ID   RAB19_XENTR             Reviewed;         213 AA.
AC   Q28IZ3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Ras-related protein Rab-19;
GN   Name=rab19; ORFNames=TNeu042f01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; CR760145; CAJ82446.1; -; mRNA.
DR   RefSeq; NP_001017246.1; NM_001017246.2.
DR   RefSeq; XP_012814550.1; XM_012959096.2.
DR   AlphaFoldDB; Q28IZ3; -.
DR   SMR; Q28IZ3; -.
DR   STRING; 8364.ENSXETP00000016374; -.
DR   PaxDb; Q28IZ3; -.
DR   Ensembl; ENSXETT00000005753; ENSXETP00000005753; ENSXETG00000002673.
DR   GeneID; 550000; -.
DR   KEGG; xtr:550000; -.
DR   CTD; 401409; -.
DR   Xenbase; XB-GENE-495128; rab19.
DR   eggNOG; KOG0084; Eukaryota.
DR   HOGENOM; CLU_041217_23_1_1; -.
DR   InParanoid; Q28IZ3; -.
DR   OrthoDB; 1149105at2759; -.
DR   PhylomeDB; Q28IZ3; -.
DR   Reactome; R-XTR-8873719; RAB geranylgeranylation.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002673; Expressed in neurula embryo and 8 other tissues.
DR   ExpressionAtlas; Q28IZ3; baseline.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Ras-related protein Rab-19"
FT                   /id="PRO_0000366948"
FT   MOTIF           44..52
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         22..29
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         70..74
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         213
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           211
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           213
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   213 AA;  24145 MW;  0D84894EF9B008CB CRC64;
     MPGSNSLEDD PFDFLFKIIL IGDSNVGKTC VVHRFQSGVF AHNQQNTIGV DFTVRNMNIN
     GKKVKVQVWD TAGQERFRTI TQSYYRSAHG AIIAYDITRR QSFESVPHWI YEAEKYGAAN
     LMMMLIGNKS DLAEKRQILF EEACTLAEKH GLLAVLETSA KESHNVDEVF LLMAKELIAR
     NTFHYHSESP RNSFMLDSKP VLAPPEPDKN CLC