RAB19_MOUSE
ID RAB19_MOUSE Reviewed; 217 AA.
AC P35294; O35697; Q6GTV2;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 3.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Ras-related protein Rab-19;
GN Name=Rab19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=7721101; DOI=10.1016/0378-1119(94)00931-h;
RA Luetcke A., Olkkonen V.M., Dupree P., Lutcke H., Simons K., Zerial M.;
RT "Isolation of a murine cDNA clone encoding Rab19, a novel tissue-specific
RT small GTPase.";
RL Gene 155:257-260(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=16923123; DOI=10.1111/j.1365-2443.2006.00997.x;
RA Itoh T., Satoh M., Kanno E., Fukuda M.;
RT "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing
RT proteins based on their Rab-binding activity.";
RL Genes Cells 11:1023-1037(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.
RC TISSUE=Kidney;
RX PubMed=1555775; DOI=10.1016/0378-1119(92)90387-5;
RA Chavrier P., Simons K., Zerial M.;
RT "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed
RT by a PCR cloning approach.";
RL Gene 112:261-264(1992).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in a tissue-specific manner. Detected at
CC high levels in intestine, lung and spleen, and at a lower level in
CC kidney.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; X80473; CAA56644.1; -; mRNA.
DR EMBL; AB232613; BAF02875.1; -; mRNA.
DR EMBL; BC032936; AAH32936.1; -; mRNA.
DR EMBL; M79309; AAK14833.1; -; mRNA.
DR CCDS; CCDS20021.1; -.
DR PIR; JH0649; JH0649.
DR PIR; PC4012; PC4012.
DR RefSeq; NP_035356.1; NM_011226.1.
DR AlphaFoldDB; P35294; -.
DR SMR; P35294; -.
DR DIP; DIP-60515N; -.
DR IntAct; P35294; 24.
DR STRING; 10090.ENSMUSP00000031986; -.
DR iPTMnet; P35294; -.
DR PhosphoSitePlus; P35294; -.
DR EPD; P35294; -.
DR MaxQB; P35294; -.
DR PaxDb; P35294; -.
DR PeptideAtlas; P35294; -.
DR PRIDE; P35294; -.
DR ProteomicsDB; 253141; -.
DR Antibodypedia; 32445; 88 antibodies from 22 providers.
DR DNASU; 19331; -.
DR Ensembl; ENSMUST00000031986; ENSMUSP00000031986; ENSMUSG00000029923.
DR GeneID; 19331; -.
DR KEGG; mmu:19331; -.
DR UCSC; uc009blp.1; mouse.
DR CTD; 401409; -.
DR MGI; MGI:103292; Rab19.
DR VEuPathDB; HostDB:ENSMUSG00000029923; -.
DR eggNOG; KOG0084; Eukaryota.
DR GeneTree; ENSGT00940000156717; -.
DR HOGENOM; CLU_041217_23_1_1; -.
DR InParanoid; P35294; -.
DR OMA; CVVQHFR; -.
DR OrthoDB; 1149105at2759; -.
DR PhylomeDB; P35294; -.
DR TreeFam; TF300097; -.
DR Reactome; R-MMU-8873719; RAB geranylgeranylation.
DR BioGRID-ORCS; 19331; 2 hits in 70 CRISPR screens.
DR PRO; PR:P35294; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P35294; protein.
DR Bgee; ENSMUSG00000029923; Expressed in otolith organ and 66 other tissues.
DR Genevisible; P35294; MM.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..217
FT /note="Ras-related protein Rab-19"
FT /id="PRO_0000121201"
FT MOTIF 46..54
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 72..76
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 130..133
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 217
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 215
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 217
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 9
FT /note="T -> R (in Ref. 1; CAA56644)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24398 MW; BAC8008B72A10036 CRC64;
MQFSSSSRTS DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI GVDFTVRSLE
IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESVPH WIHEIEKYGA
ANLVIMLIGN KSDLWEKRHV LFEDACTLAE KHGLLAVLET SAKESRNIDE VFVLMAKELI
ARNSLHLYGE SAQQGLSQDS SPVLVAQVPN ESTRCTC
