RAB19_HUMAN
ID RAB19_HUMAN Reviewed; 217 AA.
AC A4D1S5; A4D1S6; B2RTS6; B5MDR2; Q9UL27;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Ras-related protein Rab-19;
GN Name=RAB19; Synonyms=RAB19B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 29-71 (ISOFORM 1).
RC TISSUE=Colon carcinoma;
RA Opdam F.J.M., van Bokhoven H., Kamps G., Ginsel L.A., Fransen J.A.M.;
RT "Rab GTPases expressed in Caco-2 cells.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC A4D1S5; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-4401710, EBI-10171774;
CC A4D1S5; P83369: LSM11; NbExp=3; IntAct=EBI-4401710, EBI-2626024;
CC A4D1S5; P47224: RABIF; NbExp=5; IntAct=EBI-4401710, EBI-713992;
CC A4D1S5; Q86W61: VCAN; NbExp=3; IntAct=EBI-4401710, EBI-23901925;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A4D1S5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4D1S5-2; Sequence=VSP_036588;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AC069335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24028.1; -; Genomic_DNA.
DR EMBL; CH236950; EAL24029.1; -; Genomic_DNA.
DR EMBL; BC140796; AAI40797.1; -; mRNA.
DR EMBL; AF091033; AAF00046.1; -; mRNA.
DR CCDS; CCDS34762.2; -. [A4D1S5-1]
DR RefSeq; NP_001008749.2; NM_001008749.2. [A4D1S5-1]
DR RefSeq; XP_005250053.1; XM_005249996.3. [A4D1S5-1]
DR RefSeq; XP_016867696.1; XM_017012207.1. [A4D1S5-1]
DR AlphaFoldDB; A4D1S5; -.
DR SMR; A4D1S5; -.
DR BioGRID; 135075; 10.
DR IntAct; A4D1S5; 6.
DR STRING; 9606.ENSP00000440167; -.
DR iPTMnet; A4D1S5; -.
DR PhosphoSitePlus; A4D1S5; -.
DR BioMuta; RAB19; -.
DR EPD; A4D1S5; -.
DR jPOST; A4D1S5; -.
DR MassIVE; A4D1S5; -.
DR MaxQB; A4D1S5; -.
DR PaxDb; A4D1S5; -.
DR PeptideAtlas; A4D1S5; -.
DR PRIDE; A4D1S5; -.
DR ProteomicsDB; 629; -. [A4D1S5-1]
DR ProteomicsDB; 630; -. [A4D1S5-2]
DR Antibodypedia; 32445; 88 antibodies from 22 providers.
DR DNASU; 401409; -.
DR Ensembl; ENST00000356407.3; ENSP00000348778.3; ENSG00000146955.11. [A4D1S5-1]
DR Ensembl; ENST00000537763.6; ENSP00000440167.1; ENSG00000146955.11. [A4D1S5-1]
DR GeneID; 401409; -.
DR KEGG; hsa:401409; -.
DR MANE-Select; ENST00000537763.6; ENSP00000440167.1; NM_001008749.3; NP_001008749.2.
DR UCSC; uc010lni.2; human. [A4D1S5-1]
DR CTD; 401409; -.
DR GeneCards; RAB19; -.
DR HGNC; HGNC:19982; RAB19.
DR HPA; ENSG00000146955; Tissue enhanced (bone).
DR neXtProt; NX_A4D1S5; -.
DR OpenTargets; ENSG00000146955; -.
DR PharmGKB; PA162400617; -.
DR VEuPathDB; HostDB:ENSG00000146955; -.
DR eggNOG; KOG0084; Eukaryota.
DR GeneTree; ENSGT00940000156717; -.
DR HOGENOM; CLU_041217_23_1_1; -.
DR InParanoid; A4D1S5; -.
DR OMA; CVVQHFR; -.
DR OrthoDB; 1149105at2759; -.
DR PhylomeDB; A4D1S5; -.
DR TreeFam; TF300097; -.
DR PathwayCommons; A4D1S5; -.
DR Reactome; R-HSA-8873719; RAB geranylgeranylation.
DR SignaLink; A4D1S5; -.
DR BioGRID-ORCS; 401409; 9 hits in 1068 CRISPR screens.
DR ChiTaRS; RAB19; human.
DR GenomeRNAi; 401409; -.
DR Pharos; A4D1S5; Tbio.
DR PRO; PR:A4D1S5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A4D1S5; protein.
DR Bgee; ENSG00000146955; Expressed in mucosa of transverse colon and 55 other tissues.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; GTP-binding; Lipoprotein; Membrane;
KW Methylation; Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..217
FT /note="Ras-related protein Rab-19"
FT /id="PRO_0000300459"
FT MOTIF 46..54
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 72..76
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 130..133
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 217
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 215
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 217
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 67
FT /note="K -> KNSSASIITFASIQIHGQTQKMSPQIWTKSSHYLWEPLIWTLLPVLL
FT Q (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036588"
FT CONFLICT 31
FT /note="T -> S (in Ref. 4; AAF00046)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24400 MW; 787695528A6EE366 CRC64;
MHFSSSARAA DENFDYLFKI ILIGDSNVGK TCVVQHFKSG VYTETQQNTI GVDFTVRSLD
IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESIPH WIHEIEKYGA
ANVVIMLIGN KCDLWEKRHV LFEDACTLAE KYGLLAVLET SAKESKNIEE VFVLMAKELI
ARNSLHLYGE SALNGLPLDS SPVLMAQGPS EKTHCTC
