ZLG1;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Ras-related protein Rab-18;
DE Flags: Precursor;
GN Name=RAB18; ORFNames=RCJMB04_6g4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for the localization of ZFYVE1 to lipid droplets and
CC for its function in mediating the formation of endoplasmic reticulum-
CC lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical
CC endocytosis/recycling (By similarity). Plays a key role in eye and
CC brain development and neurodegeneration (By similarity).
CC {ECO:0000250|UniProtKB:Q8MXS1, ECO:0000250|UniProtKB:Q9NP72}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:P35293}. Lipid droplet
CC {ECO:0000250|UniProtKB:Q9NP72}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AJ719773; CAG31432.1; -; mRNA.
DR RefSeq; NP_001006355.1; NM_001006355.1.
DR AlphaFoldDB; Q5ZLG1; -.
DR SMR; Q5ZLG1; -.
DR BioGRID; 681433; 1.
DR IntAct; Q5ZLG1; 1.
DR STRING; 9031.ENSGALP00000012019; -.
DR PaxDb; Q5ZLG1; -.
DR Ensembl; ENSGALT00000085826; ENSGALP00000062764; ENSGALG00000007435.
DR GeneID; 420483; -.
DR KEGG; gga:420483; -.
DR CTD; 22931; -.
DR VEuPathDB; HostDB:geneid_420483; -.
DR eggNOG; KOG0080; Eukaryota.
DR GeneTree; ENSGT00940000157325; -.
DR HOGENOM; CLU_041217_10_7_1; -.
DR InParanoid; Q5ZLG1; -.
DR OMA; HRTLFIE; -.
DR OrthoDB; 1247169at2759; -.
DR PhylomeDB; Q5ZLG1; -.
DR TreeFam; TF313448; -.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR Reactome; R-GGA-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR Reactome; R-GGA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR PRO; PR:Q5ZLG1; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000007435; Expressed in heart and 14 other tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; ISS:UniProtKB.
DR GO; GO:0019003; F:GDP binding; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:0001654; P:eye development; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0034389; P:lipid droplet organization; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; GTP-binding; Lipid droplet;
KW Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate;
KW Prenylation; Protein transport; Reference proteome; Transport.
FT CHAIN 1..203
FT /note="Ras-related protein Rab-18"
FT /id="PRO_0000121197"
FT PROPEP 204..206
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370765"
FT MOTIF 37..45
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 122..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 203
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 199
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 203
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 206 AA; 22954 MW; C312C672E72FDA22 CRC64;
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA
IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD NWLNELETYC TRNDIVKMLV
GNKIDKENRE VDRNEGLKFA RKHSMLFIEA SAKTCDGVQC AFEELVEKII QTPGLWESES
QNKGVKLSNK EEGHGGGACG GYCSML
