ID   RAB19_RAT               Reviewed;         217 AA.
AC   Q5M7U5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Ras-related protein Rab-19;
GN   Name=Rab19;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC088443; AAH88443.1; -; mRNA.
DR   RefSeq; NP_001019497.1; NM_001024326.1.
DR   RefSeq; XP_008761042.1; XM_008762820.1.
DR   AlphaFoldDB; Q5M7U5; -.
DR   SMR; Q5M7U5; -.
DR   STRING; 10116.ENSRNOP00000012280; -.
DR   PaxDb; Q5M7U5; -.
DR   PRIDE; Q5M7U5; -.
DR   GeneID; 500088; -.
DR   KEGG; rno:500088; -.
DR   UCSC; RGD:1565263; rat.
DR   CTD; 401409; -.
DR   RGD; 1565263; Rab19.
DR   VEuPathDB; HostDB:ENSRNOG00000009030; -.
DR   eggNOG; KOG0084; Eukaryota.
DR   HOGENOM; CLU_041217_23_1_1; -.
DR   InParanoid; Q5M7U5; -.
DR   OMA; CVVQHFR; -.
DR   OrthoDB; 1149105at2759; -.
DR   PhylomeDB; Q5M7U5; -.
DR   TreeFam; TF300097; -.
DR   Reactome; R-RNO-8873719; RAB geranylgeranylation.
DR   PRO; PR:Q5M7U5; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000009030; Expressed in thymus and 13 other tissues.
DR   Genevisible; Q5M7U5; RN.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..217
FT                   /note="Ras-related protein Rab-19"
FT                   /id="PRO_0000244614"
FT   MOTIF           46..54
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         72..76
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         130..133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         217
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           215
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           217
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24446 MW;  F02E8B85ED390B61 CRC64;
     MQFSSAARTV DENVDYLFKV ILIGDSNVGK TCVVQHFKSG VYSESQQNTI GVDFTVRSLE
     IDGKKVKMQV WDTAGQERFR TITQSYYRSA HAAIIAYDLT RRSTFESVPH WIHEIEKYGA
     ANLVIMLIGN KSDLWEKRHV LFEDACTLAE KYGLLAVLET SAKESRNIDE VFVLMAKELI
     ARNSLHLYGE SAQQGLPQDS SPVLVAHVPS ERTHCTC