ID   RAB21_GEOCY             Reviewed;         229 AA.
AC   Q8WQ53;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Ras-related protein Rab-21;
GN   Name=RAB21;
OS   Geodia cydonium (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Tetractinellida; Astrophorina; Geodiidae; Geodia.
OX   NCBI_TaxID=6047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gamulin V., Krasko A., Mueller W.E.G.;
RT   "Ras-related small GTPase Rab21 from the marine sponge Geodia cydonium.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Lipid-
CC       anchor {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; AJ315669; CAC85935.1; -; mRNA.
DR   AlphaFoldDB; Q8WQ53; -.
DR   SMR; Q8WQ53; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR   CDD; cd04123; Rab21; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041833; Rab21.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras-type.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW   Prenylation; Protein transport; Transport.
FT   CHAIN           1..229
FT                   /note="Ras-related protein Rab-21"
FT                   /id="PRO_0000121207"
FT   REGION          179..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           45..53
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        180..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         129..132
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           227
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           228
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  25345 MW;  C89BBB012D8C9F2A CRC64;
     MASPSDASRR RQATVKAKVV LLGEGAVGKT SLVLRYSENK FNDKHEQTLQ ASFVEKRLNI
     GGKRIQLAIW DTAGQERYHA LGPIYYRDSQ GAIIVYDITD EDSFHKARNW IKELKRMLGD
     KVTLCIVGNK IDLDRQRTVS EKDALEYAES VGAKHYYTSA KQSKGVAELF LDLAKRILEA
     NPPSSSTPPE SQRGAPSSHP PSQPRQRSTL IVTDDSEQPS PKQGGGCCS