RAB1C_DICDI
ID RAB1C_DICDI Reviewed; 201 AA.
AC O76173; Q55DV4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ras-related protein Rab-1C;
GN Name=Rab1C; ORFNames=DDB_G0269174;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3-1;
RA Tanaka S., Morio T., Tanaka Y., Urushihara H., Ochiai H., Saito T.,
RA Yoshida M., Takeuchi I., Maeda M.;
RT "Role of human Rab1-homologue in Dictyostelium development.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- PTM: Although this sequence lacks the C-terminal cysteine motifs
CC subject to isoprenylation in other Rab proteins, it does have N-
CC terminal myristoylation and S-palmitoylation sequence motifs.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AB015237; BAA31150.1; -; mRNA.
DR EMBL; AAFI02000005; EAL71937.1; -; Genomic_DNA.
DR RefSeq; XP_646027.1; XM_640935.1.
DR AlphaFoldDB; O76173; -.
DR SMR; O76173; -.
DR STRING; 44689.DDB0191203; -.
DR PaxDb; O76173; -.
DR PRIDE; O76173; -.
DR EnsemblProtists; EAL71937; EAL71937; DDB_G0269174.
DR GeneID; 8616975; -.
DR KEGG; ddi:DDB_G0269174; -.
DR dictyBase; DDB_G0269174; rab1C.
DR eggNOG; KOG0084; Eukaryota.
DR HOGENOM; CLU_041217_23_1_1; -.
DR InParanoid; O76173; -.
DR OMA; FCIRTIE; -.
DR PhylomeDB; O76173; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-6811438; Intra-Golgi traffic.
DR Reactome; R-DDI-8854214; TBC/RABGAPs.
DR Reactome; R-DDI-8873719; RAB geranylgeranylation.
DR PRO; PR:O76173; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; HDA:dictyBase.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Lipoprotein; Myristate; Nucleotide-binding; Palmitate;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..201
FT /note="Ras-related protein Rab-1C"
FT /id="PRO_0000332748"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 62..70
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 40..48
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 58..65
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 88..92
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 146..149
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT BINDING 176..178
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62820"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 201 AA; 22343 MW; 881FC10CC7DCA4D4 CRC64;
MGCSPSKEGN GSFSSTSTSF IHGSESHPEY DMLLKILVIG DSGVGKSCML LRFADNRFTD
SYISTIGVDF CIRTIELDGK KIKLQIWDTA GQERFKTITT SYYRGAHGLI IVYDITSMDS
FNSIKRWLID VDRFASPSVL KLIVGNKCDL NSKRAVDFKI AKKFADELNI PIMETSAKES
TAIDEAFIKL ASDIKKSTPQ K
